Anti-RNH1 Antibody, Rabbit Polyclonal from AAA Biotech, LLC

Ribonuclease inhibitor (RNH1) is a cytosolic protein that binds with femtomolar affinity to human ribonuclease 1 (RNase 1) and homologous secretory ribonucleases. RNH1 contains 32 cysteine residues and has been implicated as an antioxidant. RNH1 is a leucine-rich repeat domains-containing protein that binds to and inhibits ribonucleases. RNH1 attenuates the activity of IRE1 by interacting with its ribonuclease domain. The Crithidia fasciculata RNH1 gene encodes an RNase H, an enzyme that specifically degrades the RNA strand of RNA-DNA hybrids. The RNH1 gene is contained within an open reading frame (ORF) predicted to encode a protein of 53.7 kDa. Major active forms of RNase H (38 and 45 kDa) were observed on activity gels of extracts of wild-type cells or cells in which one allele of RNH1 was disrupted. Both forms of the C.fasciculata RNase H are encoded by the RNH1 gene