IRF5 Antibody NB100-1092 from Novus Biologicals, a Bio-Techne Brand

Product Specs
ItemIRF5 Antibody
CompanyNovus Biologicals, a Bio-Techne Brand
Price $399.00Supplier Page View Company Product Page
Catalog NumberNB100-1092
NCBI Gene AliasesSLEB10
ImmunogenPeptide with sequence C-QGPWPMHPAGMQ corresponding to C-Terminus according to NP_002191.1, NP_116032.1, NP_001092097.1, NP_001092099.1
Concentration0.5 mg/ml
TargetIRF5
FormatTris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA
ReactivityHuman,Mouse
ApplicationsChemotaxis,Flow Cytometry,Western Blot,Peptide ELISA,Chromatin Immunoprecipitation (ChIP),Knockdown Validated
Conjugate/TagUnconjugated
HostGoat
Quantity0.1 mg
NCBI Full Gene Nameinterferon regulatory factor 5
ClonalityPolyclonal
PurityImmunogen affinity purified
Molecular Weight56 kDa
Research AreaApoptosis, Death Receptor Signaling Pathway
IsotypeIgG
Antibody TypePrimary Antibodies
StorageStore at -20C. Avoid freeze-thaw cycles

Specifications/Features

Available conjugates: Available conjugates: Unconjugated

Specificity: This antibody is expected to recognize all four reported isoforms (NP_002191.1; NP_116032.1; NP_001092097.1; NP_001092099.1). Reported variants NP_001092100.1, NP_001092101.1, NP_001092098.1, NP_001092097.1 represent identical protein: Reported variants NP_116032.1, NP_001092100.1 represent identical protein

Sizes Available: 0.1 mg

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Novus Biologicals, a Bio-Techne Brand

United States: 10771 E Easter Ave

Centennial, Colorado 80112

United States

Phone:
303-730-1950
888-506-6887

Email: novus@novusbio.com

Company Profile

Website: https://www.novusbio.com

(1) Specific detection of interferon regulatory factor 5 (IRF5): A case of antibody inequalityScientific reportsAugust 2, 2016Li D, De S, Li D, Song S, Matta B, Barnes BJ.expression in all three cell lines indicating lack of specificity. Antibodies #124792 (Abcam; ab124792) and NB100-1092 (Novus Biologicals) detected a similar large, single band in THP1 cells but were unable to detect IRF5

(2) MyD88-dependent signaling influences fibrosis and alternative macrophage activation during Staphylococcus aureus biofilm infectionPloS oneJanuary 1, 2012Hanke ML, Angle A, Kielian T.

(3) Loss of interferon regulatory factor 5 (IRF5) expression in human ductal carcinoma correlates with disease stage and contributes to metastasisBreast cancer research : BCRJanuary 1, 2011Bi X, Hameed M, Mirani N, Pimenta EM, Anari J, Barnes BJ.

(4) IRF5 is required for late-phase TNF secretion by human dendritic cellsBloodJune 3, 2010Krausgruber T, Saliba D, Ryzhakov G, Lanfrancotti A, Blazek K, Udalova IA.

(5) IRF-5 is a mediator of the death receptor-induced apoptotic signaling pathwayThe Journal of biological chemistryJanuary 30, 2009Hu G, Barnes BJ.

(6) Methamphetamine enhances Hepatitis C virus replication in human hepatocytesJournal of viral hepatitisApril 1, 2008Ye L, Peng JS, Wang X, Wang YJ, Luo GX, Ho WZ.

(7) Three functional variants of IFN regulatory factor 5 (IRF5) define risk and protective haplotypes for human lupusProceedings of the National Academy of Sciences of the United States of AmericaApril 17, 2007Graham RR, Kyogoku C, Sigurdsson S, Vlasova IA, Davies LR, Baechler EC, Plenge RM, Koeuth T, Ortmann WA, Hom G, et al.

(8) Interferon regulatory factor 5 represses expression of the Epstein-Barr virus oncoprotein LMP1: braking of the IRF7/LMP1 regulatory circuitJournal of virologySeptember 1, 2005Ning S, Huye LE, Pagano JS.

(9) Virus-specific activation of a novel interferon regulatory factor, IRF-5, results in the induction of distinct interferon alpha genesThe Journal of biological chemistryJune 29, 2001Barnes BJ, Moore PA, Pitha PM.