The SUN2 Polyclonal Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to SUN2. This antibody recognizes Human, Mouse, and Rat antigen. The SUN2 Polyclonal Antibody has been shown to work in the following applications: Immunofluorescence.
Description
SUN1 (MIM 607723) and SUN2 are inner nuclear membrane (INM) proteins that play a major role in nuclear-cytoplasmic connection by formation of a 'bridge' across the nuclear envelope, known as the LINC complex, via interaction with the conserved luminal KASH domain of nesprins (e.g., SYNE1; MIM 608441) located in the outer nuclear membrane (ONM). The LINC complex provides a direct connection between the nuclear lamina and the cytoskeleton, which contributes to nuclear positioning and cellular rigidity (summary by Haque et al., 2010 [PubMed 19933576])