The Rabbit Anti-PI3 kinase p85 alpha + gamma Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to PIK3R1. This antibody recognizes Human, Mouse, and Rat antigen. The Rabbit Anti-PI3 kinase p85 alpha + gamma Antibody has been shown to work in the following applications: Immunohistochemistry, Immunohistochemistry - fixed, and Western Blot.
Description
Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p11 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling