The Phospho-DNA PKcs (Ser2056) Rabbit mAb Antibody from MyBioSource.com is a Rabbit Monoclonal antibody to PRKDC, and protein kinase, DNA-activated, catalytic subunit. This antibody recognizes Homo Sapiens, and Human antigen. The Phospho-DNA PKcs (Ser2056) Rabbit mAb Antibody has been shown to work in the following applications: Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunohistochemistry - fixed, and Western Blot.
Description
The PRKDC gene encodes the catalytic subunit of a nuclear DNA-dependent serine/threonine protein kinase (DNA-PK). The second component is the autoimmune antigen Ku (MIM 152690), which is encoded by the G22P1 gene on chromosome 22q. On its own, the catalytic subunit of DNA-PK is inactive and relies on the G22P1 component to direct it to the DNA and trigger its kinase activity; PRKDC must be bound to DNA to express its catalytic properties