The Phospho-Histone H3 (Thr3) Rabbit pAb Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to H3 clustered histone 1, H3 clustered histone 6, H3C1, and H3C6. This antibody recognizes Human antigen. The Phospho-Histone H3 (Thr3) Rabbit pAb Antibody has been shown to work in the following applications: Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, and Western Blot.
Description
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.MiscellaneousThis histone is only present in mammals and is enriched in acetylation of Lys-15 and dimethylation of Lys-10 (H3K9me2). CautionThe original paper reporting lysine deamination at Lys-5 by LOXL2 has been retracted due to inappropriate manipulation of figure data (PubMed: 22483618, PubMed: 27392148). However, this modification was confirmed in a subsequent publication (PubMed: 27735137)