The Phospho-4E BP1 (Thr46) Rabbit mAb Antibody from MyBioSource.com is a Rabbit Monoclonal antibody. This antibody recognizes Homo Sapiens, Human, Mouse, and Rat antigen. The Phospho-4E BP1 (Thr46) Rabbit mAb Antibody has been shown to work in the following applications: Immunohistochemistry, Immunohistochemistry - fixed, Immunoprecipitation, and Western Blot.
Description
Translation repressor protein 4E-BP1 (also known as PHAS-1) inhibits cap-dependent translation by binding to the translation initiation factor eIF4E. Hyperphosphorylation of 4E-BP1 disrupts this interaction and results in activation of cap-dependent translation. Both the PI3 kinase/Akt pathway and FRAP/mTOR kinase regulate 4E-BP1 activity