CENP-B (2D-7) Antibody from Santa Cruz Biotechnology, Inc.

Yes, the CENP-B (2D-7) Antibody has been utilized in immunofluorescence applications to investigate centromere protein localization and dynamics in human cells, as evidenced by its use in studies examining chromosomal aberrations and genomic stability.

The CENP-B antibody has been cited in research focusing on chromosomal aberrations in cancer, particularly in studies investigating the role of the SETD2 tumor suppressor in preventing isochromosome formation, which is relevant to understanding genomic instability in cancer cells.

The CENP-B (2D-7) Antibody is reactive with mouse, human, and rat samples, making it suitable for a variety of experimental models across these species.

The CENP-B antibody has been employed in cell and metaphase spread immunofluorescence techniques to visualize centromere proteins, contributing to the understanding of chromosomal structures and abnormalities, such as isodicentric chromosomes, in cytogenetic research.