BAP1 (C-4) Antibody from Santa Cruz Biotechnology, Inc.

The BAP1 (C-4) Antibody has been shown to work in various applications including Western Blotting, ELISA, Immunofluorescence, Immunohistochemistry, and Immunoprecipitation. For instance, it has been utilized in studies to assess the effects of lurbinectedin on malignant pleural mesothelioma cells and to investigate the role of BAP1 in myeloid leukaemogenesis and neuroblastoma cell apoptosis.

Yes, the BAP1 (C-4) Antibody is reactive with both human and mouse tissues, as well as rat tissues. This broad reactivity makes it suitable for comparative studies across different species, particularly in cancer research where BAP1 mutations are implicated.

Research utilizing the BAP1 (C-4) Antibody has revealed its dual role in cancer. For example, studies have shown that BAP1 can act as a tumor suppressor by regulating apoptosis in neuroblastoma cells, while also being involved in promoting leukaemogenesis when mutated, as seen in the interaction with ASXL1 mutations in myeloid neoplasms.

Yes, several studies have cited the use of the BAP1 (C-4) Antibody. For instance, it was used to demonstrate that BAP1 is phosphorylated at serine 592 in response to DNA damage, which plays a role in the DNA damage response pathway. Additionally, it has been involved in research showing that BAP1 downregulates NRF2 target genes in lung adenocarcinoma, highlighting its importance in tumor biology.