Fig 1: β2‐AR expression on CCR2+MHCIIhigh MoMFs. (A) UMAP of cluster annotations. (B) UMAP plots of different markers of cell types in annotated myeloid cells. (C) UMAP of myeloid cell annotations. (D) Violin plot of Adrb2 expression on CCR2+MHCIIhigh macrophages, monocytes, and dendritic cells. (E) Violin plot of Adrb2 expression on CCR2+MHCIIhigh macrophages in the control and myocarditis groups. (F) Flow cytometry analysis of β2‐adrenergic receptor expression on CD45+CD64+F4/80+CCR2+MHCIIhigh MoMFs from myocarditis mice 1 week and 2 weeks after CVB3 infection and from control mice. (G) Statistical histogram of the flow cytometry results (n = 6/group). The data are presented as means ± SEMs. *p< 0.05, **p< 0.01, ***p< 0.001, ****p< 0.0001. β2‐AR, adrenergic receptor; CCR2, C‐C chemokine receptor type 2; MHCII, major histocompatibility complex class II; MoMFs, monocyte‐derived macrophages; UMAP, uniform manifold approximation and projection; SEM, standard error and mean.