AAA Biotech, LLC's Anti-NEURL1 Antibody, Rabbit Polyclonal is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Immunocytochemistry, Immunofluorescence, and Western Blot. The Anti-NEURL1 Antibody, Rabbit Polyclonal was generated using NEURL1 as the antigen and it reacts with Homo Sapiens, and Human.
Description
Drosophila Neur (dNeur) protein has two Neuralized Homology Repeat (NHR) domains and a C-terminal C3HC4 RING Zn-finger (RING) domain. In mammals, there are at least four proteins with NHR domains: NEURL1 (or NEURL, NEURL1A, NEUR1) and NEURL1B (or NEUR2) both have two NHR domains and a C-terminal RING domain, whereas NEURL2 (or Ozz-E3) and NEURL3 (or LINCR) have only one NHR domain and a C-terminal SOCS (suppressor of cytokines signalling) or RING domain, respectively. Mammalian NEURL1 and NEURL1B proteins interact with and ubiquitinate Notch ligands Delta-like1, Delta-like4 and Jagged1. Human Neuralized1 (NEURL1) was investigated as a potential tumor suppressor in medulloblastoma (MB). The gene is located at 10q25.1, a region demonstrating frequent loss of heterozygosity in tumors