Fig 1: BiP expression correlated with myofiber atrophy. (A) BiP staining of muscle from a patient with IMNM, a patient with DM, and, a patient with ASS showing abnormal positivity in these cells (*). These cells were positive for muscle RING finger protein-1 (MuRF1). Magnification: ×200. (B) Double IF staining demonstrating the staining of BiP and MuRF1 in the same myofibers in a section from a patient with IMNM. Scale bar, 50 µm. (C) Associations between the percentage of positive BiP and sarcoplasmic MuRF1 expression in muscle tissue obtained from patients with IMNM, DM, and ASS. (D) Relationships between the expression levels of BiP and sarcoplasmic muscle atrophy F-box (MAFbx) expression levels in patients with IMNM, DM, and ASS biopsied muscle. (E) Correlations between the expression levels of BiP and variability coefficient in IMNM, DM, and ASS skeletal muscle sections.