SIRT3 (F-10) Antibody sc-365175 from Santa Cruz Biotechnology, Inc.

Product Specs
ItemSIRT3 (F-10) Antibody
CompanySanta Cruz Biotechnology, Inc.
Price $316.00Supplier Page View Company Product Page
Catalog Numbersc-365175
Quantity200 µg/ml
ApplicationsWB, IP, IF, ELISA
Reactivitymouse, rat, human
Conjugate/TagUnconjugated
TargetSIRT3
FormatPurified
Hostmouse
Antibody TypePrimary Antibodies
CloneF-10
IsotypeIgG2b
NCBI Gene Aliases2310003L23Rik, Sir2l3, SIR2L3
ClonalityMonoclonal
NCBI Full Gene Namesirtuin 3

Questions and Answers

Can this antibody be used to study the role of SIRT3 in neurodegenerative diseases?

Yes, the SIRT3 (F-10) Antibody has been utilized in studies examining its role in neurodegenerative diseases. For instance, research has shown that SIRT3 is involved in the miR-195-SIRT3 axis, which regulates apoptosis in hippocampal cells, suggesting its significance in neurodegenerative processes ().

Is this antibody effective for Western blotting applications?

The SIRT3 (F-10) Antibody has been successfully used in Western blotting, as evidenced by its application in various studies, including those investigating the effects of gastrodin on human periodontal ligament stem cells and its role in inflammation and oxidative stress ().

What species can this antibody react with, and has it been cited in relevant studies?

The SIRT3 (F-10) Antibody is reactive with mouse, human, and rat species. It has been cited in over 50 scientific articles, indicating its widespread use and relevance in various research contexts, including cancer and metabolic studies (, ).

How has this antibody been utilized in cancer research?

The SIRT3 (F-10) Antibody has been employed in studies investigating its effects on cancer cell lines, such as MDA-MB-231, where it was shown to diminish tumorigenic properties under hyperoxic conditions, highlighting its potential role in cancer biology ().

Santa Cruz Biotechnology, Inc.

10410 Finnell Street

Dallas, Texas 75220

United States

Phone: 1-800-457-3801
831-457-3801

Company Profile

Website: http://www.scbt.com/

(1) Dapagliflozin Protects Cardiomyocytes against Doxorubicin-Induced Toxicity by Modulating Sirtuin 1/Sirtuin 3 and Ferroptosis PathwayACS Pharmacology & Translational ScienceMay 8, 2026Hnin Ei Ei Khine, Supachoke Mangmool, Warisara Parichatikanondprimary antibodies targeting SIRT1 (Santa Cruz Biotechnology, Santa Cruz, CA, USA; sc-74465), SIRT3 (sc-365175), ACSL4 (sc-365230), GPX4 (sc-166570), DNM1 (sc-12724), OPA1 (sc-393296), PGC1α (sc-518025), BCL2 (Cell Signaling Technology

(2) Endothelial FUNDC1 regulates metabolic reprogramming and the obesity-diabetes transition through the SIRT3/GATA2/endothelin-1 axisNature CommunicationsJanuary 16, 2026Jian Li, Dayong Li, Fujie Zhao, Yadong Wang, Hongmin Yao, Yin Wu, Junqing An, Zhixue Liu, Ye Ding, Ming-Hui Zoucells with primary antibodies against FUNDC1 (Biorbyt, orb156964), SIRT3 (Santa Cruz Biotechnology, sc-365175), GATA2 (Proteintech, 11103-1-AP), or isotype control at 4 °C overnight, and followed by incubation

(3) Delactylase effects of SIRT3 on a positive feedback loop involving the RUNX1-glycolysis-histone lactylation in diabetic kidney diseaseInternational Journal of Biological SciencesJanuary 15, 2026Siman Shen, Chen Ying, Xinglin Fu, Xiaobian Zeng, Xiuli Guo, Han Wu, Liangqing Zhang, Li Xucell lysate was subjected to immunoprecipitation. The extract was first incubated with anti-SIRT3 (sc-365175, Santa Cruz Biotechnology) for 24 hours at 4 °C. A mixture was supplemented with Protein A/G Agarose

(4) SIRT3 attenuates AGEs-induced senescence in human granulosa cells through enhancing mitophagyCell Biology and ToxicologyJanuary 13, 2026Shuhang Li, Mingge Tang, Sihui Zhu, Zhiguo Zhang, Yunxia Cao, Rufeng Xue(14,220, CST, USA), anti-Cleaved Caspase 3 (9664, CST, USA), anti-Bax (5023, CST, USA), anti-SIRT3 (sc-365175, Santa Cruz, USA), and anti-Parkin (1:1000, 14,060–1-AP, Proteintech, China), and 1:2000 for anti-Tom20

(5) Supplementation With Curcumin Exhibits Nephroprotective Effects in Cisplatin‐Induced Acute Kidney InjuryFood Science & NutritionDecember 1, 2025Mingkang Zhang, Yazhi Wang, Xiujuan Wang, Yan Zhou, Yanrong Ma, Xin'an WuAb184247) anti‐mitofusin1 (Abcom, Ab126575), anti‐mitofusin2 (Abcom, Ab124773), anti‐Sirt3 (Santa Cruz Bio, sc365175), anti‐PGC‐1α (Santa Cruz Bio, sc518025), anti‐AMPKα (Santa Cruz Bio, sc74461), anti‐p‐AMPKα (Cell signaling technology

(6) Depression like-behavior and memory loss induced by methylglyoxal is associated with tryptophan depletion and oxidative stress: a new in vivo model of neurodegenerationBiological researchNovember 21, 2024Md Samsuzzaman, Hong SM, Lee JH, Park H, Chang KA, Kim HB, Park MG, Eo H, Oh MS, Kim SY.type information regulation 2 homologue (Sirt)-1 (cat. sc135792), Sirt-2 (cat. sc28298), Sirt-3 (cat. sc365175), Sirt-4 (cat. sc135797), Sirt-5 (cat. sc271635), and Sirt-7 (cat. sc365344) were purchased from Santa Cruz Biotechnology

(7) N-Acetylneuraminic acid triggers endothelial pyroptosis and promotes atherosclerosis progression via GLS2-mediated glutaminolysis pathwayCell Death DiscoveryNovember 13, 2024Zhaohong Liu, Peng Xiang, Shengmei Zeng, Ping Weng, Yilin Wen, Wanping Zhang, Hui Hu, Dezhang Zhao, Limei Ma, Chao YuFOXO3a (Proteintech, 66428-1-Ig, diluted 1:1000), mouse Monoclonal Antibody against SIRT3 (Santa Cruz, sc-365175, diluted 1:1000). Horseradish peroxidase-conjugated goat anti-rabbit IgG (Beyotime, A0208, diluted 1:8000)

(8) Mitochondrial protein deacetylation by SIRT3 in osteoclasts promotes bone resorption with aging in female miceMolecular metabolismOctober 1, 2024Richardson KK, Adam GO, Ling W, Warren A, Marques-Carvalho A, Thostenson JD, Krager K, Aykin-Burns N, Byrum SD, Almeida M, et al.Western blotting as described above. Mouse monoclonal antibodies against SIRT3 (1:2000, Santa Cruz Biotechnology, sc-365175) were used to detect SIRT3 proteins. 4.17 ATPIF1 K49R mutant ATPIF1 mutant constructs with lysine

(9) LINC00887 promotes GCN5-dependent H3K27cr level and CRC metastasis via recruitment of YEATS2 and enhancing ETS1 expressionCell Death & DiseaseSeptember 30, 2024Meijian Liao, Wendan Zheng, Yifan Wang, Mengting Li, Xiaolin Sun, Nan Liu, Jia Yao, Fuxing Dong, Qingling Wang, Yu Ma, et al.No. A19607), anti-ETS1 (1:1,000, Beyotime, Cat. No. AF6812), anti-SIRT3 (1:200; Santa Cruz, Cat. No. SC-365175), anti-GCN5 (1:1,000, Affinity, Cat. No. DF3383), anti-H3K27cr (1:1,000, PTM BIO, Cat. No. PTM-545PM),

(10) SIRT3 and RORα are two prospective targets against mitophagy during simulated ischemia/reperfusion injury in H9c2 cellsHeliyonMay 30, 2024Jinjing Wu, Yanli Yang, Duomao Lin, Zhaoqi Wang, Jun MaAntibody,Company,Catalog No.,Dilution SIRT3,Santa Cruz,sc-365175,1:100 Cleaved caspase-3,Wanleibio,WL01992,1:500 Bax,Wanleibio,WL01637,1:500 Bcl-2,Wanleibio,WL01556,1:1000 CypD,ABclonal,A3208,1:1000 VDAC1,Wanleibio,WL02790,1:500 Parkin,Wanleibio,WL02512,1:500 Beclin1,Wanleibio,WL02508,1:500 NIX,Affinit,DF8163,1:500 BNIP3,Wanleibio,WL01139,1:500 LC3

(11) Effect of Gracilaria vermiculophylla Macroalga on Non-Alcoholic Fatty Liver Disease in Obese RatsAntioxidants (Basel)March 18, 2024Maitane González-Arceo, Leixuri Aguirre, María Teresa Macarulla, Clàudia Gil-Pitarch, María Luz Martínez-Chantar, María P. Portillo, Saioa Gómez-ZoritaP62 (1:1000, Abcam, Cambridge, UK, ab56416), SIRT3 (1:500, Santa Cruz Biotechnology Dallas, TX, USA, sc-365175), PGC1α (1:1000, Abcam, Cambridge, UK, ab54481) and α-tubulin (1:1000, Cell Signaling Technology, Danvers,

(12) Baicalein attenuates bleomycin-induced lung fibroblast senescence and lung fibrosis through restoration of Sirt3 expressionPharm BiolDecember 1, 2023Ji-Hong Y, Yu M, Ling-Hong Y, Jing-Jing G, Ling-Li X, Lv W, Yong-Mei J.temperature, the membranes were incubated with BSA-diluted primary antibodies against Sirt3 (1:1000; cat. no. sc-365175; Santa Cruz Biotechnology, Inc., Dallas, TX), p16 (1:1000, cat. no. sc-56330; Santa Cruz Biotechnology, Inc

(13) L-citrulline attenuates lipopolysaccharide-induced inflammatory lung injury in neonatal ratsPediatric researchNovember 1, 2023Ivanovski N, Wang H, Tran H, Ivanovska J, Pan J, Miraglia E, Leung S, Posiewko M, Li D, Mohammadi A, et al.

(14) Nicotinamide Riboside and Phycocyanin Oligopeptides Affect Stress Susceptibility in Chronic Corticosterone-Exposed RatsAntioxidants (Basel, Switzerland)October 12, 2023Orhan C, Sahin E, Tuzcu M, Sahin N, Celik A, Ojalvo SP, Sylla S, Komorowski JR, Sahin K.1:1000 (IL-6 (sc-57315), TNF-α (sc-52746), IL-1β (sc-515598), TRF2 (sc-47693), Tin2 (sc-73177), SIRT3 (sc-365175), NAMPT (sc-393444) (Santa Cruz Biotechnology, Heidelberg, Germany), IL-8 (NBP2-16958), POTlb (NBP2-50255)

(15) Elucidation of novel TRAP1-Selective inhibitors that regulate mitochondrial processesEuropean journal of medicinal chemistryOctober 5, 2023Merfeld T, Peng S, Keegan BM, Crowley VM, Brackett CM, Gutierrez A, McCann NR, Reynolds TS, Rhodes MC, Byrd KM, et al.

(16) DMT1 differentially regulates mitochondrial complex activities to reduce glutathione loss and mitigate ferroptosisFree radical biology & medicineOctober 1, 2023Tan Q, Zhang X, Li S, Liu W, Yan J, Wang S, Cui F, Li D, Li J.

(17) Acetylation of aldehyde dehydrogenase ALDH1L2 regulates cellular redox balance and the chemosensitivity of colorectal cancer to 5-fluorouracilThe Journal of biological chemistrySeptember 1, 2023Li C, Teng P, Sun S, Cui K, Yao S, Fei B, Ling F, Huang Z.acetylation (Cell Signaling Technology, 9441S, 1:1000), Flag (MBL, M185–3, 1:5000), SIRT3 (Santa cruz, sc-365175, 1:1000), HA (Proteintech, 51064-2-AP, 1:5000), His-Tag (Abmart, 2A8, 1:1000) qRT-PCR assay Total

(18) Sialic acids promote macrophage M1 polarization and atherosclerosis by upregulating ROS and autophagy blockageInternational immunopharmacologyJuly 1, 2023Hu X, Li Y, Chen Q, Wang T, Ma L, Zhang W, Yu R, Zhang J, Wan J, Yu C, et al.

(19) Eplerenone reduces renal ischaemia/reperfusion injury by modulating Klotho, NF-κB and SIRT1/SIRT3/PGC-1α signalling pathwaysThe Journal of pharmacy and pharmacologyJune 5, 2023Barati A, Rahbar Saadat Y, Meybodi SM, Nouraei S, Moradi K, Kamrani Moghaddam F, Malekinejad Z, Hosseiniyan Khatibi SM, Zununi Vahed S, Bagheri Y.

(20) Polystyrene Microplastics Induce Oxidative Stress in Mouse Hepatocytes in Relation to Their SizeInternational journal of molecular sciencesApril 17, 2023Zou H, Qu H, Bian Y, Sun J, Wang T, Ma Y, Yuan Y, Gu J, Bian J, Liu Z.

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SIRT3 (F-10) Antibody

SIRT3 (F-10) Antibody from Santa Cruz Biotechnology, Inc.

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Santa Cruz Biotechnology, Inc.

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SIRT3 (F-10) Antibody from Santa Cruz Biotechnology, Inc.

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