Fig 1: ERK1/2 plays a key role in the regulation of colorectal cancer cells. (A and B) Downregulation of ERK1/2 can inhibit (A) the proliferation and (B) invasion and migration abilities of RKO cells. (C) The expression of MAP2K6, c-Myc and PRKX proteins decreased while the expression of FLNB protein increased in RKO cells after downregulation of PEA15. *P<0.05, **P<0.01 and ***P<0.001 compared to controls.
Fig 2: PEA15 promotes the development of colorectal cancer by regulating the MAPK signaling pathway. (A) Gene microarray analysis revealed that these genes were involved in a variety of signaling pathways. (B) The expression of PEA15, PLD1, ERK, MAP2K6 and PRKX proteins decreased and the expression of FLNB protein increased in RKO cells after downregulation of PEA15, while the expression of p38 and JNK proteins had no significant changes. *P<0.05 and **P<0.01 compared to controls.
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