CDK9 (C12F7) Rabbit mAb 2316S from Cell Signaling Technology

Product Specs
ItemCDK9 (C12F7) Rabbit mAb
CompanyCell Signaling Technology
Price $339.00 Inquire
Catalog Number2316S
Quantity100 µl
ApplicationsW, IP, IHC-P, IF-IC, FC-FP, C&R, eCLIP
ReactivityH, M, R, Hm, Mk, B, Dg
TargetCdk9
HostRabbit
NCBI Gene AliasesC-2k, CDC2L4, CTK1, PITALRE, TAK
ClonalityMonoclonal
NCBI Full Gene Namecyclin dependent kinase 9
Research AreaCell Cycle / Checkpoint Control
CloneC12F7
Molecular Weight42, 55

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Cell Signaling Technology

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Danvers, Massachusetts 01923

United States

Phone: 877-616-CELL
Phone: 978-867-2388
Fax: 866-432-6112
Fax: 978-867-2488

Company Profile

Website: http://www.cellsignal.com/

Website: Technical Support

(1) Correction of the molecular phenotype of X-linked Dystonia-Parkinsonism reveals a non-canonical function of BRD4Nat CommunMay 5, 2026Simona Capponi, Sandra Ehret, Zeynep Camgöz, Fabian Gather, Christine A. Vaine, Ezgi Özyerli-Göknar, Marie Follo, D. Cristopher Bragg, Tanja Vogel, H. Th. Marc TimmersVinculin (Santa Cruz, cat. no. sc-73614, clone ID 7F9, lot H1721, 1:1000), CDK9 (Cell Signaling, cat. no. 2316, clone ID C12F7, lot 10, 1:1000), pol II Ser2-P (Cell Signaling, cat. no. 31262, clone ID E1Z3G, lot

(2) Discovery of a First-in-Class Murine Double Minute 2-Recruiting Positive Transcription Elongation Factor B PROTAC Degrader With Selective Antitumor ActivityMedComm (2020)April 9, 2026Xian Guan, Long Xie, Hanjun Guo, Lin Ma, Jiawei Zhou, Lisong Luo, Hao Yang, Yuanfang Wu, Jiangyu Liu, Yue Wang, et al.for immunoblot analysis. The following primary antibodies were used: CDK9 (Cell Signaling Technology, 2316), CDK9 (Santa Cruz, sc‐13130), Cyclin T1 (Cell Signaling Technology, 81464), Cyclin T2 (Santa Cruz,

(3) Inhibition of CDK9 sensitizes multidrug resistant ovarian cancer cells to paclitaxelSci RepApril 7, 2026Jinglu Wang, Francis J. Hornicek, Huirong Shi, Wenlong Feng, Zhenfeng Duanincubated with specific primary antibodies at 4 °C overnight: CDK9 (Cell Signaling Technology, Cat.#2316, 1:1000 dilution); RNAPII (Abcam, Cat.#ab817, 1:1000 dilution), S2 RNAPII (Abcam, Cat.#ab5095, 1:1000

(4) Dual Modes of Gene Regulation by CDK12bioRxivFebruary 17, 2026Yubao Wang, Apoorva Baluapuri, Cherubin Manokaran, Jing Ni, Tao Jiang, Roel C. Janssens, Jurgen A. Marteijn, Karen Adelman, Jean Zhao, Thomas M. RobertsCDK8 (D6M3J) Rabbit mAb (Cell Signaling Technology, #17395); CDK9 (C12F7) Rabbit mAb (Cell Signaling Technology, #2316); Anti-CDK19 (Sigma-Aldrich, #HPA007053); JunB Rabbit mAb, clone ARC0268 (ABclonal, #A4848); c-Jun (60A8) Rabbit mAb

(5) Transcription Machinery Anchors ecDNAs to Mitotic Chromosomes for SegregationbioRxivFebruary 5, 2026Yipeng Xie, Jun Yi Stanley Lim, Wenyue Liu, Collin Gilbreath, Xiaohui Sun, Kailiang Qiao, Yoon Jung Kim, Sihan WuTechnology 13546S), anti-c-MYC 1:2,000 (Abcam ab32072), anti-CDK9 1:1,000 (Cell Signaling Technology 2316S), anti-DHFR 1:1,000 (Cell Signaling Technology 43497), anti-Vinculin 1:10,000 (Proteintech 66305–1-Ig),

(6) DualPG‐DTA: A Large Language Model‐Powered Graph Neural Network Framework for Enhanced Drug‐Target Affinity Prediction and Discovery of Novel CDK9 Inhibitors Exhibiting in Vivo Anti‐Leukemia ActivityAdvanced ScienceJanuary 27, 2026Yihao Chen, Jindi Huang, Cong Liu, Shipeng Zhang, Xinze Li, Zhang Zhang, Tie‐Gen Chen, Ling WangAntibodies were purchased from Cell Signaling Technology (CST, Boston, MA, USA) as follows: anti‐CDK9 (#2316), anti‐p‐RNAP II CTD (Ser2) (#13499), GAPDH (#2118), Mcl‐1 (#4572), c‐MYC (# 18583), CyclinT1 (#D1B6G)

(7) Inhibitors supercharge kinase turnover through native proteolytic circuitsNatureJanuary 22, 2026Natalie S. Scholes, Martino Bertoni, Arnau Comajuncosa-Creus, Katharina Kladnik, Xuefei Guo, Fabian Frommelt, Matthias Hinterndorfer, Hlib Razumkov, Polina Prokofeva, Martin P. Schwalm, et al.2731), FIP200 (1:1,000; Cell Signaling Technology, 12436), CDK9 (1:1,000; Cell Signaling Technology, 2316), TMUB1 (1:1,000, Abcam, EPR14066), cCBL (1:1,000; Cell Signaling Technology, 2747), phosphorylated

(8) Disrupting CDK9 activity suppresses triple-negative breast cancer and is enhanced by EGFR InhibitionCell Oncol (Dordr)January 8, 2026Vera E. van der Noord, Ronan P. McLaughlin, Jessica S. Karuntu, Jichao He, A. Mieke Timmermans, Sunita K. C. Basnet, Yi Long, Sarah Al Haj Diab, Solomon Tadesse, Natalie Proost, et al.for western blotting were commercially available, including phospho-CDK9 (T186; CST #2549), CDK9 (CST #2316), phospho-RNAPII Ser2/Ser5 (CST #4735), phospho-RNAPII Ser2 (CST #13499), phospho-RNAPII Ser5 (CST #13523),

(9) Chemically-induced degradation of the endoplasmic-reticulum stress sensor IRE1 by a VHL-recruiting chimeraNat CommunDecember 11, 2025Jin Du, Elisia Villemure, Matthew Johnson, Caleigh Azumaya, Catarina J. Gaspar, Scot Marsters, David Lawrence, Scott Foster, Alexis Rohou, Tommy K. Cheung, et al.(Cell Signaling, #2118), CDK7 Antibody (Cell Signaling, #2090), CDK9 (C12F7) Rabbit mAb (Cell Signaling, #2316), GSK-3α (D80E6) Rabbit mAb (Cell Signaling, #4337), CSF-1R/M-CSF-R Antibody (Cell Signaling, #3152),

(10) Dinaciclib improves treatment response in chemoresistant hepatoblastomaScientific ReportsDecember 5, 2025Brian T. Hickner, Andres F. Espinoza, Rohit K. Srivastava, Roma H. Patel, Priyanka Rao, Nicholas A. O’Brien, Kalyani R. Patel, Andrew A. Badachhape, Abhishek Kona, Dolores H. López-Terrada, et al.at 4 °C overnight on orbital shakers with primary antibodies at 1:1000 dilution for CDK9 (cat. no. 2316 Cell Signaling, Danvers, MA, USA), Phospho-CDK9 (cat. no. 2549 Cell Signaling, Danvers, MA, USA), CDK1

(11) Discovery of dCDK9-202 as a Highly Potent and Selective PROTAC CDK9 Degrader with Strong In Vivo Antitumor ActivityJ Med ChemOctober 23, 2025Lin Ma, Long Xie, Yue Wang, Xian Guan, Ying Zhang, Hanjun Guo, Jiawei Zhou, Jiyang Liu, Xingze Huang, Chunyu He, et al.standard protocol. Various primary antibodies were used to detect CDK9 (Cell Signaling Technology, 2316), CDK9 (Santa Cruz, sc-13130), ACTIN (Proteintech, 66009-1-Ig), GAPDH (Cell Signaling Technology, 2118),

(12) Targeting processive transcription for Myc-driven circuitry in medulloblastomaNeuro-OncologyOctober 1, 2025Lays Martin Sobral, Faye M. Walker, Krishna Madhavan, Elizabeth Janko, Sahiti Donthula, Etienne Danis, Pradeep Bompada, Ilango Balakrishnan, Dong Wang, Angela Pierce, et al.follows, prepared according to manufacturer recommendations: CDK9 (C12F7) Rabbit mAb Cell Signaling #2316, c-Myc (D84C12) Rabbit mAb Cell Signaling #5605, β-Actin (13E5) Rabbit mAb Cell Signaling #4970, Phospho-Rpb1 CTD (Ser2) (E1Z3G) Rabbit mAb

(13) SNORD93 suppresses colorectal cancer progression by inducing G0/G1 arrest and apoptosisTranslational Cancer ResearchSeptember 30, 2025Yingzhi Xu, Mingzhen Cai, Jiaming Li, Huihui Wu, José María Sayagués, Tingjin Zheng, Zhishan ZhangDanvers, MA, USA], cyclin D3 (cat. No. 2936T; CST), cyclin E2 (cat. No. 4132P; CST), CDK9 (cat. No. 2316P; CST), caspase 3 (cat. No. 14220T; CST), caspase 7 (cat. No. 12827T; CST), caspase 8 (cat. No. 4790T;

(14) Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidineMolecular OncologySeptember 16, 2025Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, et al.Co‐immunoprecipitation of CDK9 and mLST8 was performed as previously described [33] using 2 μg of anti‐CDK9 antibody (2316S; Cell Signaling Technologies), 1 mg protein lysate, and protein A agarose beads (Roche Diagnostics).

(15) Cyclin dependent kinase 9 inhibitor induces transcription-replication conflicts and DNA damage accumulation in breast cancerCancer cell internationalJuly 25, 2025Lee M, Lee KH, Min A, Kim SH, Ham S, Hwang HM, Noh Y, Kim YJ, Lee DW, Koh J, et al.and phospho-CHK1 (ser345, 133D3) were purchased from Cell Signaling Technology (Danvers, MA, USA, #2316, #9718, #39224, #9661, #2348). DDX19 was purchased from BETHYL laboratories (Montgomery, TX, USA, #A300-546A). Immunofluorescence assay

(16) CREPT promotes LUAD progression by enhancing the CDK9 and RNAPII assembly to promote ERK-driven gene transcriptionTheranosticsJuly 25, 2025Mengdi Li, Yuting Lin, Jiayu Wang, He Yang, Danhui Ma, Ye Tian, Yi Wang, Liu Yang, Umar Farooq, Yinyin Wang, et al.'blocked with bovine serum albumin. The primary antibodies including anti-CDK9 (RRID: AB_2291505, #2316, CST) and anti-CREPT (3E10, produced by our lab) were used followed by several washes to remove unbound

(17) Differential activity of specific inhibitors of transcription regulating cyclin-dependent kinases in thyroid cancer cellsEndocrine-Related CancerJune 1, 2025Neel Rajan, Tilak Khanal, Amy Adik, Anisley Valenciaga, Akanksha Nigam, Sandya Liyanarachchi, Matthew D. Ringel(1:1000, 13523S, Cell Signaling), CDK7 (MO1) (1:1000, 2916T, Cell Signaling), CDK9 (C12F7 ) (1:1000, 2316T, Cell Signaling), CDK12 (1:1000, 11973S, Cell Signaling), Anti-CDK13 (1:1000, ABE1860, Millipore Sigma),

(18) HIV-1 Nef activates proviral DNA transcription by recruiting Src kinase to phosphorylate host protein Nef-associated factor 1 to compromise its viral restrictive functionJournal of VirologyMay 20, 2025Tian-Jiao Fan, Chengzuo Xie, Lisha Li, Xia Jin, Jie Cui, Jian-Hua WangCell Signaling Technology), anti-myc tag (ab9106; Abcam), anti-Cyclin-dependent protein kinase 9 (anti-CDK9)(2316; Cell Signaling Technology), anti-phosphorylation-CDK9 (Thr186) (2549; Cell Signaling Technology), and

(19) Exploiting the therapeutic vulnerability of IDH-mutant gliomas with zotiraciclibiScienceApril 18, 2025Ying Pang, Qi Li, Zach Sergi, Guangyang Yu, Olga Kim, Peng Lu, Marina Chan, Xueyu Sang, Herui Wang, Alice Ranjan, et al.POLII,Abcam,#ab5095; RRID: AB_304749 p-CDK9,Cell signaling technology (CST),#2549; RRID: AB_2077300 CDK9,CST,#2316; RRID: AB_2291505 cleaved-caspase 3,CST,#9661; RRID: AB_2341188 γ-H2A.X,CST,#9718; RRID: AB_2118009 cleaved-PARP,CST,#5625;

(20) Targeted degradation of CDK9 potently disrupts the MYC-regulated networkCell chemical biologyApril 17, 2025Toure MA, Motoyama K, Xiang Y, Urgiles J, Kabinger F, Koglin AS, Iyer RS, Gagnon K, Kumar A, Ojeda S, et al.(MO1),Cell Signaling Technology,Cat#2916S Rabbit monoclonal anti-CDK9 (C12F7),Cell Signaling Technology,Cat#2316S Rabbit monoclonal anti-CDK10 (D8Z7Z),Cell Signaling Technology,Cat#36106S Ant-mouse IgG HRP-Linked,Cell Signaling Technology

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CDK9 (C12F7) Rabbit mAb

CDK9 (C12F7) Rabbit mAb from Cell Signaling Technology

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Cell Signaling Technology

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CDK9 (C12F7) Rabbit mAb from Cell Signaling Technology

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