WAPL (A-7) Antibody sc-365189 from Santa Cruz Biotechnology, Inc.

Product Specs
ItemWAPL (A-7) Antibody
CompanySanta Cruz Biotechnology, Inc.
Price $316.00Supplier Page View Company Product Page
Catalog Numbersc-365189
Quantity200 µg/ml
ApplicationsWB, IP, IF, ELISA
Conjugate/TagUnconjugated
Reactivityhuman
TargetWAPL
FormatPurified
CloneA-7
Hostmouse
Antibody TypePrimary Antibodies
IsotypeIgG1
NCBI Gene AliasesFOE, KIAA0261, WAPAL
ClonalityMonoclonal
NCBI Full Gene NameWAPL cohesin release factor

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Santa Cruz Biotechnology, Inc.

10410 Finnell Street

Dallas, Texas 75220

United States

Phone: 1-800-457-3801
831-457-3801

Company Profile

Website: http://www.scbt.com/

(1) K29-Linked Ubiquitination of Transcription Regulators Controls Cell Proliferation in the Unfolded Protein ResponseAdvanced science (Weinheim, Baden-Wurttemberg, Germany)November 1, 2025Zhang Q, Teng X, Dai Y, Wu Y, Hou H, Li J.(1:200, Santa Cruz, sc‐8017), anti‐PDS5A (1:2000, Invitrogen, YB3837049), anti‐WAPL (1:200, Santa Cruz, sc‐365189), anti‐STAG2 (1:200, Santa Cruz, sc‐81852), anti‐RAD21 (1:200, Santa Cruz, sc‐166973), anti‐MYC tag

(2) Characterization of induced cohesin loop extrusion trajectories in living cellsNature GeneticsNovember 1, 2025Ruiqi Han, Yike Huang, Michelle J. Robers, Mikhail Magnitov, Iwan Vaandrager, Amin Allahyar, Marjon J. A. M. Verstegen, Kexin Zhang, Elzo de Wit, Wouter de Laat, et al.Active motif), anti-H3K27ac (39133, Active motif), anti-V5 (R960-25, Thermo Fisher Scientific), anti-WAPL (sc-365189, Santa Cruz) and anti-PDS5A (A300-089A, Bethyl). Plasmid construction The plasmids expressing TetR–FLAG–MAU2

(3) Homologous recombination promotes non-immunogenic mitotic cell death upon DNA damageNat Cell BiolJanuary 13, 2025Radoslaw Szmyd, Sienna Casolin, Lucy French, Anna G. Manjón, Melanie Walter, Léa Cavalli, Christopher B. Nelson, Scott G. Page, Andrew Dhawan, Eric Hau, et al.NBP2-22360, 1:1,000), vinculin (hVIN-1, Sigma-Aldrich, V9131, 1:10,000) and WAPL (A-7, Santa Cruz, sc-365189, 1:1,000). The secondary antibodies include horseradish peroxidase conjugated goat anti-mouse (Dako,

(4) Cohesin-mediated DNA loop extrusion resolves sister chromatids in G2 phaseThe EMBO journalAugust 15, 2023Batty P, Langer CC, Takács Z, Tang W, Blaukopf C, Peters JM, Gerlich DW.previously published in (Tedeschi et al, 2013) or a mouse monoclonal antibody (Santa‐Cruz Biotechnology, sc‐365189, 1:1,000). GAPDH was detected using a rabbit polyclonal antibody (Abcam, ab9485, 1:2,500). Vinculin

(5) Structural basis of centromeric cohesion protectionNature structural & molecular biologyJune 1, 2023García-Nieto A, Patel A, Li Y, Oldenkamp R, Feletto L, Graham JJ, Willems L, Muir KW, Panne D, Rowland BD.(A300-158a, Bethyl Laboratories), SMC1 (A300-055A, Bethyl Laboratories), SCC1 (05-908, Millipore), WAPL (A-7, sc-365189, Santa Cruz), Sororin (ab192237, Abcam), HSP90 (sc-13119(F-8), Santa Cruz) and α-tubulin (T5168, Sigma Aldrich

(6) ATM signaling modulates cohesin behavior in meiotic prophase and proliferating cellsNature structural & molecular biologyApril 1, 2023Yu Z, Kim HJ, Dernburg AF.Thermo Fisher R960-25)117, rabbit anti-V5 (1:250, Millipore Sigma V8137)117, mouse anti-WAPL (1:500, Santa Cruz sc-365189), rabbit anti-γH2A.X antibody (1:500, Cell Signaling, cat. no. 2577), mouse anti-ATM antibody (1:500,

(7) The cohesin acetylation cycle controls chromatin loop length through a PDS5A brake mechanismNature structural & molecular biologyJune 1, 2022van Ruiten MS, van Gent D, Sedeño Cacciatore Á, Fauster A, Willems L, Hekkelman ML, Hoekman L, Altelaar M, Haarhuis JHI, Brummelkamp TR, et al.no. WH0055869M1, 1:1,000), AcSMC3 (a kind gift from K. Shirahige38, 1:1,500), WAPL (Santa Cruz, no. sc365189, 1:1,000), SMC1 (Bethyl, no. A300-055A, 1:2,000), SMC3 (Bethyl, no. A300-060A-5, 1:2,000), SCC1 (Millipore,

(8) A Mediator-cohesin axis controls heterochromatin domain formationNature communicationsFebruary 8, 2022Haarhuis JHI, van der Weide RH, Blomen VA, Flach KD, Teunissen H, Willems L, Brummelkamp TR, Rowland BD, de Wit E.written macro (ImageJ). Western blot The following antibodies were used for western blots: WAPL (A-7, sc-365189, Santa Cruz), HSP90 (F-8, sc-13119, Santa Cruz), MED12 (A300-774A, Bethyl), CCNC (ab85927, Abcam), CTCF

(9) Hi-C analyses with GENOVA: a case study with cohesin variantsNAR genomics and bioinformaticsJune 1, 2021van der Weide RH, van den Brand T, Haarhuis JHI, Teunissen H, Rowland BD, de Wit E.analysis. Used antibodies for the western blots were ab4457 (SA1) from Abcam, 158a (SA2) from Bethyl, sc365189 (WAPL) and sc13119 (HSP90) from Santa Cruz. Rad21 immunofluorescence was performed with Millipore 05-908

(10) Lysosomal degradation ensures accurate chromosomal segregation to prevent chromosomal instabilityAutophagyMarch 1, 2021Almacellas E, Pelletier J, Day C, Ambrosio S, Tauler A, Mauvezin C.,Santa Cruz Biotechnology,sc-13125 WAPL,WB 1/1000 IF 1/50,Bethyl Lab. Santa Cruz Biotechnology,A300-268A-M sc-365189 Secondary antibodies,,, Antigen,Dilution,Source,Catalog Number Anti-mouse Ig HRP,WB 1/5000,Dako,P0260 Anti-rabbit

(11) Loop extrusion as a mechanism for formation of DNA damage repair fociNatureFebruary 1, 2021Arnould C, Rocher V, Finoux AL, Clouaire T, Li K, Zhou F, Caron P, Mangeot PE, Ricci EP, Mourad R, et al.ab11171,3 μg SCC1,ChIP,Abeam ab992,4 μg SCC1,Western Blot,Abeam ab992,1:500 WAPL,Western Blot,Santa Cruz sc-365189,1:500 NIPBL,Western Blot,Bethyl Laboratories A301-779A,1:1000 MRE11,Western Blot,GeneTex GTX70212

(12) Cohesin promotes stochastic domain intermingling to ensure proper regulation of boundary-proximal genesNature geneticsAugust 1, 2020Luppino JM, Park DS, Nguyen SC, Lan Y, Xu Z, Yunker R, Joyce EF.antibodies: RAD21 (Abcam ab992, 1:500 or 1:1000), NIPBL (Santa Cruz sc-374625, 1:400), WAPL (Santa Cruz sc-365189, 1:250), alpha tubulin (Sigma T6074, 1:1,000), Histone H3 (Abcam ab1791, 1:40,000), and CTCF (Santa Cruz

(13) Replication stress induces mitotic death through parallel pathways regulated by WAPL and telomere deprotectionNature communicationsSeptember 17, 2019Masamsetti VP, Low RRJ, Mak KS, O'Connor A, Riffkin CD, Lamm N, Crabbe L, Karlseder J, Huang DCS, Hayashi MT, et al.Millipore), TRF1 (1:500, sc-56807, Santa Cruz), TRF2 (1:1000, NB110-57130, Novus Biologicals), WAPL (1:1000, SC-365189, Santa Cruz), β-actin (1:10,000, A5441, Sigma), BAX (1:1000, rat monoclonal 49F9; WEHI monoclonal antibody

(14) Systematic proteomics of endogenous human cohesin reveals an interaction with diverse splicing factors and RNA-binding proteins required for mitotic progressionThe Journal of biological chemistryMay 31, 2019Kim JS, He X, Liu J, Duan Z, Kim T, Gerard J, Kim B, Pillai MM, Lane WS, Noble WS, et al.

(15) Perturbing cohesin dynamics drives MRE11 nuclease-dependent replication fork slowingNucleic acids researchFebruary 20, 2019Carvajal-Maldonado D, Byrum AK, Jackson J, Wessel S, Lemaçon D, Guitton-Sert L, Quinet A, Tirman S, Graziano S, Masson JY, et al.

(16) Architectural Proteins and Pluripotency Factors Cooperate to Orchestrate the Transcriptional Response of hESCs to Temperature StressMolecular cellSeptember 20, 2018Lyu X, Rowley MJ, Corces VG.

(17) Non-random Mis-segregation of Human ChromosomesCell reportsJune 12, 2018Worrall JT, Tamura N, Mazzagatti A, Shaikh N, van Lingen T, Bakker B, Spierings DCJ, Vladimirou E, Foijer F, McClelland SE.glycerol 10%, and 1× protease inhibitor [Roche]). Immunoblots were probed with antibodies against Wapl (Sc-365189; Santa Cruz) and alpha-tubulin (T0674; Sigma-Aldrich) and developed using goat anti-mouse IgG horseradish

(18) TAT-mediated si-hWAPL inhibits the invasion and metastasis of cervical cancer stem cellsExperimental and therapeutic medicineDecember 1, 2017Gong P, Hu C, Zhou X, Wang R, Duan Z.with anti-HPV E6, Oct4 and hWAPL antibodies (1:100 dilution in PBS, cat. nos. sc-460, sc-101534 and sc-365189, respectively) or GAPDH (1:500 dilution, cat. no. sc-293335) (both from Santa Cruz Biotechnology, Inc.).

(19) Intact Cohesion, Anaphase, and Chromosome Segregation in Human Cells Harboring Tumor-Derived Mutations in STAG2PLoS geneticsFebruary 1, 2016Kim JS, He X, Orr B, Wutz G, Hill V, Peters JM, Compton DA, Waldman T.

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WAPL (A-7) Antibody

WAPL (A-7) Antibody from Santa Cruz Biotechnology, Inc.

Santa Cruz Biotechnology, Inc.

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WAPL (A-7) Antibody from Santa Cruz Biotechnology, Inc.

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