SREBP-2 (1C6) Antibody sc-13552 from Santa Cruz Biotechnology, Inc.

Product Specs
ItemSREBP-2 (1C6) Antibody
CompanySanta Cruz Biotechnology, Inc.
Price $316.00Supplier Page View Company Product Page
Catalog Numbersc-13552
Antibody TypePrimary Antibodies
NCBI Gene AliasesbHLHd2, lop13, SREBP2gc, SREBP2, SREBP-2, nuc
Reactivitymouse, rat, human
Clone1C6
Quantity200 µg/ml
ApplicationsWB, IP, IF
Conjugate/TagUnconjugated
FormatPurified
Hostmouse
ClonalityMonoclonal
NCBI Full Gene Namesterol regulatory element binding transcription factor 2, sterol regulatory element binding factor 2
TargetSREBP-2
IsotypeIgG1

Questions and Answers

What applications has the SREBP-2 (1C6) antibody been used for in scientific research?

The SREBP-2 (1C6) antibody has been shown to work in applications such as Western blotting, immunofluorescence, and immunoprecipitation. For instance, it was utilized in Western blotting to assess SREBP-2 protein levels in various studies, including those investigating cholesterol metabolism and cancer cell behavior (, ).

Can this antibody be used to study the role of SREBP-2 in cholesterol metabolism?

Yes, the SREBP-2 (1C6) antibody is suitable for studying cholesterol metabolism. It has been referenced in research that links SREBP-2 to the regulation of cholesterol synthesis and its interaction with other proteins involved in lipid metabolism, such as in the context of ERG28's role in cholesterol biosynthesis ().

Is the SREBP-2 (1C6) antibody effective in human cell lines?

The SREBP-2 (1C6) antibody has been effectively used in human cell lines, as demonstrated in studies involving HepG2 cells, where it was employed to analyze the expression and activation of SREBP-2 in response to various treatments affecting lipid metabolism (, ).

What species does the SREBP-2 (1C6) antibody react with?

The SREBP-2 (1C6) antibody is reactive with multiple species, including humans, mice, and rats. This broad reactivity allows for its application in various experimental models across different research contexts ().

Santa Cruz Biotechnology, Inc.

10410 Finnell Street

Dallas, Texas 75220

United States

Phone: 1-800-457-3801
831-457-3801

Company Profile

Website: http://www.scbt.com/

(1) Functional Suppression of SCAP Triggers Endoplasmic Reticulum Stress‐Dependent Ferroptosis by Impairing Cholesterol Metabolism in Gastric CancerAdvanced ScienceJune 29, 2026Qianqian Xu, Guangzhao Pan, Lele Zhang, Xiangliu Chen, Kui Zhang, Yang Lu, Zibo Duan, Aiping Chen, Hailong Shen, Yuxi Zhang, et al.(1:1000; Abcam, ab125186), anti‐INSIG1 (1:500; Santa Cruz, sc‐390504), anti‐SREBP2 (1:500; Santa Cruz, sc‐13552), anti‐HMGCR (1:500; Santa Cruz, sc‐271595), anti‐GPX4 (1:1000; Cell Signaling Technology, 52455S),

(2) HDL-mimetic peptide treatment reverses APOE4-induced transcriptomic and lipidomic alterations in the brain of humanized APOE miceAlzheimers DementJune 23, 2026Allison Chang, Minwoo Kim, Matthew Glittenberg, Wenhui Qu, Danni Li, Ling LiSignaling, D8D4G), sterol regulatory element‐binding protein 2 (SREBP2; 1:1000; Santa Cruz Biotechnology, sc‐13552), low‐density lipoprotein receptor (LDLR) (1:1000; Abnova, PAB8804), ATP‐binding cassette transporter

(3) Investigating the role of neuroglobin in cholesterol metabolism: a spotlight on brain-derived cellsLipids in Health and DiseaseJune 4, 2026Sara Caputo, Martina Parente, Mayra Colardo, Marco Fiocchetti, Maria Marino, Marco Segatto, Valentina Pallottiniovernight at 4 °C with primary antibodies (1% bovine serum albumin in PBS) against SREBP2 (Santa Cruz, sc-13552, dilution 1:40) and LAMP2 (Santa Cruz, sc-18822, dilution 1:1,000). After being incubated, the cells

(4) SREBP2 promotes macrophage alternative activation and allergic airway inflammation independent of cholesterol biosynthesisCell Death & DiseaseJune 3, 2026Yinfang Wu, Kua Zheng, LingLing Dong, Shenwei Gao, Yanping Wu, Zhengyuan Liu, Jieyu Li, Haipin Chen, Qingyu Weng, Miao Li, et al.anti-RETNLA (ab39626) were from Abcam; anti-Lamin A/C (sc-20681), anti-β-Actin (sc-47778), and anti-SREBP2 (sc-13552) were from Santa Cruz Biotechnology; anti-CD206 (24595) and anti-SREBP2 (25940) were from Cell Signaling Technology

(5) Western Diet Downregulates Hepatic Bitter Taste Receptors: Potential Link to Altered Lipid MetabolismMol Nutr Food ResMay 15, 2026Ewelina Pych, Anders Gudiksen, Henriette Pilegaard, Martin Krøyer RasmussenOvernight incubation at 4°C with primary antibodies against TAS2R38 (HPA054366, Sigma) and SREBP2 (sc‐13552, Santa Cruz Biotechnology) diluted in TBS‐T was followed by incubation with horseradish peroxidase HRP‐conjugated

(6) IDH2 deficiency enhances ferroptosis-induced vascular inflammation and remodeling in diabetesScientific ReportsMay 14, 2026Giang-Huong Vu, Shuyu Piao, Minsoo Kim, Sohee Jeon, Byeong Hwa Jeon, Cuk-Seong Kimanti-IDH3A (ab228596) (Abcam, Cambridge, UK), anti-ACSL4 (sc-271800), anti-GAPDH (sc-32233), anti-SREBP2 (sc-13552) (Santa Cruz Biotechnology, Santa cruz, CA, USA), anti-β-actin (3700 S) (Cell Signaling Technology,

(7) Microglial cholesterol reprogramming drives cognitive impairment under hypobaric hypoxiaJournal of NeuroinflammationApril 23, 2026Sitong Cao, Wenyu Ni, Yujie Fang, Qianqian Luo, Li Zhu, Zhangji Dong, Xueting WangOsaisbiofarm), anti-GFAP (3670, Cell Signaling Technology), anti-P2RY12 (OB-PRT120, Osaisbiofarm), anti-SREBP2 (sc-13552, Santa Cruz), anti-TUJ1 (66375-1-lg, Proteintech), anti-NeuN (OB-PGP006-T, Osaisbiofarm), anti-PSD95

(8) SENP1 drives de novo cholesterogenesis via disrupting SUMOylation-mediated SREBP2-FBXW7 interactionCancer & MetabolismApril 21, 2026Chun Yang, Qingbo Wang, Bangmin Han, Xun Shangguanare as follows: SENP1 (Cell Signaling, #11929), HMGCR (Proteintech, 13,533–1-AP), SREBP2 (Santa cruz, sc-13552), SQLE (Santa Cruz, sc-271651), Ki-67 (Abcam, ab16667), Cleaved PARP-1 (Cell Signaling, #5625). Filipin

(9) Integrated serum metabolomics reveal molecular mechanism of Xietu Hemu prescription on metabolic dysfunction-associated steatotic liver disease-related obesityWJHDecember 27, 2025Zhe Cheng, Yi-Fan Lu, Yi-Xian He, Wei Wei, Yi-Xuan Xie, Tian-Su Lv, Yi Wei, Yan Lou, Jiang-Yi Yu, Xi-Qiao ZhouProteintech (Wuhan, China); anti-AMPK (ab32047) from Abcam (United States); and anti-SREBP1/2 (sc-365513/sc-13552; for cytoplasmic protein detection) from Santa Cruz (United States). Other primary antibodies included

(10) Reconstruction of the transcriptional regulatory networks in the kidney of desert-adapted speciesCommunications BiologyNovember 28, 2025Fernando Alvira-Iraizoz, Benjamin T. Gillard, Audrys G. Pauža, Panjiao Lin, Alex Paterson, Pamela A. Burger, Mahmoud Hag Ali, Nabil Amor, Abdulaziz N. Alagaili, Abdu Adem, et al.sc-365513, Lot L0420), anti-mouse SREBP-2 (diluted 1:50 in 1% BSA PBS-t; Santa Cruz Biotechnology, Inc., sc-13552, Lot J0820) and anti-mouse INSIG-1 (diluted 1:50 in 1% BSA PBS-t; Santa Cruz Biotechnology, Inc., sc-390504,

(11) Defective lipid droplet biogenesis exacerbates oleic acid-induced cellular homeostasis disruption and ferroptosis in mouse cardiac endothelial cellsCell Death DiscovAugust 9, 2025Yun-Ting Wang, Alexandra K. Moura, Rui Zuo, Zhengchao Wang, Kiana Roudbari, Jenny Z. Hu, Mi Wang, Pin-Lan Li, Yang Zhang, Xiang Liβ-actin (Cell Signaling Technology 3700S), SREBP1 (Abcam ab28481), SREBP2 (Santa Cruz Biotechnology sc-13552), CHOP (Cell Signaling Technologies 2895S), HIF1α (Cell Signaling Technology 36169S), IgG from mouse serum

(12) Effects of Cholesterol Metabolism on Corneal Endothelial Dysfunction in Patients With Type 1 DiabetesInvest Ophthalmol Vis SciAugust 5, 2025Zhichao Ren, Zongyi Li, Shengqian Dou, Hongran Zhao, Lixin Xie(1/5000),14418-1-AP,Proteintech,USA AQP1,WB (1:1000),AF5231,Affinity,USA SREBF2,WB (1:1000)/IF (1:200),sc-13552,Santa Cruz,USA INSIG2,WB (1:1000),24766-1-AP,Proteintech,USA SQLE,WB (1:1000)/IF (1:200),12544-1-AP,Proteintech,USA LDLR,WB

(13) High-fat diet promotes lipotoxicity in the podocytes of uninephrectomized mice: a targeted lipidomics and kidney podocyte-specific analysisCell Death DiscovApril 23, 2025Se-Hyun Oh, You-Jin Kim, Subin Bae, Hee-Yeon Jung, So-Young Park, Jeong-Hoon Lim, Jang-Hee Cho, Chan-Duck Kim, Sun-Hee Park, Tae-Hwan Kwon, et al.1,SREBP1,Mouse,1:500,SC-365513,Santa Cruz Biotechnology Sterol regulatory element binding transcription factor 2,SREBP2,Mouse,1:500,SC-13552,Santa Cruz Biotechnology Acetyl-CoA carboxylase,ACC,Rabbit,1:1000,3676S,Cell Signaling Technology Phospho-acetyl-CoA

(14) Cth/Mpst double ablation results in early onset fatty liver disease in lean miceRedox BiolApril 15, 2025Antonia Katsouda, Maria Markou, Dimitrios Valakos, Ioannis Theodorou, Andreas Papapetropoulosanti-SQRDL (17256-1-AP, Proteintech), anti-SREBP1 (sc-365514, Santa Cruz Biotechnology) and anti-SREBP2 (sc-13552, Santa Cruz Biotechnology). Immunoblots were next processed with anti-rabbit (AP132P, Merck) or anti-mouse

(15) Regulation of CNS Lipids by Protease Activated Receptor 1Journal of NeurochemistryMarch 24, 2025Hyesook Yoon, Erin M. Triplet, Lincoln Wurtz, Whitney L. Simon, Chan‐Il Choi, Isobel A. ScarisbrickAB_10807410 (1:200) SREBP1,Santa Cruz,"sc-13551; AB_628282 (IF; 1:500, WB; 1:500)" SREBP2,Santa Cruz,"sc-13552; AB_2194250 (IF; 1:500, WB; 1:500)" Fa2h,Proteintech,15452-1-AP; AB_2101886 (WB; 1:1000) Ugt8,Proteintech,17982-1-AP;

(16) Cholesterol restriction primes antiviral innate immunity via SREBP1-driven noncanonical type I IFNsEMBO ReportsDecember 12, 2024Tasuku Nishimura, Takahisa Kouwaki, Ken Takashima, Akie Ochi, Yohana S Mtali, Hiroyuki Oshiumi(2A4),BD Biosciences,Cat# 557036; RRID: AB_396559 SREBP-2 antibody(1C6),SANTA CRUZ BIOTECHNOLOGY,Cat# sc-13552; RRID: AB_2194250 IFN omega antibody,Invitrogen,Cat# PA5-99819; RRID: AB_2818752 "Anti-Mouse IgG,

(17) Exosomes Derived from Adipose Mesenhymal Stem Cells Ameliorate Lipid Metabolism Disturbances Following Liver Ischemia-Reperfusion Injury in Miniature SwineInternational Journal of Molecular SciencesDecember 5, 2024Xiangyu Lu, Yue Wang, Chenxi Piao, Pujun Li, Lei Cao, Tao Liu, Yajun Ma, Hongbin WangChina), SCD1 (1:1000, Bioss, bs-3787R), ACOX1 (1:1000, Bioss, bs-5021R), SREBP-2 (1:500, Santa Cruz, sc-13552, Santa Cruz, CA, USA), ACC1 (1:1000, ABclonal, A19267), PPAR-α (1:1000, Bioss, bs-3614R), CPT1A (1:1000,

(18) Cholesterol-rich lysosomes induced by respiratory syncytial virus promote viral replication by blocking autophagy fluxNature CommunicationsJuly 26, 2024Lifeng Chen, Jingjing Zhang, Weibin Xu, Jiayi Chen, Yujun Tang, Si Xiong, Yaolan Li, Hong Zhang, Manmei Li, Zhong LiuLOT: 38) were obtained from Cell Signaling Technology (Danvers, MA, USA). Anti-SREBP2 antibody (Cat# sc-13552; WB, 1:1000; IF, 1:50; LOT: GR3376305-1) was acquired from Santa Cruz Biotechnology (Dallas, TX, USA).

(19) Olanzapine, risperidone and ziprasidone differently affect lysosomal function and autophagy, reflecting their different metabolic risk in patientsTranslational PsychiatryJanuary 8, 2024Marco Pozzi, Chiara Vantaggiato, Francesca Brivio, Genny Orso, Maria Teresa BassiAnti SREBP1 (ab3259), and LAMP1 (ab24170) antibodies were purchased from Abcam, Cambridge, UK. Anti SREBP2 (sc13552) and β-actin (sc47778) were purchased from Santa Cruz Biotechnology. Anti ACC1 (4190), phospho-ACC1

(20) Cholesterol-dependent homeostatic regulation of very long chain sphingolipid synthesisThe Journal of cell biologyDecember 4, 2023Kim Y, Mavodza G, Senkal CE, Burd CG.anti-β-actin (1:1,000, 3700S; CST); anti-HMGCR (1:1,000, NBP2-61616; Novus Biologicals); anti-SREBP2 (1:1,000, sc-13552; Santa Cruz); anti-CerS2 (1:1,000, HPA027262; Sigma-Aldrich); anti-CERT (1:1,000, HPA035645; Sigma-Aldrich);

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SREBP-2 (1C6) Antibody

SREBP-2 (1C6) Antibody from Santa Cruz Biotechnology, Inc.

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Santa Cruz Biotechnology, Inc.

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SREBP-2 (1C6) Antibody from Santa Cruz Biotechnology, Inc.

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