GATA-3 (HG3-31) Antibody sc-268 from Santa Cruz Biotechnology, Inc.

Product Specs
ItemGATA-3 (HG3-31) Antibody
CompanySanta Cruz Biotechnology, Inc.
Price $316.00Supplier Page View Company Product Page
Catalog Numbersc-268
NCBI Gene Aliasesjal, Gata-3, HDR, HDRS
Antibody TypePrimary Antibodies
CloneHG3-31
Reactivitymouse, rat, human, avian
Quantity200 µg/ml
ApplicationsWB, IP, IF, IHC(P)
Hostmouse
FormatPurified
Conjugate/TagUnconjugated
ClonalityMonoclonal
NCBI Full Gene NameGATA binding protein 3
TargetGATA-3
IsotypeIgG1

Questions and Answers

Can this antibody be used for studying GATA3 in breast cancer research?

Yes, the GATA-3 (HG3-31) antibody has been utilized in various studies related to breast cancer. For instance, it was employed in immunohistochemistry to confirm the expression of GATA3 in breast cell lines, aiding in the identification of potential new basal markers in breast cancer ().

What applications is this antibody suitable for in my experiments?

The GATA-3 antibody is suitable for several applications, including Western blotting, immunofluorescence, immunohistochemistry, and immunoprecipitation. It has been effectively used in these contexts to analyze GATA3 expression and its role in cellular processes (, ).

Is this antibody effective in detecting GATA3 in different species?

Yes, the GATA-3 antibody has been shown to react with multiple species, including humans, mice, rats, and chickens. This broad reactivity makes it a versatile tool for comparative studies across different model organisms ().

How has this antibody contributed to understanding GATA3's role in breast cancer?

Research has demonstrated that GATA3 functions as a tumor suppressor in breast cancer, and its expression is regulated by various factors, including progestins. The GATA-3 antibody has been crucial in studies that explore these regulatory mechanisms and their implications for tumor growth and differentiation ().

Santa Cruz Biotechnology, Inc.

10410 Finnell Street

Dallas, Texas 75220

United States

Phone: 1-800-457-3801
831-457-3801

Company Profile

Website: http://www.scbt.com/

(1) EZH2 directs HER2+ breast cancer progression through the modulation of epithelial plasticityEMBO ReportsJanuary 28, 2026Linshan Liu, Ellie J Massey, Dongmei Zuo, Alain Pacis, Mert Demirdizen, Elizabeth Podleszanski, Jessica Cinkornpumin, Yu Gu, Hailey Proud, Virginie Sanguin-Gendreau, et al.anti-Ezh1,Invitrogen,PA5-115205 Rabbit anti-p63,Abcam,ab124762 Rabbit anti-CK5,BioLegend,905504 Mouse anti-Gata3,Santa Cruz,sc-268 Rabbit anti-Foxa1,Abcam,ab173287 Mouse anti-E-cadherin,BD Biosciences,610182 Mouse anti-CK8,BioLegend,904804 Rabbit

(2) Cerium dioxide nanoparticles coated with benzo[a]pyrene modify aryl hydrocarbon receptor activity, trophoblast differentiation and mitochondrial network phenotype in human placentaPart Fibre ToxicolOctober 14, 2025Séverine A. Degrelle, Gaëlle Deval, Arnaud Tête, Claire Mikolajczak, Frank Giton, Marie-Léone Vignaud, Sonja Boland, Céline J. Guigon, Xavier Coumoul, Amal Zerrad-Saadi, et al.permeabilized in 0.5% Triton X-100 in PBS for 30 min, and then incubated for 1 h at 37 °C with 2 µg/mL GATA3 (#sc-268, Santa Cruz) and 2 µg/mL β-catenin (CTNNB #51,067–2-AP, Proteintech) or 1 µg/mL desmoplakin (DSP, (#ab71690,

(3) The citrullinating enzyme PADI4 governs progenitor cell proliferation and translation in developing hair folliclesScience AdvancesSeptember 12, 2025Kim Vikhe Patil, Nil Campamà Sanz, Kylie Hin-Man Mak, Wei Yang, Karl Annusver, Jasson Makkar, David Grommisch, Li Lei, Priyanka Sharma, Ryan R. Driskell, et al.1:500), LEF1 (Cell Signaling Technology, 2230T; clone C12A5; 1:1000), GATA3 (Santa Cruz Biotechnology, sc-268 1:100), GATA3 (Abcam, ab110093; KT77; 1:500), KI67 (Abcam, ab15580; 1:500), AE13 (Abcam, ab16113; 1:300),

(4) HER2; p53 Co-mutated Cancers Show Increased Histone Acetylation and are Sensitive to Neratinib plus Trastuzumab DeruxtecanbioRxivJuly 10, 2025Xiaoqing Cheng, Jacob Hsia, Jesus Iraheta, Joanna Gongora, Maureen Highkin, Xiaohua Jin, Zhanfang Guo, Julie L. Prior, John R. Edwards, Shunqiang Li, et al.ER𝞪 Antibody (D-12) (Santa Cruz Biotechnology, SC-8005), GATA-3 Antibody (Santa Cruz Biotechnology, SC-268), Secondary antibodies used include anti-rabbit IgG (H+L) Alexa Fluor 555 (Invitrogen, A-31572), anti-goat

(5) Mitochondrial morphology and energy metabolism in reprogrammed porcine expanded potential stem cellsAnimal BioscienceMarch 1, 2025Yun Ju Lee, Jae Hoon Song, Je Woo Lee, Tae Kyung Hong, Sang Jun Uhm, Kwonho Hong, Jeong Tae Do,R&D systems,AF1924 Primary,GATA4,Rabbit,Abcam,Ab84593 Primary,CDX2,Rabbit,Abcam,Ab76541 Primary,EOMES,Rabbit,Abcam,Ab23345 Primary,GATA3,Mouse,Santa Cruz,Sc-268 Secondary,Mouse IgG,Goat,Invitrogen,Alexa 488,A-11001 Secondary,Rabbit IgG,Goat,Invitrogen,Alexa 488,A-11008 Secondary,Goat

(6) Single-nucleus chromatin accessibility and transcriptomic map of breast tissues of women of diverse genetic ancestryNature MedicineDecember 1, 2024Poornima Bhat-Nakshatri, Hongyu Gao, Aditi S. Khatpe, Adedeji K. Adebayo, Patrick C. McGuire, Cihat Erdogan, Duojiao Chen, Guanglong Jiang, Felicia New, Rana German, et al.dilution, catalog number sc-6553, Santa Cruz Biotechnology), GATA3 (1:100 dilution, catalog number sc-268, Santa Cruz Biotechnology) and the ER clone EP1 (IR084, 15 µg ml−1, Dako) at the Indiana University

(7) A primate model animal revealed the inter-species differences and similarities in the subtype specifications of the spiral ganglion neuronsScientific reportsOctober 24, 2024Hosoya M, Ueno M, Shimanuki MN, Nishiyama T, Oishi N, Ozawa H.Anti-TLE4 (ms IgG1, sc365406, Santa Cruz Biotechnology, Santa Cruz, CA, USA, 1:100), Anti-GATA3 (ms IgG1, sc268, Santa Cruz Biotechnology, Santa Cruz, CA, USA, 1:50), Anti-ID1 (ms IgG2a, sc133104, Santa Cruz Biotechnology,

(8) Loss of LPAR6 and CAB39L dysregulates the basal-to-luminal urothelial differentiation program, contributing to bladder carcinogenesisCell ReportsMay 28, 2024Sangkyou Lee, Jolanta Bondaruk, Yishan Wang, Huiqin Chen, June Goo Lee, Tadeusz Majewski, Rachel D. Mullen, David Cogdell, Jiansong Chen, Ziqiao Wang, et al.proteins by Western blots: LPAR6 (Santa Cruz sc-20126), Rb (QED Bioscience 3101–3107), GATA3 (Santa Cruz sc-268), Ppar gamma (cell signaling 2435), p63 (cell signaling 13109), β-actin ( Sigma A5441), CAB39L (abcam

(9) Mutant RAS-driven Secretome Causes Skeletal Muscle Defects in Breast CancerCancer Res CommunMay 15, 2024Ruizhong Wang, Aditi S. Khatpe, Brijesh Kumar, Henry Elmer Mang, Katie Batic, Adedeji K. Adebayo, Harikrishna Nakshatrifollowing antibodies were used to characterize resulting tumors: ER (clone EP1, IR 084, Dako), GATA3 (sc-268, Santa Cruz Biotechnology), FOXA1 (sc-6553, Santa Cruz Biotechnology) and IHC was performed as described

(10) Mutant RAS-driven Secretome Causes Skeletal Muscle Defects in Breast CancerCancer Research CommunicationsMay 15, 2024Ruizhong Wang, Aditi S. Khatpe, Brijesh Kumar, Henry Elmer Mang, Katie Batic, Adedeji K. Adebayo, Harikrishna Nakshatrifollowing antibodies were used to characterize resulting tumors: ER (clone EP1, IR 084, Dako), GATA3 (sc-268, Santa Cruz Biotechnology), FOXA1 (sc-6553, Santa Cruz Biotechnology) and IHC was performed as described

(11) Evidence of steady-state fibroblast subtypes in the normal human breast as cells-of-origin for perturbed-state fibroblasts in breast cancerBreast Cancer ResearchJanuary 16, 2024Mikkel Morsing Bagger, Jonas Sjölund, Jiyoung Kim, Katharina Theresa Kohler, René Villadsen, Abbas Jafari, Moustapha Kassem, Kristian Pietras, Lone Rønnov-Jessen, Ole William Petersen,Cell Signaling/3528S,,1:1000,,M MYH11,SMMS-1,DAKO/M3558,1:50,,,M CD146/MCAM,P1H12,Abcam/Ab24577,1:500,,,M GATA3,HG3-31,Santa Cruz/sc-268,1:250,,,F2 ER,EP1,Dako/M3643,1:50,,,F2 PR,PgR636,Dako/M3569,1:100,,,F2 K5,XM26,Novocastra/NCL-L-CK5,1:250,,,M K14,LL002,Monosan/MonX10687,1:100,,,M HER2,TAB250,Invitrogen/28-0003Z,1:200,,,M AF594,Anti-mouse,Invitrogen/A21203,,1:500–1:1000,, AF568,Anti-mouse

(12) Prdm12 represses the expression of the visceral neuron determinants Phox2a/b in developing somatosensory gangliaiScienceDecember 15, 2023Vermeiren S, Cabochette P, Dannawi M, Desiderio S, San José AS, Achouri Y, Kricha S, Sitte M, Salinas-Riester G, Vanhollebeke B, et al.anti-DsRed,Takara Bio,Cat.# 632496; RRID:AB_10013483 Mouse monoclonal anti-GATA-3,Santa Cruz Biotechnology,Cat.# SC268; RRID:AB_2108591 Goat polyclonal anti-TrkB,R&D Systems,Cat.# AF1494; RRID:AB_2155264 Goat polyclonal

(13) Stromal heterogeneity may explain increased incidence of metaplastic breast cancer in women of African descentNature communicationsSeptember 14, 2023Kumar B, Khatpe AS, Guanglong J, Batic K, Bhat-Nakshatri P, Granatir MM, Addison RJ, Szymanski M, Baldridge LA, Temm CJ, et al.phospho-STAT3 (#ab30647, Abcam,1:100), Estrogen Receptor alpha (ERα, Clone EP1, Dako IR 084, 15 µg/mL), GATA3 (sc-268, Santa Cruz Biotechnology,1:100), and FOXA1 (sc-6553, Santa Cruz Biotechnology, 1:100). IHC was done

(14) Role of GATA3 in Early-Stage Urothelial Bladder Carcinoma Local RecurrenceCureusSeptember 10, 2023Hristo Popov, Peter Ghenev, George S StoyanovGmbH, Wetzlar, Germany) and with mouse monoclonal IgG anti-GATA3 (HG3-31) antibody (catalog number sc-268, Santa Cruz Biotechnology, Dallas, Texas, US) with a working dilution of 1:250, with immunoperoxidase

(15) Breast Cancer Mutations HER2V777L and PIK3CAH1047R Activate the p21–CDK4/6–Cyclin D1 Axis to Drive Tumorigenesis and Drug ResistanceCancer ResearchSeptember 1, 2023Xiaoqing Cheng, Yirui Sun, Maureen Highkin, Nagalaxmi Vemalapally, Xiaohua Jin, Brandon Zhou, Julie L. Prior, Ashley R. Tipton, Shunqiang Li, Anton Iliuk, et al.Era Antibody (D-12) (Santa Cruz Biotechnology, SC-8005), GATA-3 Antibody (Santa Cruz Biotechnology, SC-268), Cytokeratin 14 Antibody (Santa Cruz Biotechnology, SC-53253), Cytokeratin 8/18 Antibody (Fitzgerald

(16) Breast cancer mutations HER2V777L and PIK3CAH1047R activate the p21-CDK4/6 –Cyclin D1 axis driving tumorigenesis and drug resistanceCancer ResSeptember 1, 2023Xiaoqing Cheng, Yirui Sun, Maureen Highkin, Nagalaxmi Vemalapally, Xiaohua Jin, Brandon Zhou, Julie L. Prior, Ashley R. Tipton, Shunqiang Li, Anton Iliuk, et al.Era Antibody (D-12) (Santa Cruz Biotechnology, SC-8005), GATA-3 Antibody (Santa Cruz Biotechnology, SC-268), Cytokeratin 14 Antibody (Santa Cruz Biotechnology, SC-53253), Cytokeratin 8/18 Antibody (Fitzgerald

(17) Hdac1 and Hdac2 regulate the quiescent state and survival of hair-follicle mesenchymal nicheNature communicationsAugust 10, 2023Sibony-Benyamini H, Aamar E, Enshell-Seijffers D.anti-Trichohyalin (1:100*, Santa cruz # sc-98968), Mouse monoclonal anti-GATA3 (clone HG3-31) (1:200*, Santa cruz #sc-268), Rat monoclonal FITC-conjugated anti-CD34 (clone RAM34) (1:50*, eBioscience #11-0341), Rabbit polyclonal

(18) Thymine DNA glycosylase mediates chromatin phase separation in a DNA methylation-dependent mannerThe Journal of biological chemistryJuly 1, 2023McGregor LA, Deckard CE 3rd, Smolen JA, Porter GM, Sczepanski JT.(catalog no.: ab150114) were purchased from Abcam. The mouse anti-GATA3 (HG3-31) antibody (catalog no.: sc-268) was purchased from Santa Cruz Biotechnology. Methods Histone preparation and octamer refolding Recombinant

(19) Androgen Receptor Is Expressed in the Majority of Breast Cancer Brain Metastases and Is Subtype-DependentCancersMay 13, 2023Fan KY, Chehade R, Qazi M, Moravan V, Nofech-Mozes S, Jerzak KJ.status was defined as nuclear AR expression ≥10% of tumor cells. GATA3 expression was assessed using the sc-268 antibody (Santa Cruz Biotech (Dallas, TX, USA)) and Ki-67 expression was assessed using the clone 30-9

(20) Bovine blastocyst-like structures derived from stem cell culturesCell stem cellMay 4, 2023Pinzón-Arteaga CA, Wang Y, Wei Y, Ribeiro Orsi AE, Li L, Scatolin G, Liu L, Sakurai M, Ye J, Hao Ming, et al.AB_10842165" Anti-Human SOX2,BioGenex,"AN833-5M, RRID: not available" GATA3-human antibody,Santa Cruz Biotechnology,"sc-268, RRID: AB_2108591" Keratin 18,Sigma,"SAB4501665, RRID: AB_10746153" Anti-ZO-1 Monoclonal Antibody,Innovate

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GATA-3 (HG3-31) Antibody

GATA-3 (HG3-31) Antibody from Santa Cruz Biotechnology, Inc.

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Santa Cruz Biotechnology, Inc.

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GATA-3 (HG3-31) Antibody from Santa Cruz Biotechnology, Inc.

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