MyBioSource.com's Anti-TMS1/ASC/Pycard Antibody is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: EIA, Immunoassay, Cell Sorting, Isolation, ELISA, Flow Cytometry, Immunofluorescence, Immunohistochemistry, Immunohistochemistry - fixed, and Western Blot. The Anti-TMS1/ASC/Pycard Antibody was generated using PYCARD as the antigen and it reacts with Mouse, and Rat.
Description
PYCARD, often referred to as ASC (Apoptosis-associated speck-like protein containing a CARD), is a protein that in humans is encoded by the PYCARD gene. This gene encodes an adaptor protein that is composed of two protein-protein interaction domains: a N-terminal PYRIN-PAAD-DAPIN domain (PYD) and a C-terminal caspase-recruitment domain (CARD). The PYD and CARD domains are members of the six-helix bundle death domain-fold superfamily that mediates assembly of large signaling complexes in the inflammatory and apoptotic signaling pathways via the activation of caspase. In normal cells, this protein is localized to the cytoplasm; however, in cells undergoing apoptosis, it forms ball-like aggregates near the nuclear periphery. Two transcript variants encoding different isoforms have been found for this gene