EPAS-1 (A-5) Antibody sc-46691 from Santa Cruz Biotechnology, Inc.

Product Specs
ItemEPAS-1 (A-5) Antibody
CompanySanta Cruz Biotechnology, Inc.
Price $316.00Supplier Page View Company Product Page
Catalog Numbersc-46691
NCBI Gene AliasesECYT4, HIF2A, HLF, MOP2, PASD2, bHLHe73
Antibody TypePrimary Antibodies
Quantity200 µg/ml
CloneA-5
ApplicationsWB, IP, IF, ELISA
Reactivityhuman
ClonalityMonoclonal
FormatPurified
Conjugate/TagUnconjugated
Hostmouse
NCBI Full Gene Nameendothelial PAS domain protein 1
TargetEPAS-1
IsotypeIgG2b

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Santa Cruz Biotechnology, Inc.

10410 Finnell Street

Dallas, Texas 75220

United States

Phone: 1-800-457-3801
831-457-3801

Company Profile

Website: http://www.scbt.com/

(1) HIF-2–Dependent Regulation of PTHrP and Paraneoplastic Hypercalcemia in Aggressive Clear-Cell Renal Cell CarcinomaCancer DiscoveryDecember 2, 2025Arijit Mal, Bingqing Xie, Zane Gray, Charlotte Small, Susmita G. Ramanand, Yunpeng Gao, Vanina Toffessi Toffessi Tcheuyap, Sashi Debnath, Alana Christie, Jeffrey Miyata, et al.in a semi-quantitative manner. Immunohistochemistry Immunohistochemistry (IHC) for HIF-2α (1:200, sc-46691, Santa Cruz) (RRID:AB_627523) was performed on TGs using a Dako Autostainer Link 48 as previously described

(2) Endogenous Targeting of Lipid Nanoparticles to Kidney TumorsACS NanoSeptember 2, 2025Amogh Vaidya, Yun-Chieh Sung, Vanina Toffessi Toffessi Tcheuyap, Chengcheng Zhang, Ramesh Butti, Arijit Mal, Sean Dilliard, Jing Liu, Eunice Song, Erick Guerrero, et al.were incubated overnight at 4 °C with a mouse monoclonal HIF2α antibody (Santa Cruz Biotechnology, SC46691, 1:50). After washing with PBS, sections were incubated with the Alexa Fluor 488-conjugated antimouse

(3) Hypoxic HPV-Positive Cancer Cells Are Particularly Sensitive to the Pro-Senescent Effects of B-MYB Repression Due to the Lack of Compensatory A-MYB InductionJ Med VirolMay 30, 2025Milica Velimirović, Alicia Avenhaus, Claudia Lohrey, Julia Bulkescher, Felix Hoppe-Seyler, Karin Hoppe-Seylersc‐398543), anti‐glyceraldehyde 3‐phosphate dehydrogenase (GAPDH) (FL‐335, sc‐25778), anti‐HIF‐2α (sc‐46691), anti‐PLK1 (F‐8, sc‐17783), anti‐Vinculin (7F9, sc‐73614), all from Santa Cruz Biotechnology; anti‐cleaved

(4) Hypoxia induces ROS-resistant memory upon reoxygenation in vivo promoting metastasis in part via MUC1-CNature CommunicationsSeptember 28, 2024Inês Godet, Harsh H. Oza, Yi Shi, Natalie S. Joe, Alyssa G. Weinstein, Jeanette Johnson, Michael Considine, Swathi Talluri, Jingyuan Zhang, Reid Xu, et al.and incubated overnight with primary antibodies against HIF-1α (#610958, BD Biosciences), HIF-2α (#sc-46691, Santa Cruz), p-NF-kBp65 (#3033, Cell Signaling), NF-kBp65 (#8242, Cell Signaling or # A2547, Abclonal),

(5) LncRNA ZFAS1 promotes invasion of medullary thyroid carcinoma by enhancing EPAS1 expression via miR-214-3p/UCHL1 axisJournal of cell communication and signalingJune 1, 2024Chen W, Wang S, Wei D, Zhai L, Liu L, Pan C, Han Z, Liu H, Zhong W, Jiang X.was analyzed using Image J software. The primary antibodies employed in this study were anti‐EPAS1 (sc‐46691, Santa Cruz) and anti‐UCHL1 (PA5‐29012, Invitrogen). β‐actin was used as the internal control for normalizing

(6) Clinicopathologic significance of the delta-like ligand 4, vascular endothelial growth factor, and hypoxia-inducible factor-2α in gallbladder cancerJournal of pathology and translational medicineMarch 1, 2023Park S, Kim J, Jang W, Kim KM, Jang KT.antibody (HPA023392, 1:50, Sigma-Aldrich, St. Louis, MO, USA) for 60 minutes in 37°C and with EPAS-1 (sc-46691, 1:50, Santa Cruz Biotechnology, Santa Cruz, CA, USA) for HIF2α detection for 120 minutes in 37°C, respectively.

(7) Mebendazole Treatment Disrupts the Transcriptional Activity of Hypoxia-Inducible Factors 1 and 2 in Breast Cancer CellsCancersFebruary 20, 2023Joe NS, Wang Y, Oza HH, Godet I, Milki N, Riggins GJ, Gilkes DM.incubated overnight in primary antibodies (HIF-1α (610959, BD Biosciences, San Jose, CA, USA), HIF-2α (SC-46691, Santa Cruz Biotechnology, Dallas, TX, USA), HIF-1β/ARNT (D28F3, Cell Signaling Technology, Danvers,

(8) HIF2 Inactivation and Tumor Suppression with a Tumor-Directed RNA-Silencing Drug in Mice and HumansClinical Cancer ResearchDecember 15, 2022Yuanqing Ma, Allison Joyce, Olivia Brandenburg, Faeze Saatchi, Christina Stevens, Vanina Toffessi Toffessi Tcheuyap, Alana Christie, Quyen N. Do, Oluwatomilade Fatunde, Alyssa Macchiaroli, et al.previously [26]. Tissues were stained with HIF2α antibodies (1:1800, clone A3, Bethyl Laboratories or 1:75, sc-46691, Santa Cruz) using citrate buffer antigen retrieval (K800521, Dako). Appropriate positive and negative

(9) FAM57A (Family with Sequence Similarity 57 Member A) Is a Cell-Density-Regulated Protein and Promotes the Proliferation and Migration of Cervical Cancer CellsCellsOctober 21, 2022Yang D, Strobel TD, Bulkescher J, Tessmer C, Hofmann I, Hoppe-Seyler F, Hoppe-Seyler K.were used: anti-β-Actin (sc-47778), anti-GAPDH (sc-25778), anti-Vinculin (sc-73614) and anti-HIF-2α (sc-46691) from Santa Cruz Biotechnology (Dallas, TX, USA), anti-phospho-AKT (S473) (#4058), anti-phospho-AKT

(10) Attenuating hypoxia driven malignant behavior in glioblastoma with a novel hypoxia-inducible factor 2 alpha inhibitorScientific reportsSeptember 16, 2020Renfrow JJ, Soike MH, West JL, Ramkissoon SH, Metheny-Barlow L, Mott RT, Kittel CA, D'Agostino RB Jr, Tatter SB, Laxton AW, et al.

(11) HIF-2 Complex Dissociation, Target Inhibition, and Acquired Resistance with PT2385, a First-in-Class HIF-2 Inhibitor, in Patients with Clear Cell Renal Cell CarcinomaClinical cancer research : an official journal of the American Association for Cancer ResearchFebruary 15, 2020Courtney KD, Ma Y, Diaz de Leon A, Christie A, Xie Z, Woolford L, Singla N, Joyce A, Hill H, Madhuranthakam AJ, et al.

(12) Repurposing propranolol as an antitumor agent in von Hippel-Lindau diseaseJournal of neurosurgeryOctober 1, 2018Shepard MJ, Bugarini A, Edwards NA, Lu J, Zhang Q, Wu T, Zhuang Z, Chittiboina P.After blocking, the membranes were probed with anti-VEGF (Thermo Fisher Scientific) or anti-HIF2α (sc-46691, Santa Cruz), and the immunoreactive signal was detected with the ChemiDoc MP Imaging System (Bio-Rad).

(13) Hypoxia induces copper stable isotope fractionation in hepatocellular carcinoma, in a HIF-independent mannerMetallomics : integrated biometal scienceNovember 9, 2016Bondanese VP, Lamboux A, Simon M, Lafont JE, Albalat E, Pichat S, Vanacker JM, Telouk P, Balter V, Oger P, et al.

(14) Targeting renal cell carcinoma with a HIF-2 antagonistNatureNovember 3, 2016Chen W, Hill H, Christie A, Kim MS, Holloman E, Pavia-Jimenez A, Homayoun F, Ma Y, Patel N, Yell P, et al.and incubated for 40 min at RT. Primary antibodies: HIF-1α (1:500, NB100-105, Novus), HIF-2α (1:200, sc-46691, Santa Cruz), Ki67 (ready-to-use, IR-626, Dako) and CD31 (1:200, LS-B1932, LifeSpan BioSciences). After

(15) A Small-Molecule Antagonist of HIF2α Is Efficacious in Preclinical Models of Renal Cell CarcinomaCancer researchSeptember 15, 2016Wallace EM, Rizzi JP, Han G, Wehn PM, Cao Z, Du X, Cheng T, Czerwinski RM, Dixon DD, Goggin BS, et al.

(16) Tuning Cell Differentiation into a 3D Scaffold Presenting a Pore Shape Gradient for Osteochondral RegenerationAdvanced healthcare materialsJuly 1, 2016Di Luca A, Lorenzo-Moldero I, Mota C, Lepedda A, Auhl D, Van Blitterswijk C, Moroni L.overnight at 4 °C with HIF-1α (28b) antibody (#sc-13515, Santa Cruz Biotechnology), or HIF-2α antibody (#sc-46691, Santa Cruz Biotechnology), diluted 1:250 in Tris-buffered saline containing 0.1% Tween-20. GAPDH antibody (#sc-365062,

(17) Influencing chondrogenic differentiation of human mesenchymal stromal cells in scaffolds displaying a structural gradient in pore sizeActa biomaterialiaMay 1, 2016Di Luca A, Szlazak K, Lorenzo-Moldero I, Ghebes CA, Lepedda A, Swieszkowski W, Van Blitterswijk C, Moroni L.overnight at 4 °C with HIF-1a (28b) antibody (#sc-13515, Santa Cruz Biotechnology), or HIF-2a antibody (#sc-46691, Santa Cruz Biotechnology), diluted 1:250 in Tris-buffered saline containing 0.1% Tween-20). GAPDH antibody

(18) Cezanne regulates E2F1-dependent HIF2α expressionJournal of cell scienceAugust 15, 2015Moniz S, Bandarra D, Biddlestone J, Campbell KJ, Komander D, Bremm A, Rocha S.

(19) New inhibitors of angiogenesis with antitumor activity in vivoJournal of medicinal chemistryMay 14, 2015Marín-Ramos NI, Alonso D, Ortega-Gutiérrez S, Ortega-Nogales FJ, Balabasquer M, Vázquez-Villa H, Andradas C, Blasco-Benito S, Pérez-Gómez E, Canales Á, et al.

(20) TLX activates MMP-2, promotes self-renewal of tumor spheres in neuroblastoma and correlates with poor patient survivalCell death & diseaseOctober 30, 2014Chavali PL, Saini RK, Zhai Q, Vizlin-Hodzic D, Venkatabalasubramanian S, Hayashi A, Johansson E, Zeng ZJ, Mohlin S, Påhlman S, et al.

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EPAS-1 (A-5) Antibody

EPAS-1 (A-5) Antibody from Santa Cruz Biotechnology, Inc.

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Santa Cruz Biotechnology, Inc.

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EPAS-1 (A-5) Antibody from Santa Cruz Biotechnology, Inc.

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