The HR Polyclonal Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to HR, and HR lysine demethylase and nuclear receptor corepressor. This antibody recognizes Human, Mouse, and Rat antigen. The HR Polyclonal Antibody has been shown to work in the following applications: Western Blot.
Description
This gene encodes a protein that is involved in hair growth. This protein functions as a transcriptional corepressor of multiple nuclear receptors, including thyroid hormone receptor, the retinoic acid receptor-related orphan receptors and the vitamin D receptors, and it interacts with histone deacetylases. The translation of this protein is modulated by a regulatory open reading frame (ORF) that exists upstream of the primary ORF. Mutations in this upstream ORF cause Marie Unna hereditary hypotrichosis (MUHH), an autosomal dominant form of genetic hair loss. Mutations in this gene also cause autosomal recessive congenital alopecia and atrichia with papular lesions, other diseases resulting in hair loss. Two transcript variants encoding different isoforms have been found for this gene