The RBBP6 Antibody from AAA Biotech, LLC is a Rabbit Polyclonal antibody to RBBP6. This antibody recognizes Homo Sapiens, Human, and Mouse antigen. The RBBP6 Antibody has been shown to work in the following applications: EIA, Immunoassay, ELISA, Immunofluorescence, Immunohistochemistry, and Western Blot.
Description
E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome (PubMed: 18851979). May play a role as a scaffold protein to promote the assembly of the p53/TP53-MDM2 complex, resulting in increase of MDM2-mediated ubiquitination and degradation of p53/TP53; may function as negative regulator of p53/TP53, leading to both apoptosis and cell growth (By similarity). Regulates DNA-replication and the stability of chromosomal common fragile sites (CFSs) in a ZBTB38- and MCM10-dependent manner. Controls ZBTB38 protein stability and abundance via ubiquitination and proteasomal degradation, and ZBTB38 in turn negatively regulates the expression of MCM10 which plays an important role in DNA-replication (PubMed: 24726359)