MyBioSource.com's Anti-SS18 Antibody, Rabbit Polyclonal is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Immunocytochemistry, and Immunofluorescence.
Description
SYT (SYnovial sarcoma Translocated gene or SS18) was discovered as part of a nuclear chimeric protein coded by a t(X;18) (p11.2;q11.2) translocation found in many synovial sarcomas. This translocation fuses the SYT gene on chromosome 18 with either the SSX1, SSX2, or SSX4 genes on the X chromosome. The SYT/SSX fusion proteins localize to the nucleus and function as potential transcriptional co-activators and effectors of cell proliferation. Consequently, native SYT, though devoid of a consensus nuclear localization signal, has also been considered to be a nuclear proto-oncogene. SYT is highly conserved among species. Alternative splicing produces at least four isoforms of SYT, and the most prominent of these are the long (SYT/L; 56 kD) and short (SYT/S; 50.5 kD) isoforms, which differ by inclusion of exon 8 in SYT/L