The Anti-Hu CD8 APC Antibody from MyBioSource.com is a Mouse Monoclonal antibody. This antibody recognizes Human, and Non-Human Primate antigen. The Anti-Hu CD8 APC Antibody has been shown to work in the following applications: Cell Sorting, Isolation, Flow Cytometry, and Immunofluorescence.
Description
The CD8 T cell coreceptor (monomer approx. 32-34kDa) is expressed as alpha/beta heterodimer on majority of MHC I-restricted conventional T cells and thymocytes and as alpha/alpha homodimer on subsets of memory T cells, intraepithelial lymphocytes, NK cells and dendritic cells. Regulation of CD8 beta level on T cell surface seems to be an important mechanism to control their effector Functional Application (FUNC)tion. Assembly of CD8 alpha-beta but not alpha-alpha dimers is connected with formation or localization to the lipid rafts. Recruiting triggered TCR complexes to these membrane microdomains as well as affinity of TCR to MHC I is modulated by CD8, thereby affecting the Functional Application (FUNC)tional diversity of the TCR signaling