Complement Component C3d Antibody AF2655 from R&D Systems, a Bio-Techne Brand

Product Specs
ItemComplement Component C3d Antibody
CompanyR&D Systems, a Bio-Techne Brand
Price Pricing Info Supplier Page View Company Product Page
Catalog NumberAF2655
ApplicationsWestern Blot, Immunohistochemistry
TargetComplement Component C3d
ReactivityMouse, Rat
Conjugate/TagUnconjugated
IsotypeIgG
Quantity100 ug (also 25 ug)
HostGoat
ClonalityPolyclonal
FormatLyophilized from a 0.2 µm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS
ImmunogenE. coli-derived recombinant mouse Complement Component C3d, His1002-Arg1303 (Cys1010Ser), Accession # P01027
NCBI Full Gene Namecomplement component 3, complement C3
NCBI Gene AliasesCPAMD1, HEL-S-62p, ASP, ARMD9, Plp, HSE-MSF, C3a, C3b, AHUS5
ConcentrationLYOPH
PurityAntigen Affinity-purified
Brand/TrademarkR&D Systems, a Bio-Techne Brand
Antibody TypePrimary Antibodies
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution

Specifications/Features

Available conjugates: Unconjugated

Specificity: Detects mouse Complement Component C3d in direct ELISAs and Western blots. Detects mouse and rat Complement Component C3d in immunohistochemistry

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R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) High-intensity interval training ameliorates Alzheimer's disease-like pathology by regulating astrocyte phenotype-associated AQP4 polarizationTheranosticsJanuary 1, 2023Feng S, Wu C, Zou P, Deng Q, Chen Z, Li M, Zhu L, Li F, Liu TC, Duan R, et al.

(2) Mechanistic target of rapamycin complex 1 orchestrates the interplay between hepatocytes and Kupffer cells to determine the outcome of immune-mediated hepatitisCell death & diseaseDecember 9, 2022Sun X, Ni Y, Lu Q, Liang Y, Gu M, Xue X, Dai C.Cell Signaling Technology, USA), CFB (cat: NBP1-89985, Novus; cat: ab192577, Abcam, Cambridge, UK), C3d (cat: AF2655, R&D Systems) or TdT-mediated dUTP-biotin nick end labeling (TUNEL, Promega, Madison, WI). Images were

(3) The engineered AAV2-HBKO promotes non-invasive gene delivery to large brain regions beyond ultrasound targeted sitesMolecular therapy. Methods & clinical developmentDecember 8, 2022Kofoed RH, Noseworthy K, Wu K, Sivadas S, Stanek L, Elmer B, Hynynen K, Shihabuddin LS, Aubert I.MAB 5406), rabbit anti-IBA1 1:500 (Wako, 016–20001), and rat anti-MHC class II 1:200 (R&D Systems, AF2655). All secondary antibodies were purchased from Jackson ImmunoResearch and diluted 1:400. Histology

(4) Impact of Aβ40 and Aβ42 Fibrils on the Transcriptome of Primary Astrocytes and MicrogliaBiomedicinesNovember 19, 2022Zhu X, Schrader JM, Irizarry BA, Smith SO, Van Nostrand WE.astrocyte markers, transgenic AD rat brain sections were incubated with rabbit antibody to C3 (1:200, AF2655, Novus, Centennial, CO, USA), and rabbit antibody to GBP2 (1:200, ab203238, Abcam, Boston, MA, USA).

(5) SIRT1 inactivation switches reactive astrocytes to an antiinflammatory phenotype in CNS autoimmunityThe Journal of clinical investigationNovember 15, 2022Zhang W, Xiao D, Li X, Zhang Y, Rasouli J, Casella G, Boehm A, Hwang D, Ishikawa LL, Thome R, et al.clone 11-5B, Abcam); mouse anti-mAPC (OP80, clone CC1, EMD Millipore); goat anti-C3d (mouse and human) (AF2655, R&D Systems); rabbit anti-S100A10 (mouse and human) (MA5-15326, 4E7E10, Abcam); rabbit anti-SRXN1 (MBS716745,

(6) Blocking C3d(+)/GFAP(+) A1 Astrocyte Conversion with Semaglutide Attenuates Blood-Brain Barrier Disruption in Mice after Ischemic StrokeAging and diseaseJune 1, 2022Zhang Q, Liu C, Shi R, Zhou S, Shan H, Deng L, Chen T, Guo Y, Zhang Z, Yang GY, et al.10% BSA for 1 hour at room temperature. Astrocytes were incubated with antibodies against C3d (1:100, AF2655, R&D system, Minneapolis, MN), S100A10 (1:100, AF2377, R&D system), and glial ﬁbrillary acidic protein

(7) Microglia Depletion from Primary Glial Cultures Enables to Accurately Address the Immune Response of AstrocytesBiomoleculesMay 4, 2022Van Zeller M, Sebastião AM, Valente CA.(anti-Iba-1, 1:500, Abcam, ab5076), goat-raised anti-Complement 3 antibody (anti-C3, 1:500, R&D Systems, AF2655) and mouse-raised anti-Pentraxin-3 antibody (anti-PTX3, 1:500, Santa Cruz, SC-373,951). Membranes were

(8) Astrocytic phagocytosis contributes to demyelination after focal cortical ischemia in miceNature communicationsMarch 3, 2022Wan T, Zhu W, Zhao Y, Zhang X, Ye R, Zuo M, Xu P, Huang Z, Zhang C, Xie Y, et al.(OP80), dMBP (AB5864) and Olig2 (AB9610) were purchased from Millipore, USA; antibodies against C3d (AF2655), Galectin3 (AF1197), LAMP1 (AF4320) and LCN2 (AF1857) were purchased from R&D Systems, USA; antibodies

(9) C-Reactive Protein Protects Against Acetaminophen-Induced Liver Injury by Preventing Complement OveractivationCellular and molecular gastroenterology and hepatologyJanuary 1, 2022Li HY, Tang ZM, Wang Z, Lv JM, Liu XL, Liang YL, Cheng B, Gao N, Ji SR, Wu Y.HM1605; lot number: 24277M0518-A; 1:500), or anti-C3d (R&D Systems, Minneapolis, MN; catalog number: AF2655; lot number: VFL0518101; 0.5 μg/mL) antibodies. The deposition of these complement components was then

(10) Transgene distribution and immune response after ultrasound delivery of rAAV9 and PHP.B to the brain in a mouse model of amyloidosisMolecular therapy. Methods & clinical developmentDecember 10, 2021Kofoed RH, Heinen S, Silburt J, Dubey S, Dibia CL, Maes M, Simpson EM, Hynynen K, Aubert I.NB100-53809), rabbit anti-S100B 1:800 (Abcam; ab41548), goat anti-complement component C3d 1:200 (R&D Systems; AF2655), tomato lectin 1:200 (Vector Laboratories; B-1175), rabbit anti-CD3 1:200 (Abcam; ab16669), and rat

(11) C4d Deposition after Allogeneic Renal Transplantation in Rats Is Involved in Initial Apoptotic Cell ClearanceCellsDecember 10, 2021Reuter S, Kentrup D, Grabner A, Köhler G, Buscher K, Edemir B.Hycult Biotech (HP8034; Uden, The Netherlands). C3d deposition was analysed using an anti-C3d antibody (AF2655, R&D Systems, Abingdon, UK). Deposited IgM was detected using an FITC-labelled anti-IgM antibody (#

(12) Role of uromodulin and complement activation in the progression of kidney diseaseOncology lettersDecember 1, 2021Shen F, Liu M, Pei F, Yu L, Yang X.

(13) A potent truncated form of human soluble CR1 is protective in a mouse model of renal ischemia-reperfusion injuryScientific reportsNovember 8, 2021Bongoni AK, Vikstrom IB, McRae JL, Salvaris EJ, Fisicaro N, Pearse MJ, Wymann S, Rowe T, Morelli AB, Hardy MP, et al.

(14) Complement factor B in high glucose-induced podocyte injury and diabetic kidney diseaseJCI insightOctober 8, 2021Lu Q, Hou Q, Cao K, Sun X, Liang Y, Gu M, Xue X, Zhao AZ, Dai C.Cell Signaling Technology), anti-Rheb1 (catalog ab25873, Abcam), anti-CFB (catalog ab192577, Abcam), anti-C3d (catalog AF2655, R&D Systems, Bio-Techne), anti-C5b-9 (catalog ab55811, Abcam), anti-C5aR (catalog BS1522, Bioworld),

(15) BAD-mediated neuronal apoptosis and neuroinflammation contribute to Alzheimer's disease pathologyiScienceSeptember 24, 2021Zhang L, Qian Y, Li J, Zhou X, Xu H, Yan J, Xiang J, Yuan X, Sun B, Sisodia SS, et al.anti-β-actin,Santa Cruz Biotechnology,Cat# sc-47778; RRID:AB_2714189 Goat anti-C3d,R&D Systems,Cat# AF2655; RRID:AB_2066622 Sheep anti-TREM2,R&D Systems,Cat# AF1729; RRID:AB_354956 Mouse anti-Caspase-1 p20

(16) TNFRSF13B genotypes control immune-mediated pathology by regulating the functions of innate B cellsJCI insightSeptember 8, 2021de Mattos Barbosa MG, Lefferts AR, Huynh D, Liu H, Zhang Y, Fu B, Barnes J, Samaniego M, Bram RJ, Geha RS, et al.heart sections were incubated with the primary antibodies goat anti–mouse C3d (800 ng/mL, R&D Systems AF2655, RRID:AB_2066622), goat anti–mouse IgM, human adsorbed (10 μg/mL; Southern Biotech 1020-01, RRID:AB_2794197),

(17) The thrombin receptor modulates astroglia-neuron trophic coupling and neural repair after spinal cord injuryGliaSeptember 1, 2021Kim HN, Triplet EM, Radulovic M, Bouchal S, Kleppe LS, Simon WL, Yoon H, Scarisbrick IA.(SC-271430),AB_10648473,1:200 Beta III Tubulin,Chicken,Millipore (AB9354),AB_570918,1:500 C3D,Goat,R&D Systems (AF2655),AB_2066622,1:500 CD163,Mouse,Abcam (ab111250),AB_10888308,1:100 CD68,Rabbit,Abcam (ab125212),AB_10975465,1:1000 DAPI,N/A,ThermoFisher Scientific

(18) Sodium Iodate-Induced Degeneration Results in Local Complement Changes and Inflammatory Processes in Murine RetinaInternational journal of molecular sciencesAugust 26, 2021Enzbrenner A, Zulliger R, Biber J, Pousa AMQ, Schäfer N, Stucki C, Giroud N, Berrera M, Kortvely E, Schmucki R, et al.(BSA) and 0.1% Tween 20 in Tris-buffered saline) and primary antibodies (goat anti-C3d antibody (Cat. #AF2655; R&D Systems) or rabbit anti-GAPDH antibody (Cat. #CSB-PA00025A0Rb; Cusabio Technology LLC, Houston,

(19) Inducing regulated necrosis and shifting macrophage polarization with anti-EMMPRIN antibody (161-pAb) and complement factorsJournal of leukocyte biologyAugust 1, 2021Hijaze N, Ledersnaider M, Simanovich E, Kassem S, Rahat MA.

(20) The Sez6 Family Inhibits Complement by Facilitating Factor I Cleavage of C3b and Accelerating the Decay of C3 ConvertasesFrontiers in immunologyJanuary 1, 2021Qiu WQ, Luo S, Ma SA, Saminathan P, Li H, Gunnersen JM, Gelbard HA, Hammond JW.Tween 20) for 30 minutes and probed with primary antibodies: polyclonal goat anti-C3d (R&D systems, AF2655, 1:1000), polyclonal sheep anti-Sez6L2 (R&D Systems, AF4916; 1:2000), monoclonal mouse anti-Myc (Developmental

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Complement Component C3d Antibody

Complement Component C3d Antibody

Complement Component C3d Antibody

Complement Component C3d Antibody

Complement Component C3d Antibody

Complement Component C3d Antibody from R&D Systems, a Bio-Techne Brand

Specifications/Features

R&D Systems, a Bio-Techne Brand

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Complement Component C3d Antibody from R&D Systems, a Bio-Techne Brand

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