MyBioSource.com's CD68 Mouse mAb is a Mouse monoclonal antibody. The CD68 Mouse mAb Antibody was generated using CD68 as the antigen. It reacts with Human, Mouse, and Rat. This antibody has been shown to work in applications such as: Immunohistochemistry.
Description
The CD68 antigen is a 37kD transmembrane protein that is post-translationally glycosylated to give a protein of 87-115kD. CD68 is specifically expressed by tissue macrophages, Langerhans cells and at low levels by dendritic cells. It could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. It binds to tissue- and organ-specific lectins or selectins, allowing homing of macrophage subsets to particular sites. Rapid recirculation of CD68 from endosomes and lysosomes to the plasma membrane may allow macrophages to crawl over selectin bearing substrates or other cells