The PHOX2B Polyclonal Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to PHOX2B. This antibody recognizes Human, Mouse, and Rat antigen. The PHOX2B Polyclonal Antibody has been shown to work in the following applications: Immunohistochemistry, and Western Blot.
Description
The DNA-associated protein encoded by this gene is a member of the paired family of homeobox proteins localized to the nucleus. The protein functions as a transcription factor involved in the development of several major noradrenergic neuron populations and the determination of neurotransmitter phenotype. The gene product is linked to enhancement of second messenger-mediated activation of the dopamine beta-hydroylase, c-fos promoters and several enhancers, including cyclic amp-response element and serum-response element. Expansion of a 20 amino acid polyalanine tract in this protein by 5-13 aa has been associated with congenital central hypoventilation syndrome