HSC 70 (B-6) Antibody sc-7298 from Santa Cruz Biotechnology, Inc.

Product Specs
ItemHSC 70 (B-6) Antibody
CompanySanta Cruz Biotechnology, Inc.
Price $316.00Supplier Page View Company Product Page
Catalog Numbersc-7298
Antibody TypePrimary Antibodies
NCBI Gene AliasesHEL-33, NIP71, Hspa10, LAP-1, Hsc73, Hsc70, Hsc71, HSC54, HSC71, LAP1, HSPA10, 2410008N15Rik, HSP71, HEL-S-72p, Hsp73, HSP73, HSC70
Quantity200 µg/ml
CloneB-6
Reactivitymouse, rat, human
ApplicationsWB, IP, IF, IHC(P), FCM, ELISA
Conjugate/TagUnconjugated
FormatPurified
ClonalityMonoclonal
Hostmouse
NCBI Full Gene Nameheat shock protein 8, heat shock protein family A (Hsp70) member 8
TargetHSC 70
IsotypeIgG2a

Questions and Answers

What applications has the HSC 70 (B-6) antibody been used for in scientific research?

The HSC 70 (B-6) antibody has been shown to work in various applications including Western blotting, ELISA, flow cytometry, immunofluorescence, immunohistochemistry, and immunoprecipitation.

Can this antibody be used to study the role of HSC70 in cancer research?

Yes, the HSC 70 (B-6) antibody has been utilized in studies related to cancer, such as its role in glioblastoma cells where it was involved in stabilizing oncogenic proteins, thereby influencing tumor aggressiveness and cancer stem cell properties.

Is the HSC 70 (B-6) antibody effective in detecting HSC70 levels in different species?

The antibody is reactive with mouse, human, and rat samples, making it suitable for studies across these species.

How has the HSC 70 (B-6) antibody been referenced in recent publications?

The HSC 70 (B-6) antibody has been cited in numerous studies, including those investigating mechanisms of drug resistance in neuroblastoma and the regulation of actin cytoskeleton organization in Sertoli cells, highlighting its versatility in various research contexts.

Santa Cruz Biotechnology, Inc.

10410 Finnell Street

Dallas, Texas 75220

United States

Phone: 1-800-457-3801
831-457-3801

Company Profile

Website: http://www.scbt.com/

(1) EctoShed: a novel gene delivery platform for functional analysis of adipocyte-shed proteoformsBMC Res NotesMay 7, 2026Ana Rita Tavanez, Nadia Meincke Egedal, Natasa Stanic, Hande Topel, Jan-Wilhelm Kornfeld(iBlot 2, Invitrogen). Membranes were blocked and probed with primary antibodies (anti-HSC70 1:2000 (sc-7298, Santa Cruz Biotechnology), anti-GFP 1:1000 (a11122, Invitrogen) and anti-AOC3 1:2000 (ab187202, Abcam)

(2) The NHSL1-A complex interacts with the Arp2/3 complex and controls cell migration efficiency and chemotaxisbioRxivApril 11, 2026Shamsinar Jalal, Tommy Pallett, Sheng-yuan Wu, Sreeja B. Asokan, James E. Bear, Matthias Krause(Cell Signaling 4738 or Abcam ab151289), Scar/WAVE2 rabbit mAb (D2C8, CST 3659), HSC70 (Santa Cruz sc7298). Secondary antibodies: HRP-anti-rabbit (7074S), HRP-anti-mouse (7076S) (Cell Signaling Technology).

(3) Endogenous promoter G-quadruplexes scaffold apurinic/apyrimidinic endonuclease (APE1) to drive gene expressionNucleic Acids ResApril 2, 2026Yingling Chen, Bhopal Mohapatra, Suravi Pramanik, Mason Tarpley, Achyuth Kalluchi, Sutapa Ray, Kyle Hewitt, M Jordan Rowley, Vimla Band, Kishor K BhakatCat# 3879), c-Jun (Cell Signaling Technology, Cat# 9165), and HSC70 (Santa Cruz Biotechnology, Cat# sc-7298). Blots were developed using horseradish peroxidase (HRP)-conjugated secondary antibodies (Jackson ImmunoResearch)

(4) Increased Protein Synthesis With Reduced Endoplasmic Reticulum Stress Defines a Specific Adaptation in Pancreatic Acinar MetaplasiaGastro Hep AdvancesMarch 20, 2026Maxime Libert, Sophie Quiquempoix, Leyre López-Muneta, Ludivine Wacheul, Sabine Cordi, Christiane Zorbas, Patrick Jacquemin,BD Biosciences (610154) Amylase,Mouse,1:500,–,Santa Cruz (sc-46657) HSC70,Mouse,–,1:1000,Santa Cruz (sc-7298) "Antimouse IgG, HRP-linked",Horse,–,1:5000,Cell Signaling (7076) "Antirabbit IgG, HRP-linked",Goat,–,1:5000,Enzo Life Sciences

(5) Lysosome-targeting live attenuated influenza vaccines elicit robust and broad immunity in miceNat CommunMarch 18, 2026Jiawei Hao, Ping Wang, Quan Shen, Xuetong Xi, Le Tong, Jihuan Hou, Le Li, Qikai Wang, Chengyao Liu, Jing Li, et al.antibody (MBL, Cat# PM020; 1:1000 dilution) and anti-HSC70 antibody (Santa Cruz Biotechnology, Cat# sc-7298; 1:300 dilution) or anti-LAMP2A antibody (Santa Cruz Biotechnology, Cat# sc-18822; 1:300 dilution) diluted

(6) Overexpression of the ERG oncogene in prostate cancer identifies candidates for PARP inhibitor-based radiosensitizationJournal of Clinical InvestigationMarch 16, 2026Sabrina Köcher, Mohamed E. Elsesy, Ayham Moustafa, Wahid Mohammadi, Adriana Perugachi Heinsohn, Yamini Nagaraj, Su Jung Oh-Hohenhorst, Jan Hahn, Bente Siebels, Thomas Mair, et al.(Santa Cruz Biotechnology catalog sc-47778, RRID:AB_626632) and HSC70 (Santa Cruz Biotechnology catalog sc-7298, RRID:AB_627761) were used as loading controls. siRNA transfection for ERG knockdown VCaP cells in

(7) The P2X4 purinergic receptor controls the autophagy-related release of small extracellular vesicles from mammary cancer cells under hypoxiaCell Communication and SignalingMarch 14, 2026Thomas Duret, Mohammed Elmallah, Audrey Heraud-Meley, Cloé Tessier, Ana Valeria Vinhais Da Silva, Stéphanie Chadet, Roxane Lemoine, Justine Gainche, Valérie Labas, Ana-Paula Teixeira-Gomes, et al.B,CAB4069 (Assay genie),WB,1/2000 β-actin,"sc-47,778 (Santa Cruz Biotechnology)",WB,1/1000 HSC70,sc-7298 (Santa Cruz Biotechnology),WB,1/1000 mouse IgG-HRP,"Cat. 1,706,516 (Biorad)",WB,"1/10,000" rabbit

(8) ISGylation of γH2AX retains MDC1 and facilitates homologous recombination repair causing radioresistance in esophageal adenocarcinomaJournal of Biological ChemistryMarch 9, 2026Archismaan Ghosh, Paramita Ray, Dafydd Thomas, Vinay Jeeyar, Shreya Pillai, Venkatesha Basrur, Irina V. Bondarenko, Emily Bellile, David H. Wang, Meredith A. Morgan, et al.included anti-DDK (OTI4C5; Origene Technologies), anti-GFP (JL-8; Takara Bio, Fitchburg, WI) and Hsc70 (sc-7298) were from Santa Cruz Biotechnology. The RAD51 antibody was purchased from SigmaMillipore (Cat# PC130)

(9) Male obesity causes adipose mitochondrial dysfunction in F1 mouse progeny via a let-7-DICER axisNature CommunicationsFebruary 24, 2026Chien Huang, Joo-Hyun Park, Ali Altıntaş, Natasa Stanic, Kristine Kyle de Leon, Signe Isacson, Panagiotis Kalogeropoulos, Hande Topel, Tobias Madsen, Sebastian Zanner, et al.(Cell Signaling Technologies #60322, 1:1,1000 dilution). Relative protein quantification was normalized by HSC70 (Santa Cruz sc-7298, 1:1000 dilution) or HSP90 (Cell Signaling Technologies #4877, 1:1000 dilution). Access to reagents All

(10) MLKL in liver parenchymal cells promotes liver cancer in murine metabolic dysfunction-associated steatotic liver diseaseCell Death & DiseaseFebruary 19, 2026Ghiles Imerzoukene, Ghania Hounana Kara-Ali, Céline Heitz-Marchaland, Thibaut Larcher, Mélanie Simoes Eugénio, Annaïg Hamon, Aurore Bidon, Gevorg Ghukasyan, Laurence Dubreil, Nicolas Loiseau, et al.anti-pMLKL (#37333, 1:250, Cell Signaling, The Netherlands) or for 1.5 h at 20 °C with anti-HSC70 (#sc-7298, 1:5000, Santa Cruz, USA), followed by HRP-conjugated secondary antibody. Signals were detected by ECL

(11) Overexpression of the ERG oncogene in prostate cancer identifies candidates for PARP inhibitor–based radiosensitizationJ Clin InvestFebruary 3, 2026Sabrina Köcher, Mohamed E. Elsesy, Ayham Moustafa, Wahid Mohammadi, Adriana Perugachi Heinsohn, Yamini Nagaraj, Su Jung Oh-Hohenhorst, Jan Hahn, Bente Siebels, Thomas Mair, et al.(Santa Cruz Biotechnology catalog sc-47778, RRID:AB_626632) and HSC70 (Santa Cruz Biotechnology catalog sc-7298, RRID:AB_627761) were used as loading controls. siRNA transfection for ERG knockdown VCaP cells in

(12) Infosomes as Inflammatory Mediators: Proteomic Profiling of Proteins Enriched in Inflammatory Extracellular VesiclesMolecular & Cellular ProteomicsFebruary 1, 2026Semin Lee, Minjun Kim, Seungmin Lee, Hyo-Jin Kim, Ki-Jun Ryu, Sang-Hun Kim, Hong-Yeoul Ryu, Kyunghee Lee, Kwang Dong Kim, Jiyun Yoo, et al.Inc.; Cat. No. #3878), Heat Shock Protein Family A Member 8 (HSPA8) (Santa Cruz Biotechnology Cat. No. SC-7298), TSG101 (Abcam Limited; Cat. No. ab125011), GAPDH (Cell Signaling Technology, Inc.; Cat. No. #2118),

(13) FAM134B controls collagen I dynamics in hepatic stellate cell-driven fibrosisAmerican Journal of Physiology-Gastrointestinal and Liver PhysiologyFebruary 1, 2026Jagannath Misra, Zachary Hanquier, Reese Baxter, Nipuni Barupala, Alexander Jackson, Jessica L. MaiersRRID:AB_444365), GAPDH at 1:3000 (Thermo Fisher AM4300, RRID:AB_2536381), HSC70 at 1:3000 (Santa Cruz sc-7298), LC3A/B at 1:1000 (Cell Signaling Technologies D3U4C, RRID:AB_2617131), and sXBP1 at 1:1000 (Cell Signaling

(14) Association-induced folding governs surrogate light chain and pre-B cell receptor core assemblyNature CommunicationsJanuary 30, 2026Jasmin König, Natalia Catalina Sarmiento Alam, Ruiming He, Nicolas Blömeke, Olga Sieluzycka, Florian Rührnößl, Maximilian Riedl, Bernd Reif, Matthias J. Feige, Johannes Buchner(9023) anti-HA (902302, Biolegend, Koblenz, Germany) at 1:1000; mouse monoclonal (B-6) anti-Hsc70 (sc-7298, Santa Cruz, Heidelberg, Germany) at 1:1000 and mouse monoclonal anti-V5 (680602, Biolegend, Koblenz,

(15) NAD+ and Sirt5 restore mitochondrial bioenergetics failure and improve locomotor defects caused by sucla2 mutationsJCI InsightJanuary 23, 2026Joy Richard, Giulia Lizzo, Noélie Rochat, Adrien Jouary, Pedro T.M. Silva, Alice Parisi, Stefan Christen, Sofia Moco, Michael B. Orger, Philipp Gutanti-succinyl-lysine (PTM Biolabs, PTM-401), Sucla2 (Abcam, ab183513), Hsc-70 (Santa Cruz Biotechnology, sc-7298), tubulin (Abcam, ab6046), and Vdac1 (Abcam, ab15895) were used as primary antibodies. Anti-rabbit and

(16) Deciphering acquired resistance mechanisms to sustained auxin-inducible protein degradation in cells and micebioRxivJanuary 16, 2026Judith Hyle, Zhenling Liu, Shaela Fields, Jifeng Yang, Xinyan Chen, Wenjie Qi, Qiong Zhang, Byoung-Kyu Cho, Young Ah Goo, Xiuling Li, et al.C15410210–50; CTCF, Millipore, 07729; miniAID, MBL, M214–3; GFP, Santa Cruz, sc-9996; HSC70, Santa Cruz, sc-7298; HA, Cell Signaling, 3724S). Membranes were washed in TBS-T and then incubated with secondary antibodies

(17) NOTCH1 intracellular domain stabilization by MDM2 plays a major role in NSCLC response to platinumEMBO Molecular MedicineJanuary 16, 2026Sara Bernardo, Lisa Brunet, Quentin Dominique Thomas, David Bracquemond, Céline Bouclier, Marie Colomb, Maicol Mancini, Eric Fabbrizio, Alba Santos, Sylvia-Fenosoa Rasamizafy, et al.(sc-126 Santa Cruz Technology, 1:1000), TBP (TFIID sc-56794, Santa Cruz Technology, 1:500), HSC70 (sc-7298 Santa Cruz Technology, 1:1000), and HEY1 (#19929 Proteintech 1:1000). Secondary antibodies were horseradish

(18) Tet2 deficiency promotes IgG1+ B‐cell expansion and differentiation blockade through deregulation of the Nfkbia –c‐Rel axisHemaSphereJanuary 13, 2026Hussein Ghamlouch, Michaël Degaud, Veronique Della‐Valle, Alexandre Eeckhoutte, Marine Armand, Amina Joudat, Camille Decaudin, Pilar M. Dominguez, Wojciech Rosikiewicz, Patrycja Pawlikowska, et al.with the following primary antibodies: anti‐c‐Rel (sc‐6955; Santa Cruz Biotechnology) and anti‐HSC70 (sc‐7298; Santa Cruz Biotechnology). HSC70 protein was used as an internal control. HRP‐conjugated antibody (anti‐mouse;

(19) KRAS mutated lung adenocarcinoma responds to pan-ERBB and Aurora kinase inhibitorsnpj Precision OncologyJanuary 12, 2026Iris Z. Uras, Marija V. Trkulja, Abdelrahman K.A.A. Salama, Jaqueline Horvath, Khushi Asnani, Christoph Trenk, Stefan Kubicek, Martin Bilban, Herwig P. Moll, Emilio CasanovaCell Signaling 9308), phospho-AKT (S473, Cell Signaling #9271) and AKT (Cell Signaling #9272). HSC70 (Santa Cruz sc-7298) and ß-Actin (Santa Cruz sc-47778) were used as a loading control. Clonogenic assay Cells were seeded

(20) Plasma extracellular vesicle sampling from Glioblastoma demonstrates a small RNA signature indicative of disease and identifies lncRNA RPPH1 as a biomarkerNeuro-Oncology AdvancesJanuary 7, 2026Jae Ho Ho Han, Gabriel Wajnberg, Kathleen M Attwood, Lindsay Noiles, Brandon Hannay, Robert Cormier, Simi Chacko, Maya Willms, Andrea L O Hebb, Mary V Macneil, et al.Primary antibodies were prepared in TBST with 5% skim milk: Hsc-70 (1:200, Santa Cruz Biotechnology Cat# SC-7298, RRID: AB_627761), CD63 (1:200, Santa Cruz Biotechnology Cat# SC-5275, RRID: AB_627877), FLOT1 (1:1000,

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2/22/2021Anti-HSC70 Antibody Works Great for Immunoblotting Chao YangWe have been using this antibody for Immunoblotting to detect HSC70 as loading control in various cell lines .

HSC 70 (B-6) Antibody

HSC 70 (B-6) Antibody from Santa Cruz Biotechnology, Inc.

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Santa Cruz Biotechnology, Inc.

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HSC 70 (B-6) Antibody from Santa Cruz Biotechnology, Inc.

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