LEF1 (C18A7) Rabbit mAb 2286S from Cell Signaling Technology

Product Specs
ItemLEF1 (C18A7) Rabbit mAb
CompanyCell Signaling Technology
Price $339.00 Inquire
Catalog Number2286S
Quantity100 µl
ApplicationsW, IP
ReactivityH, M, R
TargetLEF1
HostRabbit
NCBI Gene AliasesLEF-1, TCF10, TCF1ALPHA, TCF7L3
ClonalityMonoclonal
NCBI Full Gene Namelymphoid enhancer binding factor 1
Research AreaDevelopmental Biology
CloneC18A7
Molecular Weight25-58 kDa

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Cell Signaling Technology

3 Trask Lane

Danvers, Massachusetts 01923

United States

Phone: 877-616-CELL
Phone: 978-867-2388
Fax: 866-432-6112
Fax: 978-867-2488

Company Profile

Website: http://www.cellsignal.com/

Website: Technical Support

(1) HMGB1 couples LEF1 to regulate B cell immunityJCI InsightSeptember 23, 2025Qiuyue Chen, Ziyin Zhang, Nanshu Xiang, Li Luo, Xin Dai, Danqing Kang, Lu Yang, Yingzi Zhu, Jiang Chang, Yukai Jing, et al.(9167S; CST), anti-STAT1 (14994; CST), anti-pSTAT5 (4322S; CST), anti-STAT5 (ab194898; Abcam), anti-LEF1 (2286S; CST), anti-c-Myc (13987S; CST), anti-HMGB1 (ab190377; Abcam), pJNK1/2 (AP0473; Abclonal), LC3 (A5618;

(2) The Effects and Mechanisms of Patchouli Alcohol on Experimental Periodontitis Rats Based on the OPG/RANK/RANKL/P38 MAPK Signaling PathwayJ Inflamm ResSeptember 13, 2025Shuting Zhang, Feifei Duan, Tianzhen He, Chaoqun Sun, Menglu Zhen, Enxi Liang, Xingduo Liu, Yuqiong Dai, Ruoting Zhan, Nianchun Hu, et al.primary antibodies: anti-OPG (R1608-4, HUABIO, 1:1000), anti-RANK (ER1915-70, HUABIO, 1:2000), p38 MAPK (2286T, CST, 1:1000), phospho-p38 MAPK (4511T, CST, 1:1000), RANKL (23408-1-AP, Proteintech, 1:1000), β-actin

(3) The Effects and Mechanisms of Patchouli Alcohol on Experimental Periodontitis Rats Based on the OPG/RANK/RANKL/P38 MAPK Signaling PathwayJournal of Inflammation ResearchSeptember 13, 2025Shuting Zhang, Feifei Duan, Tianzhen He, Chaoqun Sun, Menglu Zhen, Enxi Liang, Xingduo Liu, Yuqiong Dai, Ruoting Zhan, Nianchun Hu, et al.primary antibodies: anti-OPG (R1608-4, HUABIO, 1:1000), anti-RANK (ER1915-70, HUABIO, 1:2000), p38 MAPK (2286T, CST, 1:1000), phospho-p38 MAPK (4511T, CST, 1:1000), RANKL (23408-1-AP, Proteintech, 1:1000), β-actin

(4) Particulate matter and co-occurring genetic risk induce oxidative stress and cardiac and brain Alzheimer's pathologyCommun BiolApril 12, 2025Helen M. Butler, Everette Keller, Marice McCrorey, Gizem Keceli, Colin K. Combs, Rakez Kayed, Rajasekaran Namakkal-S, Nazareno Paolocci, Bethany Jacobs Wolf, Loren E. Wold, et al.structural antibody (1:1000)83 (generous gift of Dr. Kayed UTMB), OC (1:1000) (Millipore Sigma Catalog#2286). Secondary antibody incubation utilized anti-rabbit IgG HRP Linked (1:1000) (Cell Signaling; Catalog#7074).

(5) Phosphorylation and ubiquitination of OsWRKY31 are integral to OsMKK10-2-mediated defense responses in riceThe Plant CellMay 29, 2023Shuai Wang, Shuying Han, Xiangui Zhou, Changjiang Zhao, Lina Guo, Junqi Zhang, Fei Liu, Qixin Huo, Wensheng Zhao, Zejian Guo, et al.plants, anti-pTEpY (Cell Signaling Technology, 9101S, 1:2,000 dilution) and anti-W31pS6 (ChinaPeptides, 2286-R4, 1:10,000) were used in immunoblotting. Electrophoretic mobility shift assay The W-box containing

(6) Suppression of preadipocyte determination by SOX4 limits white adipocyte hyperplasia in obesityiScienceApril 21, 2023He T, Wang S, Li S, Shen H, Hou L, Liu Y, Wei Y, Xie F, Zhang Z, Zhao Z, et al.polyclonal anti-Phospho-β-catenin,CST,Cat#9561; RRID: AB_331729 Mouse monoclonal anti-Lef1,CST,Cat#2286; RRID: AB_659971 Mouse polyclonal anti-Lef1,Proteintech,Cat#14972-1-AP; RRID:AB_2265677 Rabbit polyclonal

(7) Gut microbiota transplantation drives the adoptive transfer of colonic genotype-phenotype characteristics between mice lacking catestatin and their wild type counterpartsGut MicrobesDecember 31, 2022Pamela GonzÃ¡lez-DÃ¡vila, Markus Schwalbe, Arpit Danewalia, RenÃ© Wardenaar, Boushra Dalile, Kristin Verbeke, Sushil K Mahata, Sahar El Aidytissue compared to the CST-KO mice, with 1987 (log2FC >2: 629) of these genes being upregulated and 2286 (log2FC >2: 916) downregulated (Figure 3A). Principal component analysis (PCA) performed on normalized

(8) Segmental basaloid follicular hamartomas derive from a post‐zygotic SMO p.L412F pathogenic variant and express hair follicle development‐related proteins in a pattern that distinguish them from basal cell carcinomasAmerican Journal of Medical Genetics Part ADecember 1, 2022Lihi Atzmony, Nelson Ugwu, Lionel G. Bercovitch, Leslie Robinson‐Bostom, Christine J. Ko, Peggy Myung, Keith A. Choatewere incubated overnight at 4°C with the following antibodies: rabbit anti-Lef1 (1:100, Cell signaling 2286S), mouse anti-β-catenin (1:100, BD Sciences, 610153), rabbit anti-SOX9 (1:500, Millipore, ab5535) and

(9) Decomposing a deterministic path to mesenchymal niche formation by two intersecting morphogen gradientsDevelopmental cellApril 25, 2022Qu R, Gupta K, Dong D, Jiang Y, Landa B, Saez C, Strickland G, Levinsohn J, Weng PL, Taketo MM, et al.incubated overnight at 4 °C with the following antibodies: rabbit anti-Sox2 (1:400, Cell signaling 2286S), goat anti-Pcadherin (1:500, R&D Systems, AF761), mouse anti-caspase3 (1:100, BD Sciences, 610153).

(10) Intrinsic and acquired drug resistance to LSD1 inhibitors in small cell lung cancer occurs through a TEAD4-driven transcriptional stateMolecular oncologyMarch 1, 2022Yan W, Chung CY, Xie T, Ozeck M, Nichols TC, Frey J, Udyavar AR, Sharma S, Paul TA.(CST 3576), CHGA (Abcam, Branford, CT, USA, 45179), FOXA2 (CST 3143), OVOL2 (Abcam 129161), LEF1 (CST 2286), ASCL1 (Abnova, Walnut, CA, USA, H0429‐M02), SOX2 (CST 4900), INSM1 (Abcam 170876), NEUROD1 (117562),

(11) Urethral configuration and mobility during urine leaking described using real-time transperineal ultrasonographyUltrasonographyJanuary 1, 2022Baihua Zhao, Lieming Wen, Dan Liu, Shanya HuangStress urinary incontinence: relative importance of urethral support and urethral closure pressure. J Urol 2008;179:2286-2290. 7. Wen L, Zhao B, Chen W, Qing Z, Liu M. Real-time assessment of the behaviour of the bladder

(12) The importation and establishment of community transmission of SARS-CoV-2 during the first eight weeks of the South African COVID-19 epidemicEClinicalMedicineSeptember 1, 2021Kerrigan M. McCarthy, Stefano Tempia, Tendesayi Kufa, Jackie Kleynhans, Nicole Wolter, Waasila Jassat, Joy Ebonwu, Anne von Gottberg, Linda Erasmus, Mazvita Muchengeti, et al.patients with available information, the commonest reported symptoms were fever/rigors/chills (1523/2286; 66.6%), cough (1868/2995; 62.4%) and sore throat (1197/2274; 53%). Co-morbidities were present in 1047/3043

(13) Wnt-Dependent Activation of ERK Mediates Repression of Chondrocyte Fate during Calvarial DevelopmentJournal of Developmental BiologyJune 27, 2021Beatriz A Ibarra, Cody Machen, Radhika P. AtitCell Signaling Technology 9102, Danvers, MA, USA), and rabbit-anti-Lef1 (1:500, Cell Signaling Technology 2286, Danvers, MA, USA). Species-specific HRP-conjugated secondary antibodies were used at 1:10,000. Immunoblots

(14) Roles of Melatonin in Goat Hair Follicle Stem Cell Proliferation and Pluripotency Through Regulating the Wnt Signaling PathwayFrontiers in Cell and Developmental BiologyJune 4, 2021Weidong Zhang, Niu Wang, Tongtong Zhang, Meng Wang, Wei Ge, Xin WangBiotech D220068 Lymphoid enhancer binding factor 1 Anti-LEF1 rabbit polyclonal antibody Cell signaling 2286 Myelocytomatosis oncogene Tag Anti-c-Myc Tag rabbit polyclonal antibody Sangon Biotech D110006 NogginOrganic

(15) β-elemene enhances the antitumor activity of erlotinib by inducing apoptosis through AMPK and MAPK pathways in TKI-resistant H1975 lung cancer cellsJournal of CancerFebruary 22, 2021Jue Wang et al.β-elemene on EGFR L858R/ T790M double mutation NCI-H1975 cells and the potential molecular mechanisms. 2286 t-Erk, GAPDH, t-AKT, Bax, CHOP, and PARP were purchased from Cell Signaling Technology (Danvers, MA,

(16) The prognostic significance of GRB7 protein expression and localization in human breast and ovarian cancersOncotargetJune 16, 2020Anke Vermehren-Schmaedick, Paulette Mhawech-Fauceglia, Byung S. Park, Tanja Pejovic, Shiuh-Wen LuohWestern blots Antibodies anti-human GRB7, rabbit monoclonal antibody (Abcam, Cat# 183737 [EPR14099]); anti α-tubulin, mouse 2286 Oncotarget monoclonal antibody (Cell signaling, Danvers, MA, USA, Cat# 3873s); anti HER-2/ErbB2

(17) Modeling stratospheric intrusion and trans-Pacific transport on tropospheric ozone using hemispheric CMAQ during April 2010 â€“ Part 2: Examination of emission impacts based on the higher-order decoupled direct methodAtmospheric Chemistry and PhysicsMarch 23, 2020Syuichi Itahashi, Rohit Mathur, Christian Hogrefe, Sergey L. Napelenok, Yang ZhangTime (EST) Elevated CASTNET sites N Emission impacts from the US Emission impacts from east Asia 2286 238 359 489 1200 587 0.63∗∗∗ 0.52∗∗∗ 0.65∗∗∗ 0.55∗∗∗ 0.64∗∗∗ 0.52∗∗∗ −0.03 0.38∗∗∗ 0.36∗∗∗ 0.06 −0.02 0.22∗∗∗ Note:

(18) Identifying the Cellular Interactome of Epstein-Barr Virus Lytic Regulator Zta Reveals Cellular Targets Contributing to Viral ReplicationJournal of virologyJanuary 17, 2020Zhou Y, Heesom K, Osborn K, AlMohammed R, Sweet SM, Sinclair AJ.cross-linking of the antibody to the beads. For LEF1 immunoprecipitations, rabbit LEF1 antibody (catalog number 2286s) from CST was used, and for EBF1, mouse EBF antibody (C-8) (catalog number sc-137065; Santa Cruz) was used.

(19) Dose-Dependent and Subset-Specific Regulation of Midbrain Dopaminergic Neuron Differentiation by LEF1-Mediated WNT1/b-Catenin SignalingFrontiers in cell and developmental biologyJanuary 1, 2020Nouri P, Götz S, Rauser B, Irmler M, Peng C, Trümbach D, Kempny C, Lechermeier CG, Bryniok A, Dlugos A, et al.et al. (2011). Blots were probed with two different rabbit anti-LEF1 mAbs [C12A5 (#2230) and C18A7 (#2286); 1:1000, Cell Signaling Technology], mouse anti-b-actin (ACTB) mAb (1:5000; abcam ab6276) and HRP-conjugated

(20) Single-cell Transcriptome Profiling reveals Dermal and Epithelial cell fate decisions during Embryonic Hair Follicle DevelopmentTheranosticsJanuary 1, 2020Ge W, Tan SJ, Wang SH, Li L, Sun XF, Shen W, Wang X.Rabbit monoclonal anti-LEF1,Cell Signaling,"Cat# 2286, RRID:AB_659971" Rabbit polyclonal anti-CTNNB1,Proteintech,"Cat# 51067-2-AP, RRID:AB_2086128" Rabbit

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LEF1 (C18A7) Rabbit mAb

LEF1 (C18A7) Rabbit mAb from Cell Signaling Technology

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Cell Signaling Technology

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LEF1 (C18A7) Rabbit mAb from Cell Signaling Technology

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