Description
Product Characteristics:
Synonyms: Protein CBFA2T1:Cyclin-D-related protein:Eight twenty one protein:Protein ETO:Protein MTG8:Zinc finger MYND domain-containing protein 2:RUNX1T1:AML1T1:CBFA2T1:CDR:ETO:MTG8:ZMYND2
Target Information: This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(8\,21)(q22\,q22) translocation is one of the most frequent karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2010]