The CCL22 Rabbit Polyclonal Antibody from Bioassay Technology Laboratory is a Rabbit Polyclonal antibody. This antibody recognizes Human, Mouse, and Rat antigen. The CCL22 Rabbit Polyclonal Antibody has been shown to work in the following applications: EIA, Immunoassay, ELISA, and Western Blot.
Description
May play a role in the trafficking of activated/effector T-lymphocytes to inflammatory sites and other aspects of activated T-lymphocyte physiology. Chemotactic for monocytes: dendritic cells and natural killer cells. Mild chemoattractant for primary activated T-lymphocytes and a potent chemoattractant for chronically activated T-lymphocytes but has no chemoattractant activity for neutrophils: eosinophils: and resting T-lymphocytes. Binds to CCR4. Processed forms MDC(3-69): MDC(5-69) and MDC(7-69) seem not be active.:online information:CCL22 entry:PTM:The N-terminal processed forms MDC(3-69): MDC(5-69) and MDC(7-69) are produced by proteolytic cleavage after secretion from monocyte derived dendrocytes.:Belongs to the intercrine beta (chemokine CC) family.:tissue specificity:Highly expressed in macrophage and in monocyte-derived dendritic cells: and thymus. Also found in lymph node: appendix: activated monocytes: resting and activated macrophages. Lower expression in lung and spleen. Very weak expression in small intestine. In lymph node expressed in a mature subset of Langerhans' cells (CD1a+ and CD83+). Expressed in Langerhans' cell histiocytosis but not in dermatopathic lymphadenopathy. Expressed in atopic dermatitis: allergic contact dermatitis skin: and psoriasis: in both the eptdermis and dermis.: