MMP-3 (1B4) Antibody sc-21732 from Santa Cruz Biotechnology, Inc.

Product Specs
ItemMMP-3 (1B4) Antibody
CompanySanta Cruz Biotechnology, Inc.
Price $316.00Supplier Page View Company Product Page
Catalog Numbersc-21732
Quantity200 µg/ml
Reactivitymouse, rat, human
ApplicationsWB, IP, IF, IHC(P)
Conjugate/TagUnconjugated
FormatPurified
Antibody TypePrimary Antibodies
Clone1B4
Hostmouse
TargetMMP-3
IsotypeIgG1
NCBI Gene AliasesEMS-2, STR-1, MMP-3, SLN1, Stmy1, Str1, SLN-1, SL-1, CHDS6, STMY1, STMY, STR1
ClonalityMonoclonal
NCBI Full Gene Namematrix metallopeptidase 3

Questions and Answers

Can this antibody be used to study the role of MMP-3 in cardiac hypertrophy?

Yes, the MMP-3 (1B4) Antibody has been shown to be effective in studies investigating cardiac hypertrophy. For instance, in a study examining IL-18-induced hypertrophy in H9c2 cardiomyoblasts, MMP-3 expression was upregulated, and its inhibition was linked to the attenuation of hypertrophic signaling pathways ().

Is this antibody suitable for use in Western blotting applications?

The MMP-3 (1B4) Antibody has been utilized in Western blotting, as evidenced by its application in various studies, including those assessing MMP-3 levels in different experimental contexts (, ).

What species can this antibody react with, and is it validated for use in multiple applications?

This antibody is reactive with mouse, human, and rat species. It has been validated for use in several applications, including Western blotting, immunofluorescence, immunohistochemistry, and immunoprecipitation, making it versatile for various experimental setups (, ).

Are there any specific findings related to MMP-3 that this antibody has helped uncover in cancer research?

Yes, the MMP-3 (1B4) Antibody has been used in studies that explore its role in cancer progression. For example, in breast cancer research, overexpression of ECM1 was found to increase MMP-3 levels, which is associated with enhanced cancer cell invasion and migration ().

Santa Cruz Biotechnology, Inc.

10410 Finnell Street

Dallas, Texas 75220

United States

Phone: 1-800-457-3801
831-457-3801

Company Profile

Website: http://www.scbt.com/

(1) Interleukin-1β-induced arthritis involves chondrocyte oxiapoptophagyThe Korean Journal of Physiology & PharmacologyMay 1, 2026Jeong-Yeon Seo, Do Kyung Kim, HyangI Lim, Kyeong-Rok Kang, Hong Sung Chun, Ji-Su Oh, Jae-Sung Kimpurchased from Santa Cruz Biotechnology were used in present study: matrix metalloproteinase (MMP)-3 (SC-21732, 57 kDa), β-actin (SC-47778, 43 kDa), CH25H (SC-293256, 36 kDa), Fas ligand (FasL, SC-19681, 40 kDa),

(2) Metabolomics Reveals the Anti-hepatic Fibrosis Mechanisms of Pueraria lobata (Willd.) Ohwi Extract and Potential Metabolites AlterationsInternational Journal of Medical SciencesMarch 17, 2026Yu-Ju Chen, Lo-Yun Chen, Ngoc-Thac Pham, John Louie Dela Vega, Federica Fulgheri, Ching-Chiung Wang, Maria Letizia Manca, Chia-Jung Leesc-8422), Collagen Type I (Proteintech, 14695-1-AP), α-SMA (Proteintech, 14395-1-AP), MMP-3 (Santa Cruz, sc-21732), MMP-8 (Santa Cruz, sc-8848), MMP-13 (Cell Signaling, #94808), Nrf2 (Cell Signaling, #20733), and HO-1

(3) Unravelling the Contribution of Matrix Metalloproteinase-3 Genotype-Phenotype to Pterygium RiskCancer Genomics ProteomicsMarch 1, 2026Hung-Chih Chen, Ning-Yi Hsia, Chung-Lin Tsai, Te-Chun Hsia, Pei-Shin Hu, Yun-Chi Wang, Hou-Yu Shih, Wen-Shin Chang, Jiunn-Cherng Lin, DA-Tian Bau, et al.non-fat milk and incubated overnight at 4°C with a monoclonal anti-human MMP-3 antibody (1:1,000; Cat. sc-21732, Santa Cruz Biotechnology, Dallas, TX, USA). Following this, the membrane was exposed to a horseradish

(4) Physalin A Suppresses Human Oral Squamous Carcinoma Cell Migration and Invasion Through Inhibiting Grb2/Ras and MMP/uPA Signaling PathwaysIn VivoMarch 1, 2026YI-SHIH MA, FU-SHIN CHUEH, YUEH-HSIUNG KUO, YU-SHENG HSIEH, SUNG-NIEN YU, JIANN-YEU CHEN, WEI-YONG LIN, JAW-CHYUN CHEN, CHIU-YING CHEN, WEN-TSONG HSIEH, et al.Santa Cruz Biotechnology), -MMP-1 (sc-21731; Santa Cruz Biotechnology), -MMP-2 (sc-13595; Santa Cruz Biotechnology), -MMP-3 (sc-21732; Santa Cruz Biotechnology), -MMP-9 (sc-393859; Santa Cruz Biotechnology), -tissue inhibitor of metalloprotease

(5) Fermented Clostridium butyricum GKB7 Inhibits Osteoarthritis Induced by Anterior Cruciate Ligament Transection in a Preclinical ModelInternational Journal of Medical SciencesFebruary 18, 2026Wei-Cheng Chen, Li-Chai Chen, You-Shan Tsai, Yen-Po Chen, Yen-Lien Chen, Chin-Chu Chen, Yen-You Lin, Tzu-Ching Chang, Chen-Ming Su, Chih-Hsin Tangprovided the aggrecan (ab3778) antibody. Santa Cruz Biotechnology (Dallas, TX, USA) provided the MMP-3 (SC-21732) and MMP-13 (SC-30073) antibodies. We purchased TNF-α (A11534), COL2A1 (A1560), and ADAMTS5 (A2836)

(6) Efficacy of Combined Hericium erinaceus Mycelium and Undenatured Type II Collagen in Reducing Osteoarthritis Progression in a Preclinical Animal ModelInternational Journal of Medical SciencesJanuary 23, 2026Kun-Tsan Lee, Chin-Jung Hsu, Li-Chai Chen, Li-Ya Lee, Wan-Ping Chen, Yu-Wen Chen, Chin-Chu Chen, Yen-You Lin, Tzu-Ching Chang, Chen-Ming Su, et al.and Methods Materials Aggrecan (ab3778) antibody was obtained from Abcam (Cambridge, UK). MMP-3 (SC-21732) and MMP-13 (SC-30073) antibodies were obtained from Santa Cruz Biotechnology (Dallas, TX, USA). TNF-α

(7) Oral administration of soybean okara extract reduces osteoarthritis pain and progression in ratsInternational Journal of Medical SciencesJanuary 1, 2026Kun-Tsan Lee, Chien-Min Chen, Chih-Hsin Tang, Yen-You Lin, Tzu-Ching Chang, Min-Huan Wu, Sunny Li-Yun Chang(Minneapolis, MN, USA); TNF-α (A11534) and collagen II (A1560) from ABclonal, Inc. (Woburn, MA, USA); MMP-3 (SC-21732) from Santa Cruz Biotechnology (Dallas, TX, USA); and aggrecan (ab3778) from Abcam (Cambridge, UK).

(8) Integration of Network Pharmacology, Molecular Docking, and Experimental Validation to Identify the Effect of EGCG on Alleviating Chondrocyte Inflammatory Damage by Targeting ER Stress-STAT3 CrosstalkJ Inflamm ResOctober 30, 2025Min-Jun Zhao, Jian-Li Yin, Jia-Hui Luo, Yang-Shuo Ge, Chun-Meng Huang, Ting-Ting Meng, Xue-Zong Wang, Xin-Hui Huang, Liao-Lin Chen, Yu-Qing Zhai, et al.USA). Primary antibodies against COL2A1 (sc-28887), MMP13 (sc-30073), Matrix Metallopeptidase 3 (MMP3) (sc-21732), and SRY-box transcription factor 9(SOX9) (sc-20095) were obtained from Santa Cruz Biotechnology (Santa

(9) Integration of Network Pharmacology, Molecular Docking, and Experimental Validation to Identify the Effect of EGCG on Alleviating Chondrocyte Inflammatory Damage by Targeting ER Stress-STAT3 CrosstalkJournal of Inflammation ResearchOctober 30, 2025Min-Jun Zhao, Jian-Li Yin, Jia-Hui Luo, Yang-Shuo Ge, Chun-Meng Huang, Ting-Ting Meng, Xue-Zong Wang, Xin-Hui Huang, Liao-Lin Chen, Yu-Qing Zhai, et al.USA). Primary antibodies against COL2A1 (sc-28887), MMP13 (sc-30073), Matrix Metallopeptidase 3 (MMP3) (sc-21732), and SRY-box transcription factor 9(SOX9) (sc-20095) were obtained from Santa Cruz Biotechnology (Santa

(10) Bioactive Silk Fibroin Hydrogel Harnesses BMSCs‐EVs to Modulate Inflammatory Microenvironment in Intervertebral Disc DegenerationJournal of Extracellular VesiclesSeptember 3, 2025Qi Liu, Jiaying Luo, Huan Wang, Shaoqian Cuiblocked with 5% BSA for 1 h. Cells were incubated overnight with primary antibodies against MMP3 (1:300, sc‐21732, Santa Cruz Biotechnology) and MMP13 (1:300, GB11247‐100, Servicebio). The next day, cells were incubated

(11) Impact of intra-articular high-concentration hyaluronic acid administration on the innate immune response in experimental knee osteoarthritisBMC musculoskeletal disordersAugust 12, 2025Herrero-Beaumont G, Marco-Bonilla M, Migliore A, López-Reyes A, Irigaray-Moreno A, Mediero A, Largo R.anti MMP-1 antibody MAB 901, 1:200 dilution, R&D Systems, Minneapolis, MN, USA; anti MMP-3 antibody sc-21732, 1/200 dilution, Santa Cruz Biotech, Santa Cruz, CA, USA). Membranes were blocked for 30 min at room

(12) Targeting hyaluronan synthesis enhances the therapeutic effectiveness of biologics in inflammatory bowel diseaseJCI InsightJanuary 9, 2025Peng Xiao, Zhehang Chen, Xuechun Cai, Wenhao Xia, Xia Liu, Zhangfa Song, Huijuan Wang, Yuening Zhao, Youling Huang, Yu Zhang, et al.(33). The following antibodies were used: anti-HAS2 (sc-514737, Santa Cruz Biotechnology), anti-MMP3 (sc-21732, Santa Cruz Biotechnology), anti-phospho STAT3 (9145, Cell Signaling Technology), anti–β-Actin (4970S,

(13) Transcriptome Analysis of Platelet‐Rich Plasma–Treated Osteoarthritic ChondrocyteBioMed Research InternationalNovember 21, 2024Dae Keun Suh, Woo Jin Yeo, Kuhoang Cheong, Jae-Won Heo, Dong Hyeon Kim, Soo Mi Lee, Yong-Soo Lee, Dong Won Suhtransferred to a polyvinylidene fluoride (PVDF) membrane. The membranes were probed with anti-MMP3 (sc21732, Santa Cruz Biotechnology, Dallas, TX, USA), anti-11β-HSD1 (AF3397, R&D system, Minneapolis, MN, USA),

(14) IL-32γ Induced Autophagy Through Suppression of MET and mTOR Pathways in Liver Tumor Growth InhibitionInternational Journal of Molecular SciencesOctober 30, 2024Ji-Won Seo, Yong-Sun Lee, In-Sook Jeon, Ji-Eun Yu, Jun-Sang Yoo, Ja-Keun Koo, Dong-Ju Son, Jae-Suk Yoon, Sang-Bae Han, Do-Young Yoon, et al.#sc-9857), Bcl-2 (dilution 1:1000; #sc-7382), Bax (dilution 1:1000; #sc-7480), MMP3 (dilution 1:1000, #sc-21732), PCNA (dilution 1:1000; #sc-9857), β-actin (dilution 1:1000; #sc-47778 purchased from Santa Cruz Biotechnology,

(15) The joint protective function of live- and dead-Lactobacillus plantarum GKD7 on anterior cruciate ligament transection induces osteoarthritisAging (Albany NY)September 30, 2024Yen-You Lin, Chih-Ying, Wu, You-Shan Tsai, Chin-Chu Chen, Tzu-Ching Chang, Li-Chai Chen, Hsien-Te Chen, Chin-Jung Hsu, Chih-Hsin Tangfinal dilution of 1:200) antibody were bought from ABclonal, Inc. (Woburn, MA, USA). MMP3 antibody (SC-21732; final dilution of 1:100) was bought from Santa Cruz Biotechnology (Dallas, TX, USA). Aggrecan antibody

(16) Time-Dependent Effect of Eggshell Membrane on Monosodium-Iodoacetate-Induced Osteoarthritis: Early-Stage Inflammation Control and Late-Stage Cartilage ProtectionNutrientsJune 14, 2024Min Yu, Cheoljin Park, Young Bae Son, So Eun Jo, Seong Hee Jeon, Ye Jin Kim, Sang Bae Han, Jin Tae Hong, Dong Ju Sonthe membranes were probed with primary antibodies against: matrix metalloproteinase (MMP)-3 (Cat No. sc-21732; 1:1000, Santa Cruz biotechnology, Dallas, TX, USA), MMP-13 (Cat No. 8165-1-AP; 1:1000, Proteintech),

(17) SPARCL1 promotes chondrocytes extracellular matrix degradation and inflammation in osteoarthritis via TNF/NF-κB pathwayJournal of Orthopaedic TranslationMay 28, 2024Yu Miao, Shenghui Wu, Ziling Gong, Yiwei Chen, Feng Xue, Kexin Liu, Jian Zou, Yong Feng, Guangyi LiProteins were analyzed with antibodies against matrix metalloproteinases 3 (MMP3) (1:1000, Santa Cruz Cat# sc-21732), ADAMTS5 (1:1 000, Affinity Cat# DF13268), FAK (1:1000, Cell Signaling Technology Cat# 3285), Phospho-FAK

(18) Elevated extracellular matrix protein 1 in circulating extracellular vesicles supports breast cancer progression under obesity conditionsNature communicationsFebruary 24, 2024Xu K, Fu A, Li Z, Miao L, Lou Z, Jiang K, Lau C, Su T, Tong T, Bao J, et al.Santa Cruz, sc365335), integrin β2 (1:1000, Cell Signaling Technology, #47985) MMP3 (1:600, Santa Cruz, sc-21732), S100A/B (1:1000, Novus Biologicals, NBP2-29403), GPX3 (1:500, Abcam, ab256470), ICAM-1(1:600, Santa Cruz

(19) Knockdown of DAPK1 inhibits IL-1β-induced inflammation and cartilage degradation in human chondrocytes by modulating the PEDF-mediated NF-κB and NLRP3 inflammasome pathwayInnate immunityJanuary 1, 2024Zhao Z, Liu W, Cheng G, Dong S, Zhao Y, Wu H, Cao Z.

(20) The effect of oral administration of undenatured type II collagen on monosodium iodoacetate-induced osteoarthritis in young and old ratsScientific reportsApril 20, 2023Sahin E, Orhan C, Erten F, Saiyed Z, Azari EK, Durkee S, Sahin K.(Santa Cruz Bio., IL-1β; sc-52012, IL-6; sc-57315, IL-10; sc-365858, TNF-α; sc-52746, NF- κB; sc-8008, MMP3; sc-21732, COMP; sc-374660, and Abcam COX2; ab283593, collagen type 2; ab34712, TGF-β; ab215715). Then, the membranes

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MMP-3 (1B4) Antibody

MMP-3 (1B4) Antibody from Santa Cruz Biotechnology, Inc.

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Santa Cruz Biotechnology, Inc.

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MMP-3 (1B4) Antibody from Santa Cruz Biotechnology, Inc.

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