SREBP-1 (2A4) Antibody sc-13551 from Santa Cruz Biotechnology, Inc.

Product Specs
ItemSREBP-1 (2A4) Antibody
CompanySanta Cruz Biotechnology, Inc.
Price $316.00Supplier Page View Company Product Page
Catalog Numbersc-13551
Antibody TypePrimary Antibodies
NCBI Gene AliasesHMD, IFAP2, SREBP1, ADD1, bHLHd1
ApplicationsWB, IP, IF, IHC(P)
Quantity200 µg/ml
Reactivitymouse, rat, human, hamster
Clone2A4
ClonalityMonoclonal
Hostmouse
Conjugate/TagUnconjugated
FormatPurified
NCBI Full Gene Namesterol regulatory element binding transcription factor 1
TargetSREBP-1
IsotypeIgG1

Questions and Answers

What species does this SREBP-1 antibody work with in experiments?

The SREBP-1 (2A4) antibody has been shown to react with multiple species, including humans, mice, hamsters, and rats.

Can this antibody be used for immunofluorescence applications?

Yes, the SREBP-1 antibody has been utilized in immunofluorescence applications, as demonstrated in studies where it was used for co-staining with other markers to analyze lipid signatures in hepatocytes.

How has this antibody been applied in research related to liver diseases?

The SREBP-1 antibody has been referenced in studies investigating non-alcoholic fatty liver disease (NAFLD), where it was used to assess SREBP-1 expression levels in hepatocytes, revealing that SREBP-1 expression does not predict hepatic lipid accumulation.

What is the recommended dilution for using this antibody in Western blotting?

In Western blotting applications, the SREBP-1 antibody is typically used at a dilution of 1:50, as indicated in various studies that employed this antibody for protein detection.

Santa Cruz Biotechnology, Inc.

10410 Finnell Street

Dallas, Texas 75220

United States

Phone: 1-800-457-3801
831-457-3801

Company Profile

Website: http://www.scbt.com/

(1) Effects of α-Synuclein on the Lipid Phenotype of SZ95 Human Sebocytes: A Preliminary Study in the Context of Parkinson's DiseaseCellsAugust 21, 2026Sarah Mosca, Grazia Bottillo, Enrica Flori, Daniela Kovacs, Miriam Maiellaro, Francesca Lozzi, Alessia Cavallo, Christos C. Zouboulis, Giulia Simmini, Alessia Luppino, et al.(ab156947) and anti-FADS2 antibody (ab72189) were purchased from Abcam (Abcam, Cambridge, UK). Anti-SREBP1 (sc-13551) and anti-PPARγ (sc-7273) antibodies were purchased from Santa Cruz Biotechnology (1422 DR, Uithoorn,

(2) Brain corticogenesis promotes SARS-CoV-2 neuro-glial tropism through lipid-dependent viral replicationStem Cell ReportsAugust 11, 2026Byoung-San Moon, Dae-Gyun Ahn, Jieun Park, Nhu Thi Quynh Mai, Da-Jin Jeong, Hyowon Hong, Sae-Bom Yoon, Sunhee Lee, Gun Young Yoon, Chonsaeng Kim, et al.anti-GAPDH,Abcam,Cat#ab181602; RRID: AB_2630358 Mouse monoclonal anti-SREBP1,Santa Cruz Biotechnology,Cat#sc13551; RRID: AB_628282 Rabbit polyclonal anti-LDLR,Abcam,Cat#ab30532; RRID: AB_881272 Rabbit monoclonal

(3) Microenvironmental arginine restriction sensitizes pancreatic cancers to polyunsaturated fatty acids by suppression of lipid synthesisElifeAugust 5, 2026Patrick B Jonker, Mumina Sadullozoda, Guillaume Cognet, Juan J Apiz Saab, Kelly H Sokol, Violet X Wu, Deepa Kumari, Colin Sheehan, Mete E Ozgurses, Darby Agovino, et al.indicated. The following antibodies were used for immunoblot analysis: SREBP1 (Santa Cruz Biotechnology, sc-13551; 1:100 dilution), Beta-actin (Proteintech 660009-lg; 1:5000 dilution), p-S6 serine 235 (Cell Signaling Technology

(4) Hepatocyte-specific PPARγ Deletion Uncovers Role of an Antagonistic PPARγ–HNF4α Transcriptional Axis in Metabolic Dysfunction–Associated Steatotic Liver Disease ProgressionThe American Journal of PathologyAugust 1, 2026Shehnaz Bano, Matthew A. Copeland, Jia-Jun Liu, Anne Orr, John W. Stoops, Wendy M. Mars, Silvia Liu, Joseph Locker, George K. Michalopoulos, Bharat Bhushan(#2435S), SCD-1 (#2794S), and β-actin-HRP (#12262S) from Cell Signaling Technology; SREBP-1 (1:200; sc-13551), TGF-β1 (sc-146), and LPL (sc-373759) from Santa Cruz Biotechnology (Dallas, TX); HNF4α (1:1000; PP-H1415-00)

(5) Uremic toxins promote renal fatty acid synthesis and fibrosis via activating aryl hydrocarbon receptorNature CommunicationsJuly 10, 2026Hongyan Xie, Yitao Zhang, Li Lu, Hengjiang Guo, Xi’ang Sun, Ming Ning, Xin Xie, Luxin Li, Yangyang Niu, Jingyao Li, et al.anti-ubiquitin (Ub) antibody (10201-2-AP) were purchased from Proteintech (Wuhan, China); anti-SREBP1 antibody (sc-13551) and anti-Megalin antibody (sc-515772) were purchased from Santa Cruz (Dallas, Texas); anti-NCC antibody

(6) ZRSR1 protects against obesity-associated hepatic lipogenesis independent of minor intron splicingLife MetabJuly 8, 2026Yinkun Fu, Hongyong Song, Yinglin Han, Ding Chen, Wenyan Li, Ying Sun, Ming He, Xin Peng, Xu-Yun Zhaofollows: ZRSR1 was customized from PTMbio; ZRSR2 (Invitrogen, PA5-41797) was from Thermo Fisher; SREBP-1 (sc-13551) and LXR (sc-377260) were from Santa Cruz; HSP90 (13171-1-AP), HA (51064-2-AP), FLAG (20543-1-AP), LAMIN

(7) Korean red ginseng extract ameliorates high-fat diet-induced hyperlipidemia by modulating the gut microbiota-liver metabolic axisJournal of Ginseng ResearchJuly 1, 2026Yannan Zheng, Mingyue Lv, Hongxi Xu, Errui Zhang, Min Zheng, Trinh Thach Thi Nguyen, Shijie Wan, Man Yuan, Weiliang Guantibodies used for detection of PPARα (Santa Cruz, sc-398394, 1:1000 diluted), and SREBP-1c (Santa Cruz, sc-13551, 1:1000 diluted). 2.11 Statistical analysis Statistical analysis of all data was performed using GraphPad

(8) Zingiber officinale Leaf Subcritical Water Extract Suppresses Adipogenesis and Lipogenesis in 3T3-L1 Adipocytes via the AMPK-SREBP-1c Signaling PathwayInt J Med SciJune 4, 2026Eun-Min Jun, Jong-Yeon Kim, Jeong-Sook Choe, Eun-Jung Park, Hae-Jeung Lee,Cell Signaling Technology,2535S AMPK,Rabbit,Cell Signaling Technology,2532S SREBP-1c,Mouse,Santa Cruz,SC-13551 Phospho-p38,Rabbit,Cell Signaling Technology,4511S p38,Rabbit,Cell Signaling Technology,8690S Phospho-JNK,Rabbit,Cell Signaling Technology

(9) Microenvironmental arginine restriction sensitizes pancreatic cancers to polyunsaturated fatty acids by suppression of lipid synthesisbioRxivMay 4, 2026Patrick B. Jonker, Mumina Sadullozoda, Guillaume Cognet, Juan J. Apiz Saab, Kelly H. Sokol, Violet X. Wu, Deepa Kumari, Colin Sheehan, Mete E. Ozgurses, Darby Agovino, et al.indicated. The following antibodies were used for immunoblot analysis: SREBP1 (Santa Cruz Biotechnology, sc-13551; 1:100 dilution), Beta-actin (Proteintech 660009-lg; 1:5000 dilution). The following secondary antibodies

(10) Pirfenidone Suppresses Liver Fibrosis Through Inhibition of TGF-β-Associated Lipid Metabolic Remodeling in Hepatic Stellate CellsInt J Mol SciApril 30, 2026Yuelu Lan, Sijia Li, Shuangli Zhu, Can Pan, Kai Fu, Xueping Wang, Liwu Fu, Fang WangDanvers, MA, USA), anti-total p70 S6K (CST, Cat# 9202, Danvers, MA, USA), anti-SREBP1 (Santa Cruz, Cat# sc-13551, Dallas, TX, USA) and appropriate loading controls such as GAPDH (proteintech, Cat# 60004-1-Ig, Rosemont,

(11) Tissue-selective COPII modulator SEC16B aggravates cardiovascular disease by promoting lipid exportThe EMBO JournalApril 24, 2026Xiao Wang, Yating Hu, Lu Liu, Runze Huang, Yawei Wang, Bing Liu, Yifei Zhao, Yuangang Zhu, Jia Lv, Liang Liu, et al.15397-1-AP Rabbit anti-SEC31A,Proteintech,Cat# 17913-1-AP Mouse anti-SREBP1 (2A4),Santa Cruz Biotechnology,Cat# sc-13551 Rabbit anti-FASN,Proteintech,Cat# 10624-2-AP Rabbit anti-ACC,Abcam,Cat# ab45174 Mouse anti-HA,Proteintech,Cat#

(12) INSIG1/2 succination mediated by the moonlighting function of ADSL promotes lipogenesis and liver tumorigenesisNature CommunicationsMarch 15, 2026Yuran Duan, Shuo Wang, Jianyu Liu, Wenxing Qin, Yuli Shen, Yueru Hou, Xue Sun, Yanni Lin, Zhiqiang Hu, Bofei Dong, et al.normal rabbit IgG (sc-2027), mouse ADSL (sc-365623), PKCθ (sc-81534), ERK1/2 (sc-514302), SREBP-1 (sc-13551), His (sc-8036), GST (sc-138), and tubulin (sc-8035) antibodies were obtained from Santa Cruz Biotechnology.

(13) Tofogliflozin attenuates liver steatosis and fibrosis in non-diabetic non-alcoholic steatohepatitis miceBMC GastroenterologyJanuary 15, 2026Yoshinori Ozono, Hiroshi Kawakami, Hiroshi Hatada, Naomi Uchiyama, Souichiro Ogawa, Keisuke Uchida, Hotaka Tamura, Yuri Komaki, Kenichi Nakamura, Hisayoshi Iwakiri, et al.(FXR) (#72105, Cell Signaling Technology), and sterol regulatory element binding protein-1c (SREBP-1c) (sc-13551, Santa Cruz Biotechnology, TX, USA). The membranes were washed with TBST and incubated with goat anti-rabbit

(14) Deficiency of glycogen synthase promotes lipid accumulation through ChREBP and AKT-mTOR1-SREBP1 axis activation in miceJournal of Lipid ResearchJanuary 1, 2026Liangkui Li, Jianan Lang, Longyan Yang, Dong Zhaophospho-p70 S6 kinase (97596) were purchased from Cell Signaling Technology. Antibodies against SREBP1 (sc-13551), DGAT1 (sc-26173), and DGAT2 (sc-32400) were purchased from Santa Cruz Biotechnology. Antibodies against

(15) Emodin Enhances Rosiglitazone’s Therapeutic Profile by Dual Modulation of SREBP1-Mediated Adipogenesis and PPARγ-Driven ThermogenesisPharmaceuticals (Basel)November 27, 2025Meng Li, Yi-Rong Wang, Xue Wang, Xiao-Li Xiao, Yun-Hong Sun, Sheng-An Zhang, Yan-Qi Dang, Kai Wang, Wen-Jun Zhouhigh-grade ethanol and isopropanol were also sourced from Sigma-Aldrich. Antibodies against SREBP-1 (sc-13551), PPARγ (sc-7273), PGC-1α (sc-518025), and UCP1 (sc-293418) were from Santa Cruz Biotechnology (Dallas,

(16) Combination of THU/ALK-5i exhibits profound anti-MASH activity through suppression of lipogenesis and fibrogenesisScientific ReportsNovember 14, 2025Kampeebhorn Boonloh, Eun Soo Lee, Su Ho Jo, Na Won Park, So Bin Lee, Choon Hee Chungconnective tissue growth factor (CTGF; SC-101586), sterol regulatory element-binding protein-1c (Srebp-1c; #SC-13551), fatty acid synthase (Fasn; SC-55580), monocyte chemoattractant protein-1 (MCP-1; SC-28879), interleukin-1β

(17) The Functional Interaction Between PRDM16 and the SREBP Pathway Controls Lipid MetabolismInternational Journal of Molecular SciencesOctober 22, 2025Hafiz Majid Mahmood, Maria Teresa Bengoechea-Alonso, Dana E. Al-Ansari, Khaled Machaca, Johan EricssonCell Signaling Technology (Danvers, MA, USA). Antibodies against HMG-CoA synthase (sc-271543), SREBP1 (sc-8984 and sc-13551), GST (sc-138), Myc (sc-40), and HA (sc-805) were purchased from Santa Cruz Biotechnology (Dallas, TX,

(18) Chronic Waterborne Exposure to Polystyrene Microplastics Induces Kupffer Cell Polarization Imbalance and Hepatic Lipid AccumulationThe FASEB JournalSeptember 15, 2025Ting Li, Zhenghong Yao, Yuxin Huang, Ran Li, Lu Zhang, Rucheng Chen, Weijia Gu#29119‐1‐AP, Proteintech, USA), SREBP‐1 Antibody (2A4) (Sterol‐regulatory Element Binding Protein 1, sc‐13551, Santa Cruz, USA), CPT1α Polyclonal antibody (Carnitine Palmitoyltransferase 1α, #15184‐1‐AP, Proteintech,

(19) Chronic Waterborne Exposure to Polystyrene Microplastics Induces Kupffer Cell Polarization Imbalance and Hepatic Lipid AccumulationFASEB JSeptember 3, 2025Ting Li, Zhenghong Yao, Yuxin Huang, Ran Li, Lu Zhang, Rucheng Chen, Weijia Gu#29119‐1‐AP, Proteintech, USA), SREBP‐1 Antibody (2A4) (Sterol‐regulatory Element Binding Protein 1, sc‐13551, Santa Cruz, USA), CPT1α Polyclonal antibody (Carnitine Palmitoyltransferase 1α, #15184‐1‐AP, Proteintech,

(20) Inhibition of SREBP-1c rescues hepatic CYP7B1 expression and bile acid synthesis in malnourished miceAmerican Journal of Physiology-Gastrointestinal and Liver PhysiologyJuly 1, 2025Xiaoyang Wan, Krishnakant G. Soni, Jong Min Choi, Sun Yun Jung, Margaret E. Conner, Geoffrey A. Preidisand bovine serum albumin. The pre-cleared chromatin solution was incubated with 2.0 μg anti-SREBP-1 (#sc-13551, Santa Cruz), anti-SP1 (#21962–1-AP, Proteintech), or mouse IgG (#sc-2025, Santa Cruz) at 4° C overnight.

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7/20/2023Antibody From Santa Cruz Biotechnology Works Great for Detecting SREBP-1 YONG MTo test whether sulfated 25-OH cholesterol (25HC3S) treatment in human THP-1 cells, affects SREbinding protein 1 (SREBP1) expression. The results showed that 25HC3S decreased the SREBP1 mature form.

SREBP-1 (2A4) Antibody

SREBP-1 (2A4) Antibody from Santa Cruz Biotechnology, Inc.

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Santa Cruz Biotechnology, Inc.

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SREBP-1 (2A4) Antibody from Santa Cruz Biotechnology, Inc.

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