The Anti-SIT PE Antibody from MyBioSource.com is a Mouse Monoclonal antibody to SIT1. This antibody recognizes Human antigen. The Anti-SIT PE Antibody has been shown to work in the following applications: Flow Cytometry.
Description
SIT (SHP2-interacting transmembrane adaptor protein) is expressed exclusively in lymphoid organs and acts either as a positive or as a negative regulatory element in T cell activation and in T cell development. Binding to Grb2 plays a pivotal role in signal transduction. Hubener et al. (2001) determined that the SIT gene contains 5 exons and spans 1.8 kb of genomic DNA. The SIT promoter demonstrated strong transcriptional activity and potential binding sites for both ubiquitous and lymphoid-specific transcription factors