Bioassay Technology Laboratory's KOR-1(Phospho Ser369) Polyclonal Antibody is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: EIA, Immunoassay, ELISA, Immunohistochemistry, Immunohistochemistry - fixed, and Western Blot.
Description
Endogenous opioid peptides and opiates: like morphine: transmit their pharmacological effects through membrane bound opioid receptors. Pharmacological studies and molecular cloning have led to the identification of three different types of opioid receptor: mu-type: delta-type and kappa-type: also designated MOR-1: DOR-1 and KOR-1: respectively. MOR-1 is a receptor for beta-endorphin: DOR-1 is a receptor for enkephalins: and KOR-1 is a receptor for dynorphins.The three opioid receptor types are highly homologous and belong to the superfamily of G-protein-coupled receptors. Opioid receptors have been shown to modulate a range of brain functions: including instinctive behavior and emotions. This regulation is thought to involve the inhibition of neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance