Fig 1: Severe SARS-CoV-2 infection leads to interferon-stimulated antiviral proteins. Male 5- to 6-week-old golden Syrian hamsters were infected intratracheally with SARS-CoV-2 isolate USA-WA-1/2020 or mock challenged with vehicle (PBS), and lungs were excised at days 2, 4, and 6 postinfection. Immunoblots and relative protein level (densitometry) against ISG-15, SLAMF9, RSAD2, IRF-3, IRF-3p, IRF-7, IRF-7p, STAT1, STAT1p, STAT3, and STAT3p. Kruskal-Wallis test with Dunn’s multiple-comparison posttest. Asterisks denote the level of significance observed, as follows: *, P ≤ 0.05; **, P ≤ 0.01; ***, P ≤ 0.001; ****, P ≤ 0.0001.