The CCM2 Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to CCM2. This antibody recognizes Homo Sapiens, and Human antigen. The CCM2 Antibody has been shown to work in the following applications: Immunohistochemistry.
Description
This gene encodes a scaffold protein that functions in the stress-activated p38 Mitogen-activated protein kinase (MAPK) signaling cascade. The protein interacts with SMAD specific E3 ubiquitin protein ligase 1 (also known as SMURF1) via a phosphotyrosine binding domain to promote RhoA degradation. The protein is required for normal cytoskeletal structure, cell-cell interactions, and lumen formation in endothelial cells. Mutations in this gene result in cerebral cavernous malformations. Multiple transcript variants encoding different isoforms have been found for this gene