c-Myc (C-33) Antibody sc-42 from Santa Cruz Biotechnology, Inc.

Product Specs
Itemc-Myc (C-33) Antibody
CompanySanta Cruz Biotechnology, Inc.
Price $316.00Supplier Page View Company Product Page
Catalog Numbersc-42
Quantity200 µg/ml
Reactivitymouse, rat, human, avian
ApplicationsWB, IP, IF, ELISA
Conjugate/TagUnconjugated
FormatPurified
Antibody TypePrimary Antibodies
CloneC-33
Hostmouse
Targetc-Myc
IsotypeIgG1
NCBI Gene Aliasesc-Myc, bHLHe39, MRTL, MYCC, Nird, Myc2, Niard
ClonalityMonoclonal
NCBI Full Gene Namemyelocytomatosis oncogene, MYC proto-oncogene, bHLH transcription factor

Questions and Answers

Can this c-Myc antibody be used for Western blotting in human cancer cell lines?

Yes, the c-Myc (C-33) antibody has been successfully utilized in Western blotting to detect endogenous c-Myc levels in various human cancer cell lines, as demonstrated in studies such as those by Henriksson et al. (2022) and Gan et al. (2010).

Is this antibody effective for immunofluorescence applications in stem cell research?

The c-Myc antibody has been shown to work in immunofluorescence applications, particularly in studies involving pluripotent stem cells, where it plays a crucial role in assessing c-Myc expression levels during differentiation processes.

What species can this antibody react with, and has it been cited in relevant research?

This antibody is reactive with mouse, chicken, human, and rat species. It has been cited in 344 scientific articles, indicating its widespread use and relevance in various research contexts, including studies on tumor biology and stem cell differentiation.

Has this antibody been used in studies related to cancer treatment resistance?

Yes, the c-Myc antibody has been referenced in studies investigating the role of c-Myc in cancer treatment resistance, such as the work by Biamonte et al. (2019), which explored how c-Myc downregulation is associated with chemoresistance in epithelial ovarian cancer.

Santa Cruz Biotechnology, Inc.

10410 Finnell Street

Dallas, Texas 75220

United States

Phone: 1-800-457-3801
831-457-3801

Company Profile

Website: http://www.scbt.com/

(1) HERC1 oncogene enhances stemness and tumorigenic potential in CD44+-derived organoids of head and neck squamous cell carcinoma through IL-6/STAT3 signalingOncogeneMay 26, 2026Eunjin Jeong, Hye Lin Kim, Seohee Park, Seojin Jang, Jamin Ku, Hajeong Kim, Haeun Kim, Seo Lyn Choi, Kang Pa Lee, Suji Baek, et al.(Cat. A22625, Abclonal), Sox-2 (Cat. 23064, Cell Signaling), Oct4 (Cat. A7920, Abclonal), c-Myc (Cat. sc-42, Santa Cruz; Cat. AB32072, Abcam), Slug (Cat. 9585, Cell Signaling), Snail (Cat. 5243, Abclonal), Zeb1

(2) PrP C Glycoprotein Modulates Atmospherically Relevant Artificial Particulate Matter-Induced Development of Lung Cancer in MiceEnvironmental Science & TechnologyApril 7, 2026Thi Thu Trang Kieu, Hyun-Jaung Sim, Govinda Bhattarai, Han-Sol So, Jeong-Chae Lee, Sung-Ho Kookblocking serum. Tissue slides were incubated overnight at 4 °C with specific antibodies, including c-Myc (sc-42-Santa Cruz Biotechnology), Sox2 (sc-365823-Santa Cruz Biotechnology), TTF1 (sc-53136-Santa Cruz Biotechnology),

(3) Ring Finger Protein 1, a Novel Ubiquitin E3 Ligase Targeting Cancerous Inhibitor of Protein Phosphatase 2A to Suppress Smoking-Induced Lung TumorigenesisMedComm (2020)December 7, 2025In-Ho Jeong, Jae Kwang Yun, Jun‐O. Jin, Geun Dong Lee, Peter Chang-Whan Lee(#4129, Cell Signaling Technologies), anti‐CyclinB1 (#SC‐752, Santa Cruz Biotechnology), anti‐c‐MYC (#SC‐42, Santa Cruz Biotechnology), anti‐PP2Ac (#2038, Cell Signaling Technologies), anti‐MYC tag (#SC‐40, Santa Cruz Biotechnology

(4) Investigating the Impact of the Secretome From hAMSCs on HT-29 Colon Cancer Cells via TNF-α/TGF-β/c-MYC Signaling Pathways Using a Three-Dimensional Cell Culture ModelImmun Inflamm DisOctober 15, 2025Mohammad Ali Majdoddin, Fatemeh SafariSanta Cruz Biotechnology: anti‐cyclin B1 (GNS1: sc‐245), anti‐β‐actin (C4: sc‐47778), anti‐c‐MYC (C‐33: sc‐42), anti‐MMP9 (E‐11:sc‐393859), anti‐p21 (F5: sc‐6246), anti‐p15 INK4B (D12: sc‐271791), anti‐CDK4 (DCS‐35:

(5) TTK Defines a High-Risk Oral Squamous Cell Carcinoma Subtype Through Dual mTORC1/NF-κB ActivationInt Dent JOctober 14, 2025Huan Jin, Tianjie Liu, Yucheng Guo, Wenqing Bu, Fei Liu, Yuxia Hou(CST, #2697), Anti-IKBα (CST, #4812), Anti-p-IKBα (CST, #2859), Anti-c-Myc (Santa Cruz Biotechnology, sc-42), Anti-Cyclin D1 (Proteintech, 26939-1-AP), Anti-E-cadherin (Proteintech, 20874-1-AP), Anti-N-cadherin

(6) The GOLM1-ACLY pathway regulates macrophage-secreted EFEMP1 via H3K27ac modifications to drive tumor progressionJournal of Advanced ResearchJuly 4, 2025Lan Zhen, Min Min, Xinglin Mo, Guilin Zhao, Huilong Li, Muyi Liu, Luming Wan, Xiaopan Yang, Linfei Huang, Yanhong Zhang, et al.USA), anti-SOX2 (11064-1-AP, Proteintech, USA), anti-NANOG (sc-374001, Santa Cruz, USA), anti-MYC (sc-42, Santa Cruz, USA), anti-GOLM1 (15126-1-AP, Proteintech, USA), anti-EFEMP1 (ab228797, Abcam, UK), anti-GAPDH

(7) The ubiquitin ligase NKLAM promotes apoptosis and suppression of cell growthJournal of Biological ChemistryJune 1, 2025Paul A. Willard, Jacki Kornbluthwere IP’d from lysates using anti-V5 (Invitrogen; Cat#: MA5-15253), or anti-c-Myc (Santa Cruz; Cat#: sc-42) antibodies, respectively, at 1 μg per IP with 10 μl protein G beads (Millipore Sigma; Cat#: GE17–0618–01).

(8) Compartmentalization of heme biosynthetic pathways into yeast mitochondria enhances heme productionNPJ Sci FoodMay 22, 2025Jae Yoon Won, Hyun-Jae Lee, Eun Bi Yoon, Young-Wook Chin, Sun-Ki Kimassays, HEM2 with a C-terminal Myc proto-oncogene protein tag was detected using an anti-Myc antibody (sc-42, 1:1000 dilution), as specified by the manufacturer (Santa Cruz Biotechnology, Inc., Dallas, TX, USA). Analytical

(9) Tripartite motif-containing 27 negatively regulates NF-κB activation in bone remodelingMol MedApril 18, 2025Kabsun Kim, Jung Ha Kim, Inyoung Kim, Semun Seong, Hyun Kook, Jeong-Tae Koh, Nacksung KimSDS-PAGE and Western blotting. Primary antibodies used included TRAF6 (#sc-7221), NFATc1 (#sc-7294), Myc (#sc-42), Ub (#sc-8017, Santa Cruz Biotechnology, Dallas, TX, USA), IκB (#4812), p-IκB (#2859, Cell signaling technology

(10) Functional comparison of human and murine equilibrative nucleobase transporter 1PLOS ONEOctober 3, 2024Chan S. Kim, Aaron L. Sayler, Hannah Dean, Nicholas M. Ruel, James R. Hammondsc-47778, Lot #B0719; Santa Cruz Biotechnology Inc., Texas), mouse monoclonal IgG1 anti-MYC antibody (C-33, sc-42, Lot #3013479; Santa Cruz Biotechnology Inc., Texas), and rabbit polyclonal anti-hENBT1 (HPA030551,

(11) TRPC5 expression promotes the proliferation and invasion of papillary thyroid carcinoma through the HIF-1α/Twist pathwayTranslational OncologyJanuary 1, 2024Jing Yang, Yue Cheng, Yan Nie, Bole Tian, Jing Huang, Rixiang Gong, Zhihui Li, Jingqiang Zhu, Yanping GongFPS conditions. The growth of the tumor was monitored every 7 days with digital calipers. sh-TRPC5 (sc-42,670-V) was purchased from Santa Cruz Biotechnology, Inc. Immunohistochemical staining All the tissue

(12) Histone variant H2B.Z acetylation is necessary for maintenance of Toxoplasma gondii biological fitnessBiochimica et Biophysica Acta (BBA) - Gene Regulatory MechanismsSeptember 1, 2023Laura Vanagas, Daniela Muñoz, Constanza Cristaldi, Agustina Ganuza, Rosario Nájera, Mabel C. Bonardi, Valeria R. Turowski, Fanny Guzman, Bin Deng, Kami Kim, et al.α–rROP18 (rabbit) produced in the laboratory and α-c-Myc (rabbit, abCam ab9106 or mouse, Santa Cruz sc-42), α–AcTubulin (mouse, Millipore MABT868) were incubated for 1 h at room temperature. After several washes

(13) NUDT22 promotes cancer growth through pyrimidine salvageOncogeneApril 1, 2023Walter M, Mayr F, Hanna BMF, Cookson V, Mortusewicz O, Helleday T, Herr P.

(14) Histone variant H2B.Z acetylation is necessary for maintenance of Toxoplasma gondii biological fitnessbioRxivFebruary 28, 2023Laura Vanagas, Daniela Muñoz, Constanza Cristaldi, Agustina Ganuza, Rosario Nájera, Mabel C. Bonardi, Valeria R. Turowski, Fanny Guzman, Bin Deng, Kami Kim, et al.(rabbit), αrROP18 (rabbit) produced in the laboratory and αc-Myc (rabbit, abCam ab9106 or mouse, Santa Cruz sc-42), αAcTubulin (mouse, Millipore MABT868) were incubated for 1 h at room temperature. After several washes

(15) Iron-mediated oxidative stress induces PD-L1 expression via activation of c-Myc in lung adenocarcinomaFrontiers in cell and developmental biologyJanuary 1, 2023Battaglia AM, Sacco A, Aversa I, Santamaria G, Palmieri C, Botta C, De Stefano R, Bitetto M, Petriaggi L, Giorgio E, et al.with primary antibodies against PD-L1 (1:1,000, PA5-28115, ThermoFisher Scientific), c-Myc (1:500, sc-42, Santa Cruz Biotechnology), Nrf2 (1:200, sc-365949, Santa Cruz Biotechnology), NF-κB (1:500, sc-8008,

(16) Overexpressed c-Myc Sensitizes Cells to TH1579, a Mitotic Arrest and Oxidative DNA Damage InducerBiomoleculesNovember 29, 2022Henriksson S, Calderón-Montaño JM, Solvie D, Warpman Berglund U, Helleday T.(Millipore, Burlington, MA, USA; cat# 05-636), mouse anti-c-Myc (Santa Cruz, Dallas, TX, USA; cat# sc-42), rabbit anti-cleaved PARP Asp214 (Cell Signaling, Danvers, MA, USA; cat# 9541), rabbit anti-MTH1 (Novus Biologicals

(17) Mutation of the RelA(p65) Thr505 phosphosite disrupts the DNA replication stress response leading to CHK1 inhibitor resistanceThe Biochemical journalOctober 14, 2022Hunter JE, Campbell AE, Butterworth JA, Sellier H, Hannaway NL, Luli S, Floudas A, Kenneth NS, Moore AJ, Brownridge PJ, et al.(Thermo-scientific, U.K.) were used for detection. Antibodies Antibodies used were c-Rel (sc-71 Santa Cruz), c-Myc (sc-42 Santa Cruz), ATR (sc1887 Santa Cruz), RelA (sc-372 Santa Cruz), RelB (4954 Cell Signaling), p105/p50

(18) A FBXO7/EYA2-SCF(FBXW7) axis promotes AXL-mediated maintenance of mesenchymal and immune evasion phenotypes of cancer cellsMolecular cellMarch 17, 2022Shen JZ, Qiu Z, Wu Q, Zhang G, Harris R, Sun D, Rantala J, Barshop WD, Zhao L, Lv D, et al.anti-human Phosphoserine,Sigma-Aldrich,Cat# P5747; RRID:AB_477376 Mouse anti-human c-MYC,Santa Cruz,Cat# sc-42; RRID:AB_2282408 Rabbit anti-human MCL-1,Cell Signaling,Cat# 4572; RRID:AB_2281980 Mouse anti-Flag

(19) Mesalazine induces apoptosis via mitochondrial pathway in K562 cell lineVet Res ForumMarch 15, 2022Parisa Forsati, Yaghub Pazhang(PBS, BSA, TX-100 and sodium azide) followed by incubation in c-Myc antibody solution (c-Myc anti-body, sc-42; Santa Cruz Biotechnology, Dallas, USA) and diluted by 1/100 in anti-body buffer solution for 2 hr at

(20) Phospholipase Cγ1 represses colorectal cancer growth by inhibiting the Wnt/β-catenin signaling axisBiochemical and biophysical research communicationsNovember 5, 2021Shin KJ, Jang HJ, Lee YJ, Lee YG, Suh PG, Yang YR, Chae YC.

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c-Myc (C-33) Antibody

c-Myc (C-33) Antibody from Santa Cruz Biotechnology, Inc.

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Santa Cruz Biotechnology, Inc.

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c-Myc (C-33) Antibody from Santa Cruz Biotechnology, Inc.

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