IRP-2 (7H6) Antibody sc-33682 from Santa Cruz Biotechnology, Inc.

Product Specs
ItemIRP-2 (7H6) Antibody
CompanySanta Cruz Biotechnology, Inc.
Price $316.00Supplier Page View Company Product Page
Catalog Numbersc-33682
Quantity200 µg/ml
ApplicationsWB, IP, IF, IHC(P), ELISA
Reactivityhuman
FormatPurified
Conjugate/TagUnconjugated
Antibody TypePrimary Antibodies
Clone7H6
Hostmouse
TargetIRP-2 (iron regulatory protein-2)
IsotypeIgG1
NCBI Gene AliasesIRP2AD, IRE-BP 2, NDCAMA, IRP2, ACO3, IRE-BP2
ClonalityMonoclonal
NCBI Full Gene Nameiron responsive element binding protein 2

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Santa Cruz Biotechnology, Inc.

10410 Finnell Street

Dallas, Texas 75220

United States

Phone: 1-800-457-3801
831-457-3801

Company Profile

Website: http://www.scbt.com/

(1) Biomembrane-coated Nanoparticles Targeting circHIF1α Suppress Ovarian Cancer Metastasis and Cisplatin Resistance by Mediating System Xc⁻ Inactivation via SLC7A11/SLC3A2 to Induce Ferroptosis in Cancer Stem CellsInt J Biol SciMay 18, 2026Yinyi Chang, Jingjing Wang, Liying Ma, Yi Liu, Yumeng Zhu, Yu Yi, Dongdong Zhang, Zitong Zhao, Li Sun, Yongmei Song(Cell Signaling Technology, USA, 4267S), anti-IRP1 (Santa Cruz, sc-166022), anti-IRP2 (Santa Cruz, sc-33682), and anti-NRF2 (Santa Cruz, sc-365949). Cell proliferation assay The proliferation of different cell

(2) Targeting iron regulatory protein 2 (IRP2) to disrupt iron metabolism enhances radiosensitivity through mitochondrial dysfunction in breast cancer cellsCell Death DiscoveryJuly 31, 2025Ye Yeong Jeong, Jieon Hwang, Areum Park, Sungmin Cho, Inyoung Cho, Soseul Won, You Me Shin, Sung Eun Kim, Chan Hoon Maeng, Jaemoon Yang, et al.phosphatase and protease inhibitors (GenDEPOT). The following primary antibodies were used: IRP-2 (7H6) (SC-33682, Santa Cruz, Dallas, Texas 75220 USA), CD71 (SC-32272, Santa Cruz), RAD51 (8875S, Cell Signaling, Danvers,

(3) IRP1 mediated ferroptosis reverses temozolomide resistance in glioblastoma via affecting LCN2/FPN1 signaling axis depended on NFKB2iScienceAugust 18, 2023Lan Y, Yang T, Yue Q, Wang Z, Zhong X, Luo X, Zuo B, Zhang M, Zeng T, Liu B, et al.RESOURCE,SOURCE,IDENTIFIER Antibodies,Antibodies,Antibodies ,, Rabbit anti-ACO1,Abcam,Cat# ab236773 Mouse anti-IRP2,Santa Cruz Biotechnology,Cat# sc33682; RRID: AB_2126703 Rabbit anti-LCN2,Proteintech,Cat# 26991-1-AP; RRID: AB_2880715 Rabbit anti-FPN1,Proteintech,Cat#

(4) LncRNA modulates Hippo-YAP signaling to reprogram iron metabolismNature communicationsApril 20, 2023He XY, Fan X, Qu L, Wang X, Jiang L, Sang LJ, Shi CY, Lin S, Yang JC, Yang ZZ, et al.(10084-2-AP, 1:1000 for IB), and anti-DMT1 (20507-1-AP, 1:1000 for IB) from Proteintech; anti-IRP2 (sc-33682, 1:1000 for IB) from Santa Cruz Biotechnology; anti-TFR1 (A5865, 1:1000 for IB), anti-FTH1 (A19544,

(5) Osteoporotic bone loss from excess iron accumulation is driven by NOX4-triggered ferroptosis in osteoblastsFree radical biology & medicineMarch 1, 2023Zhang H, Wang A, Li G, Zhai Q, Huang Z, Wang X, Cao Z, Liu L, Liu G, Chen B, et al.

(6) Optimization of Biotinylated RNA or DNA Pull-Down Assays for Detection of Binding Proteins: Examples of IRP1, IRP2, HuR, AUF1, and Nrf2International journal of molecular sciencesFebruary 10, 2023Tsuji Y.primary antibodies and conditions used in this study are as follows: Anti-IRP2 mouse monoclonal antibody (SC-33682, lot K0409, Santa Cruz Biotechnology, Dallas, TX, USA), 500~1000-fold dilution with 1% BSA in Tween/TBS,

(7) NCOA4 links iron bioavailability to DNA metabolismCell reportsAugust 16, 2022Federico G, Carrillo F, Dapporto F, Chiariello M, Santoro M, Bellelli R, Carlomagno F.

(8) KS10076, a chelator for redox-active metal ions, induces ROS-mediated STAT3 degradation in autophagic cell death and eliminates ALDH1(+) stem cellsCell reportsJuly 19, 2022Kim J, Park A, Hwang J, Zhao X, Kwak J, Kim HW, Ku M, Yang J, Kim TI, Jeong KS, et al.

(9) Iron-regulated assembly of the cytosolic iron-sulfur cluster biogenesis machineryThe Journal of biological chemistryJuly 1, 2022Fan X, Barshop WD, Vashisht AA, Pandey V, Leal S, Rayatpisheh S, Jami-Alahmadi Y, Sha J, Wohlschlegel JA.#F1804 and Proteintech), ISCU1/2 (Proteintech), HIF1α (Bethyl A300–286A), IRP2 (Santa Cruz Biotechnology sc-33682, Lot #B1116), FBXL5 (BioLegend Clone 3F5G12G9 or 10F4H9D12), GAPDH (Proteintech HRP-60004), and TUBA

(10) Dynamic O-GlcNAcylation coordinates ferritinophagy and mitophagy to activate ferroptosisCell discoveryMay 3, 2022Yu F, Zhang Q, Liu H, Liu J, Yang S, Luo X, Liu W, Zheng H, Liu Q, Cui Y, et al.NCOA4 (Abnova, h00008031-m05); LAMP1 (Developmental Studies Hybridoma Bank, H4A3); IRP2 (Santa Cruz, Sc-33682); TOM20 (BD, 612278); TIM23 (BD, 611223); TOM22 (Proteintech, 11278-1-ap); HSP60 (Cell Signaling, 12165s);

(11) Cyst(e)inase-Rapamycin Combination Induces Ferroptosis in Both In Vitro and In Vivo Models of Hereditary Leiomyomatosis and Renal Cell CancerMolecular cancer therapeuticsMarch 1, 2022Kerimoglu B, Lamb C, McPherson RD, Ergen E, Stone EM, Ooi A.were used: Actin (Sigma), FTH1 (Santa Cruz Biotechnology, SC-376594), IRP2 (Santa Cruz Biotechnolog, SC-33682), S6 (Cell Signaling Technology, 54D2), p-S6 (Cell Signaling Technology, 91B2), 2-SC (Discovery Antibodies,

(12) Esophageal Cancer Stem-like Cells Resist Ferroptosis-Induced Cell Death by Active Hsp27-GPX4 PathwayBiomoleculesDecember 29, 2021Liu CC, Li HH, Lin JH, Chiang MC, Hsu TW, Li AF, Yen DH, Hsu HS, Hung SC.tcua8598) were purchased from Taiclone; IRP1 (1:100; cat. no. sc-166022) and IRP2 (1:100; cat. no. sc-33682) were purchased from Santa Cruz. HSP27 (1:3000; cat. no. ARG65757) and Phospho-HSP27 (Ser78) (1:1000;

(13) Paralogous synthetic lethality underlies genetic dependencies of the cancer-mutated gene STAG2Life science allianceNovember 1, 2021Bailey ML, Tieu D, Habsid A, Tong AHY, Chan K, Moffat J, Hieter P.from Millipore, RAD21 (05-908); from Novus, CAS9 (NBP2-36440); from Santa Cruz, STAG2 (sc81852), IRP2 (sc33682), and TFRC (sc65582); from Sigma-Aldrich, FLAG M2 (F1804); rat-anti-tubulin was clone YOL1/34. Secondary

(14) Estrogen signaling differentially alters iron metabolism in monocytes in an Interleukin 6-dependent mannerImmunobiologySeptember 1, 2020Bajbouj K, Shafarin J, Muhammad JS, Ali A, Unnikannan H, Suleiman B, Al-Jabi N, Menon K, Hamad M.

(15) Exploiting the passenger ACO1-deficiency arising from 9p21 deletions to kill T-cell lymphoblastic neoplasia cellsCarcinogenesisAugust 12, 2020Gonzalez-Sanchez L, Cobos-Fernandez MA, Lopez-Nieva P, Villa-Morales M, Stamatakis K, Cuezva JM, Marin-Rubio JL, Vazquez-Dominguez I, Gonzalez-Vasconcellos I, Salido E, et al.

(16) FDXR regulates TP73 tumor suppressor via IRP2 to modulate aging and tumor suppressionThe Journal of pathologyJuly 1, 2020Zhang J, Kong X, Zhang Y, Sun W, Wang J, Chen M, Chen X.

(17) Dihydrolipoamide dehydrogenase regulates cystine deprivation-induced ferroptosis in head and neck cancerRedox biologyFebruary 1, 2020Shin D, Lee J, You JH, Kim D, Roh JL.Cell Signaling Technology), ACO1 (ab126595, Abcam), ACO2 (ab110321, Abcam), and iron regulatory protein (IRP) 2 (sc-33682, Santa Cruz Biotechnology, Inc., Dallas, TX, USA). β-actin (BS6007 M, BioWorld, Atlanta, GA, USA) served

(18) Inhibition of Glutaredoxin 5 predisposes Cisplatin-resistant Head and Neck Cancer Cells to FerroptosisTheranosticsJanuary 1, 2020Lee J, You JH, Shin D, Roh JL.(bs-13395R, Bioss, Melbourne, FL, USA), xCT (ab37185, Abcam, Cambridge, UK), Gpx4 (ab125066, Abcam), IRP 2 (sc-33682, Santa Cruz Biotechnology, Inc., Dallas, TX, USA), transferrin receptor protein (TfR) 1 (NB100-92243,

(19) An Oxygen-Dependent Interaction between FBXL5 and the CIA-Targeting Complex Regulates Iron HomeostasisMolecular cellJuly 25, 2019Mayank AK, Pandey V, Vashisht AA, Barshop WD, Rayatpisheh S, Sharma T, Haque T, Powers DN, Wohlschlegel JA.

(20) Hypoxia Rescues Frataxin Loss by Restoring Iron Sulfur Cluster BiogenesisCellMay 30, 2019Ast T, Meisel JD, Patra S, Wang H, Grange RMH, Kim SH, Calvo SE, Orefice LL, Nagashima F, Ichinose F, et al.(FECH),GTX113435,Genetex Frataxin,GTX54036,Genetex GLRX5,HPA063716,Atlas Antibodies HIF1a,A300–286A,Bethyl Laboratories HSCB,GTX116372,Genetex IRP2,sc-33682,Santa Cruz ISCU,sc-373694,Santa Cruz KEAP1,10503,Proteintech Lipoic acid,437695,Calbiochem LYRM4,ARP57407_P050,Aviva Systems Biology

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IRP-2 (7H6) Antibody

IRP-2 (7H6) Antibody from Santa Cruz Biotechnology, Inc.

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Santa Cruz Biotechnology, Inc.

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IRP-2 (7H6) Antibody from Santa Cruz Biotechnology, Inc.

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