ABCG2 (BXP-21) Antibody sc-58222 from Santa Cruz Biotechnology, Inc.

Product Specs
ItemABCG2 (BXP-21) Antibody
CompanySanta Cruz Biotechnology, Inc.
Price $316.00Supplier Page View Company Product Page
Catalog Numbersc-58222
NCBI Gene AliasesBCRP1, ABC15, MRX, Bcrp1, EST157481, GOUT1, MXR, CDw388, CDw338, CD338, BCRP, ABCP, UAQTL1, MXR1, MXR-1, BMDP
Antibody TypePrimary Antibodies
Quantity100 µg/ml
CloneBXP-21
ApplicationsWB, IP, IF, IHC(P)
Reactivitymouse, rat, human
FormatPurified
ClonalityMonoclonal
Conjugate/TagUnconjugated
Hostmouse
NCBI Full Gene NameATP binding cassette subfamily G member 2 (Junior blood group)
TargetABCG2
IsotypeIgG2a

Questions and Answers

What types of applications can I use this ABCG2 antibody for in my experiments?

The ABCG2 (BXP-21) antibody has been shown to work effectively in various applications, including Western Blotting, Immunofluorescence, Immunohistochemistry on paraffin-embedded sections, and Immunoprecipitation.

Is this antibody effective for studying multidrug resistance in cancer cells?

Yes, the ABCG2 antibody has been utilized in studies investigating multidrug resistance mechanisms in cancer cells. For instance, it was used to demonstrate that overexpression of ABCG2 contributes to the resistance of leukemia cells to cytotoxic agents, as reported in the literature.

Can this antibody be used to analyze the expression of ABCG2 in hypoxic conditions?

The ABCG2 antibody has been employed in research examining its expression under hypoxic conditions. One study indicated that hypoxia influences the levels of ABCG2, which is relevant for understanding its role in cancer stem cell populations and drug resistance.

What species does this antibody react with, and is it suitable for human studies?

The ABCG2 antibody is reactive with multiple species, including humans (Homo sapiens), mice (Mus musculus), and rats (Rattus norvegicus), making it suitable for studies involving human samples as well as animal models.

Santa Cruz Biotechnology, Inc.

10410 Finnell Street

Dallas, Texas 75220

United States

Phone: 1-800-457-3801
831-457-3801

Company Profile

Website: http://www.scbt.com/

(1) Protocol to differentially quantify spatially resolved viral protein-cellular protein interactions via proximity ligation assaysSTAR ProtocolsMarch 20, 2026Helene Hoenigsperger, Susanne Klute, Zoé Engels, Meta Volcic, Konstantin Maria Johannes SparrerRESOURCE,SOURCE,IDENTIFIER Antibodies,Antibodies,Antibodies ,, Monoclonal mouse anti-ABCG2 Antibody (BXP-21) (PLA 1:100),Santa Cruz Biotechnology,Cat#sc-58222; RRID: AB_630828 Monoclonal mouse anti-StrepII-tag Antibody (517) (PLA 1:400),Novus Biologicals,Cat#NBP2-43735 "Polyclonal

(2) Drug Interaction of Dasatinib with Thymoquinone: A Pharmacokinetic Study in RatsInternational Journal of Medical SciencesSeptember 3, 2025Ajaz Ahmad, Mohammad Raish, Khalid M. Alkharfy, Yousef A Bin Jardan, Abdul Ahad, Mohd Abul Kalam, Muzaffer Iqbal, Ibrahim A. Abdelrahman, Naushad Ali, Ali Akhtar, et al.grade) were procured from BDH Chemicals (Poole, UK). Anti- Pgp (sc-55510), CYP3A2 (sc-271033), BCPR (sc-58222) and β-actin (sc-47778) antibodies were obtained Santa Cruz Biotechology (Dallas, TX, USA). Animals

(3) Mutation T9I in Envelope confers autophagy resistance to SARS-CoV-2 OmicroniScienceJuly 18, 2025Susanne Klute, Rayhane Nchioua, Arne Cordsmeier, Jyoti Vishwakarma, Lennart Koepke, Hala Alshammary, Christoph Jung, Maximilian Hirschenberger, Helene Hoenigsperger, Jana-Romana Fischer, et al.AB_1850025 Monoclonal mouse anti-ABCG2 Antibody (BXP-21) (PLA 1:100),Santa Cruz Biotechnology,Cat#sc-58222; RRID: AB_630828 "Monoclonal mouse anti-β-actin Antibody (AC-15) (WB 1:10,000)",Sigma-Aldrich,Cat#A5441;

(4) Selective Inhibition of the ABCG2 Transporter by Primaquine Derivatives Reverses the Multidrug Resistance of Tumor CellsInt J Mol SciJune 3, 2025Marija Mioč, Maja Beus, Karla Carević, Zrinka Rajić, Balázs Sarkadi, Ágnes Telbisz, Marijeta Kraljthe primary antibody BXP-21 (1:100, IgG2a, Santa Cruz Biotechnology, Dallas, TX, USA, catalog number sc-58222). Slides were fixed with 4% paraformaldehyde (PFA) for 10 min and permeabilized with 0.1% saponin in

(5) Blood-brain barrier permeability increases with the differentiation of glioblastoma cells in vitroFluids and barriers of the CNSNovember 1, 2024Digiovanni S, Lorenzati M, Bianciotto OT, Godel M, Fontana S, Akman M, Costamagna C, Couraud PO, Buffo A, Kopecka J, et al.anti-Pgp/ABCB1 (clone C219, #MA1-26528, Invitrogen Life Technologies, 1/1000), anti-BCRP/ABCG2 (clone BXP-21, #sc-58222, Santa Cruz Biotechnology Inc., 1/250), anti-STAT3 (#06-596, Millipore; 1/1000), anti-phospho(Tyr705)STAT3

(6) Exploring bat-inspired cyclic tryptophan diketopiperazines as ABCB1 InhibitorsCommunications chemistryJuly 13, 2024Koh JYP, Itahana Y, Krah A, Mostafa H, Ong M, Iwamura S, Vincent DM, Radha Krishnan S, Ye W, Yim PWC, et al.Millipore), ABCB1 (GTX23364, GeneTex; sc-55510, Santa Cruz), ABCC1 (67228-1-Ig, Proteintech), ABCG2 (sc-58222, Santa Cruz), horseradish peroxidase (HRP)-conjugated secondary antibody (Jackson Immuno Research laboratories),

(7) High-throughput drug screening to investigate blood-brain barrier permeability in vitro with a focus on breast cancer chemotherapeutic agentsFrontiers in Drug DeliveryJune 27, 2024Carolin J. Curtaz, Sophia Wucherpfennig, Emad Al-Masnaea, Saskia-Laureen Herbert, Achim Wöckel, Patrick Meybohm, Malgorzata Burek(1:20000, Sigma- Aldrich, A3854), mouse-anti-BCRP monoclonal antibody (1:100, Santa Cruz Biotechnology, SC-58222), rabbit-anti-Cldn5 polyclonal antibody (1:500, Thermo Fisher Scientific, 34–1,600), rabbit-anti-Glut-1

(8) Herb-drug interaction: Effect of sinapic acid on the pharmacokinetics of dasatinib in ratsSaudi Pharmaceutical JournalNovember 1, 2023Mudassar Shahid, Ajaz Ahmad, Mohammad Raish, Yousef A Bin Jardan, Khalid M. Alkharfy, Abdul Ahad, Mohd Abul Kalam, Mushtaq Ahmad Ansari, Muzaffer Iqbal, Naushad Ali, et al.(Santa Cruz Biotechnology, Inc. Texas USA; sc-390883), Anti-BCRP/ABCG2 ((Santa Cruz Biotechnology, Inc. Texas USA; sc-58222) and anti-β-actin (Santa Cruz Biotechnology, Inc. Texas USA; LS-C147034). 2.2 Animals In vivo PK studies

(9) Establishment and Characterization of Multi-Drug Resistant p53-Negative Osteosarcoma SaOS-2 SublineDiagnostics (Basel, Switzerland)August 11, 2023Boichuk S, Bikinieva F, Valeeva E, Dunaev P, Vasileva M, Kopnin P, Mikheeva E, Ivoilova T, Mustafin I, Galembikova A.2735), (Cell Signaling Technology Inc., Danvers, MA, USA); anti-ABC subfamily G member 2 (cat. no. sc-58222), MDR-1 (cat. no. sc-55510), MRP-1 (cat. no. sc-18835), BRCA1 (cat. no. sc-642) (Santa Cruz Biotechnology,

(10) Unravelling the Therapeutic Potential of Antibiotics in Hypoxia in a Breast Cancer MCF-7 Cell Line ModelInternational Journal of Molecular SciencesJuly 16, 2023Almaz A. Akhunzianov, Alfiya I. Nesterova, Sjoerd Wanrooij, Yulia V. Filina, Albert A. Rizvanov, Regina R. Miftakhovawere incubated in a solution of primary antibodies, diluted with a ratio of 1:200: ABCG2 (cat. no. sc-58222; Santa Cruz Biotechnology, TX, USA), PCNA (cat. no. sc-7909; Santa Cruz Biotechnology, USA), and β-actin

(11) New findings on the action of hypericin in hypoxic cancer cells with a focus on the modulation of side population cellsBiomedicine & PharmacotherapyJuly 1, 2023Viktória Buľková, Jana Vargová, Marián Babinčák, Rastislav Jendželovský, Zbyněk Zdráhal, Pavel Roudnický, Ján Košuth, Peter FedoročkoBSA, membranes were incubated overnight at 4 ℃ with the following primary antibodies: BCRP (1:400; sc-58222; Santa Cruz Biotechnology, Dallas, TX, USA), HIF-1α (1:500; 610959; BD Biosciences), HIF-2α (1:1000;

(12) IFIT2 Depletion Promotes Cancer Stem Cell-like Phenotypes in Oral CancerBiomedicinesMarch 14, 2023Lai KC, Regmi P, Liu CJ, Lo JF, Lee TC.antibodies, anti-IFIT2 (sc-390724), anti-OCT3/4 (sc-5279), anti-NANOG (sc-293121), and anti-ABCG2 (sc-58222), were obtained from Santa Cruz Biotechnology (Santa Cruz, CA, USA); anti-TNFα (#6945) from Cell Signaling Technology

(13) Exostosin 1 Knockdown Induces Chemoresistance in MV3 Melanoma Cells by Upregulating JNK and MEK/ERK SignalingInternational journal of molecular sciencesMarch 13, 2023Pfeifer V, Weber H, Wang Y, Schlesinger M, Gorzelanny C, Bendas G.used to detect PAR-1 expression. For BCRP detection, we used ABCG2 antibody (Santa Cruz biotechnology; sc-58222; 1:200 dilution). As a secondary antibody, we used HRP-conjugated anti-mouse IgGκ binding protein (Santa Cruz biotechnology

(14) Nucleotide binding is the critical regulator of ABCG2 conformational transitionseLifeFebruary 10, 2023Gyöngy Z, Mocsár G, Hegedűs É, Stockner T, Ritter Z, Homolya L, Schamberger A, Orbán TI, Remenyik J, Szakacs G, et al.supernatant by affinity chromatography Antibody,BXP-21 (mouse monoclonal),Santa Cruz Biotechnology,Cat# sc-58222,(1:2500 dilution) Antibody,C-2 (mouse monoclonal),Santa Cruz Biotechnology,Cat# sc-8432,(1:2500 dilution) Antibody,Goat anti-mouse IgG-HRP

(15) Infigratinib (BGJ 398), a Pan-FGFR Inhibitor, Targets P-Glycoprotein and Increases Chemotherapeutic-Induced Mortality of Multidrug-Resistant Tumor CellsBiomedicinesMarch 3, 2022Boichuk S, Dunaev P, Mustafin I, Mani S, Syuzov K, Valeeva E, Bikinieva F, Galembikova A.4858T) (Cell Signaling Technology Inc., Danvers, MA, USA), anti-ABC subfamily G member 2 (cat. no. sc-58222), MDR-1 (cat. no. sc-55510), MRP-1 (cat. no. sc-18835) (Santa Cruz Biotechnology, Dallas, TX, USA),

(16) Bone Morphogenetic Protein 4 (BMP4) Enhances the Differentiation of Human Induced Pluripotent Stem Cells into Limbal Progenitor CellsCurrent Issues in Molecular BiologyNovember 29, 2021Hyun Soo Lee, Jeewon Mok, Choun-Ki JooPrimary/Secondary Antibody,Host,Dilution,Manufacturer mouse anti-ABCG2 (BXP21),Mouse,1:1000,Santa cruz (sc-58222) rabbit anti-ΔNp63 (4A4),Rabbit,1:1000,Santa cruz (sc-8431) goat-anti-cytokeratin 12,Goat,1:1000,Santa cruz

(17) sATP‑binding cassette subfamily G member 2 enhances the multidrug resistance properties of human nasal natural killer/T cell lymphoma side population cellsOncology reportsOctober 1, 2020Wu S, Zhang X, Dong M, Yang Z, Zhang M, Chen Q.(Sigma-Aldrich; Merck KGaA) for 1 h at RT. Cells were then incubated with the ABCG2 antibody (1:200; cat. no. sc-58222; Santa Cruz Biotechnology, Inc.) at 4°C overnight, following this, the slide was incubated with the

(18) Mesenchymal stem cells offer a drug-tolerant and immune-privileged niche to Mycobacterium tuberculosisNature communicationsJune 16, 2020Jain N, Kalam H, Singh L, Sharma V, Kedia S, Das P, Ahuja V, Kumar D.,Santa Cruz Biotechnology,,1:200,, 6,ABCC1,sc-18835,Santa Cruz Biotechnology,1:100,1:100,, 7,LAMP1,sc-20011,Santa Cruz Biotechnology,,1:200,, 8,ABCG2,sc-58222,Santa Cruz Biotechnology,1:100,1:100,, 9,Cathepsin D,ab19555,Abcam,,1:200,, 10,CD73-FITC (clone AD2),561254,BD Bioscience

(19) Characterization of ABC Transporters in EpiAirway™, a Cellular Model of Normal Human Bronchial EpitheliumInternational Journal of Molecular SciencesApril 30, 2020Bianca Maria Rotoli, Amelia Barilli, Rossana Visigalli, Francesca Ferrari, Caterina Frati, Costanza Annamaria Lagrasta, Maria Di Di Lascia, Benedetta Riccardi, Paola Puccini, Valeria Dall’Astaby Cell Signaling Technology (Euroclone, Pero, MI, Italy; 1:1000), anti-BCRP (ABCG2 (BXP-21); Cat# sc-58222) by Santa Cruz Biotechnology (DBA, Segrate, MI; Italy; 1:500) and α-tubulin (Anti-α-Tubulin, clone B-5-1-2;

(20) ABCG2 Overexpression Contributes to Pevonedistat ResistanceCancers (Basel)February 12, 2020Rishil J. Kathawala, Claudia M. Espitia, Trace M. Jones, Shariful Islam, Pranav Gupta, Yun-Kai Zhang, Zhe-Sheng Chen, Jennifer S. Carew, Steffan T. Nawrockicaspase-3 [9661] (Cell Signaling Technology, Danvers, MA, USA), anti-β-tubulin [T7816] (Sigma), anti-ABCG2 [sc-58222] (Santa Cruz Biotechnology, Santa Cruz, CA, USA), and sheep anti-mouse-horseradish peroxidase (HRP)

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ABCG2 (BXP-21) Antibody

ABCG2 (BXP-21) Antibody from Santa Cruz Biotechnology, Inc.

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Santa Cruz Biotechnology, Inc.

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ABCG2 (BXP-21) Antibody from Santa Cruz Biotechnology, Inc.

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