The NDP Rabbit pAb Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to NDP, and norrin cystine knot growth factor NDP. This antibody recognizes Human, and Mouse antigen. The NDP Rabbit pAb Antibody has been shown to work in the following applications: Western Blot.
Description
Activates the canonical Wnt signaling pathway through FZD4 and LRP5 coreceptor. Plays a central role in retinal vascularization by acting as a ligand for FZD4 that signals via stabilizing beta-catenin (CTNNB1) and activating LEF/TCF-mediated transcriptional programs. Acts in concert with TSPAN12 to activate FZD4 independently of the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1). May be involved in a pathway that regulates neural cell differentiation and proliferation. Possible role in neuroectodermal cell-cell interaction