MyBioSource.com's Ctip2 Rabbit mAb is a Rabbit monoclonal antibody. The Ctip2 Rabbit mAb Antibody was generated using BAF chromatin remodeling complex subunit BCL11B, and BCL11B as the antigen. It reacts with Human. This antibody has been shown to work in applications such as: Western Blot.
Description
Key regulator of both differentiation and survival of T-lymphocytes during thymocyte development in mammals. Essential in controlling the responsiveness of hematopoietic stem cells to chemotactic signals by modulating the expression of the receptors CCR7 and CCR9, which direct the movement of progenitor cells from the bone marrow to the thymus (PubMed:27959755). Is a regulator of IL2 promoter and enhances IL2 expression in activated CD4+ T-lymphocytes (PubMed:16809611). Tumor-suppressor that represses transcription through direct, TFCOUP2-independent binding to a GC-rich response element. May also function in the P53-signaling pathway