The PSD-95 Polyclonal Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to DLG4. This antibody recognizes Human, Mouse, and Rat antigen. The PSD-95 Polyclonal Antibody has been shown to work in the following applications: Western Blot.
Description
Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B. Also regulates AMPA-type glutamate receptor (AMPAR) immobilization at postsynaptic density keeping the channels in an activated state in the presence of glutamate and preventing synaptic depression