MyBioSource.com's TLE3 rabbit pAb is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Western Blot. The TLE3 rabbit pAb Antibody was generated using TLE family member 3, transcriptional corepressor, and TLE3 as the antigen and it reacts with Homo Sapiens, Human, Mouse, and Rat.
Description
This gene encodes a transcriptional co-repressor protein that belongs to the transducin-like enhancer family of proteins. The members of this family function in the Notch signaling pathway that regulates determination of cell fate during development. Expression of this gene has been associated with a favorable outcome to chemotherapy with taxanes for ovarian carcinoma. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Sep 2013]