MyBioSource.com's Anti-Mouse IFN gamma SAFIRE is a Rat monoclonal antibody. It reacts with Mouse. This antibody has been shown to work in applications such as: EIA, Immunoassay, ELISA, Flow Cytometry, Functional Assay, Immunofluorescence, and Immunohistochemistry.
Description
The XMG1.2 is a neutralizing antibody that binds with the mouse Interferon-gamma (IFN-gamma) protein, a 15 -17 kDa cytokine with significant antibacterial, antiviral, and antitumoral properties. When secreted by natural killer cells and by natural killer T lymphocytes, it regulates the immune response and supports adaptive immunity when produced by Th1 or CD8+ T lymphocytes. IFN-gamma plays an important role in the activation, the growth, and the differentiation of the macrophages, B and T lymphocytes, and natural killer cells. It interacts synergically with other cytokines, such as TNF-alpha, to inhibit proliferation of normal and transformed cells. IFN- gamma is the primary cytokine that defines Th-1 cells.
The biological activity of IFN-gamma is not affected by glycosylation