Rat Anti-Mouse CD80/B7-1-PE MBS673446 from MyBioSource.com

Product Specs
ItemRat Anti-Mouse CD80/B7-1-PE
CompanyMyBioSource.com
Price $255.00Supplier Page View Company Product Page
Catalog NumberMBS673446
FormatR - phycoerythrin (R - PE) Conjugate
HostRat
Conjugate/TagR - phycoerythrin (R - PE)
ApplicationsFlow Cytometry; Immunoprecipitation
ClonalityMonoclonal
IsotypeIgG2a kappa
ReactivityMouse
Clone1G10
ImmunogenMouse CD80 (B7-1), Mr 45-47 kDa
CD80 (B7-1) is a type I transmembrane glycoprotein and a member of the immunoglobulin superfamily of cell surface receptors. It is constitutively expressed by dendritic cells, monocytes, and peritoneal macrophages. Expression of CD80 on B cells is upregulated after activation by various means including stimulation by LPS, IL- 4, and surface Ig receptor cross linking with peak expression occurring between 48 and 72 hours postactivation. ^1-4 The interaction of CD80/B7-1 with its ligands, CD28 and CD152/CTLA-4, provides a potent costimulatory signal for T cells activated through the CD3/T cell receptor complex.^5, 6 The monoclonal antibody 1G10 blocks binding of CTLA-4 to CD80, but it does not block stimulation of T cells by natural antigenpresenting cells. ^2, 7
Quantity0.1 mg
Antibody TypeSecondary
TargetCD80/B7-1