The STIP1 Antibody from MyBioSource.com is a Rabbit Monoclonal antibody to STIP1. This antibody recognizes Human, Mouse, and Rat antigen. The STIP1 Antibody has been shown to work in the following applications: Flow Cytometry, Immunocytochemistry, Immunohistochemistry, Immunoprecipitation, and Western Blot.
Description
Stress-induced-phosphoprotein 1 (STI1) functions as a co-chaperone for HSP70 and HSP90 during heat shock response. STI1 exists as either a monomer or a dimer, and this conformational flexibility facilitates its function in organizing HSP70/HSP90. HSP90 acts as an ATPase, and requires the recruitment of client proteins and proper conformation to function. STI1 acts as a "scaffold" for client protein recruitment to the relaxed, ADP-bound conformation of HSP90, thus suppressing ATP turnover during the loading phase and allowing proper function