STEP Antibody (23E5)

Product Specs
ItemSTEP Antibody (23E5) - BSA Free
CompanyNovus Biologicals, a Bio-Techne Brand
Price $429.00Supplier Page View Company Product Page
Catalog NumberNB300-202
ImmunogenA synthetic peptide of rat STEP46 (amino acids 57-74: MCTPGCNEEGFGYLVSPR)
ApplicationsIF/IHC,Immunohistochemistry,Immunoprecipitation,Western Blot,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Immunocytochemistry/ Immunofluorescence
ReactivityHuman,Mouse,Rat
ClonalityMonoclonal
HostMouse
FormatAscites
TargetSTEP
Clone23E5
Quantity0.1 ml (also 0.025 ml)
Conjugate/TagUnconjugated
IsotypeIgG1
Antibody TypePrimary Antibodies
StorageAliquot and store at -20C or -80C. Avoid freeze-thaw cycles
NCBI Full Gene Nameprotein tyrosine phosphatase non-receptor type 5
NCBI Gene AliasesPTPSTEP, STEP, STEP61
Research AreaAlzheimers Research, Cancer, Cellular Markers, Hypoxia, Neurodegeneration, Neuroscience, Protein Phosphatase, Signal Transduction
PurityUnpurified

Specifications/Features

Available conjugates: Available conjugates: Unconjugated

Specificity: NB300-202 is specific for STEP61, STEP46, STEP38, and STEP20.

Sizes Available: 0.1 ml (also 0.025 ml)

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Novus Biologicals, a Bio-Techne Brand

United States: 10771 E Easter Ave

Centennial, Colorado 80112

United States

Phone:
303-730-1950
888-506-6887

Email: novus@novusbio.com

Company Profile

Website: https://www.novusbio.com

(1) Excitotoxic inactivation of constitutive oxidative stress detoxification pathway in neurons can be rescued by PKD1Nature communicationsDecember 22, 2017Pose-Utrilla J, García-Guerra L, Del Puerto A, Martín A, Jurado-Arjona J, De León-Reyes NS, Gamir-Morralla A, Sebastián-Serrano Á, García-Gallo M, Kremer L, et al.

(2) The tyrosine phosphatase STEP mediates AMPA receptor endocytosis after metabotropic glutamate receptor stimulationThe Journal of neuroscience : the official journal of the Society for NeuroscienceOctober 15, 2008Zhang Y, Venkitaramani DV, Gladding CM, Zhang Y, Kurup P, Molnar E, Collingridge GL, Lombroso PJ.

(3) Calcium-dependent cleavage of striatal enriched tyrosine phosphatase (STEP)Journal of neurochemistryJanuary 1, 0001"Nguyen TH, Paul S, Xu Y, Gurd JW, Lombroso PJ."

(4) Synaptic plasticity (and the lack thereof) in hippocampal CA2 neuronsThe Journal of neuroscience : the official journal of the Society for NeuroscienceJanuary 1, 0001"Zhao M, Choi YS, Obrietan K, Dudek SM."

(5) Hypoxia-ischemia in perinatal rat brain induces the formation of a low molecular weight isoform of striatal enriched tyrosine phosphatase (STEP)Journal of neurochemistryJanuary 1, 0001"Gurd JW, Bissoon N, Nguyen TH, Lombroso PJ, Rider CC, Beesley PW, Vannucci SJ."

(6) Selective reduction of APP-BACE1 activity improves memory via NMDA-NR2B receptor-mediated mechanisms in aged PDAPP miceNeurobiology of agingJanuary 1, 0001"Evans CE, Thomas RS, Freeman TJ, Hvoslef-Eide M, Good MA, Kidd EJ."

(7) Striatal enriched phosphatase 61 dephosphorylates Fyn at phosphotyrosine 420The Journal of biological chemistryJanuary 1, 0001"Nguyen TH, Liu J, Lombroso PJ."

(8) Cellular and molecular characterization of a brain-enriched protein tyrosine phosphataseThe Journal of neuroscience : the official journal of the Society for NeuroscienceJanuary 1, 0001"Boulanger LM, Lombroso PJ, Raghunathan A, During MJ, Wahle P, Naegele JR."

(9) A single fraction from Uncaria sinensis exerts neuroprotective effects against glutamate-induced neurotoxicity in primary cultured cortical neuronsAnatomy & cell biologyJanuary 1, 0001"Kim HN, Jang JY, Choi BT."

(10) Ginsenoside Rg1 alleviates repeated alcohol exposure-induced psychomotor and cognitive deficitsChinese medicineJanuary 1, 0001"Huang L, Peng Z, Lu C, Chen Y, Lv JW, Qin M, Liao DF, Liu XM, Shi Z."

(11) Chronic Stress Induces Maladaptive Behaviors by Activating Corticotropin-Releasing Hormone Signaling in the Mouse Oval Bed Nucleus of the Stria TerminalisThe Journal of neuroscience : the official journal of the Society for NeuroscienceJanuary 1, 0001"Hu P, Liu J, Maita I, Kwok C, Gu E, Gergues MM, Kelada F, Phan M, Zhou JN, Swaab DF, et al."

(12) NMDA-mediated activation of the tyrosine phosphatase STEP regulates the duration of ERK signalingNature neuroscienceJanuary 1, 0001"Paul S, Nairn AC, Wang P, Lombroso PJ."

(13) Dephosphorylation of specific sites in the kinase-specificity sequence domain leads to ubiquitin-mediated degradation of the tyrosine phosphatase STEPThe Biochemical journalJanuary 1, 0001"Mukherjee S, Poddar R, Deb I, Paul S."

(14) NR2B-NMDA receptor mediated modulation of the tyrosine phosphatase STEP regulates glutamate induced neuronal cell deathJournal of neurochemistryJanuary 1, 0001"Poddar R, Deb I, Mukherjee S, Paul S."

(15) Regulator of calmodulin signaling knockout mice display anxiety-like behavior and motivational deficitsThe European journal of neuroscienceJanuary 1, 0001"Davis MM, Olausson P, Greengard P, Taylor JR, Nairn AC."

(16) A role for calmodulin-stimulated adenylyl cyclases in cocaine sensitizationThe Journal of neuroscience : the official journal of the Society for NeuroscienceJanuary 1, 0001"DiRocco DP, Scheiner ZS, Sindreu CB, Chan GC, Storm DR."

(17) Short and long access to cocaine self-administration activates tyrosine phosphatase STEP and attenuates GluN expression but differentially regulates GluA expression in the prefrontal cortexPsychopharmacologyJanuary 1, 0001"Sun WL, Zelek-Molik A, McGinty JF."

(18) "Neuroprotective role of a brain-enriched tyrosine phosphatase, STEP, in focal cerebral ischemia"The Journal of neuroscience : the official journal of the Society for NeuroscienceJanuary 1, 0001"Deb I, Manhas N, Poddar R, Rajagopal S, Allan AM, Lombroso PJ, Rosenberg GA, Candelario-Jalil E, Paul S."

(19) Phospho-regulation of synaptic and extrasynaptic N-methyl-d-aspartate receptors in adult hippocampal slicesNeuroscienceJanuary 1, 0001"Goebel-Goody SM, Davies KD, Alvestad Linger RM, Freund RK, Browning MD."

(20) STEP61: a member of a family of brain-enriched PTPs is localized to the endoplasmic reticulumThe Journal of neuroscience : the official journal of the Society for NeuroscienceJanuary 1, 0001"Bult A, Zhao F, Dirkx R Jr, Sharma E, Lukacsi E, Solimena M, Naegele JR, Lombroso PJ."

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STEP Antibody (23E5)

STEP Antibody (23E5)

STEP Antibody (23E5)

STEP Antibody (23E5) - BSA Free from Novus Biologicals, a Bio-Techne Brand

Specifications/Features

Novus Biologicals, a Bio-Techne Brand

Citations (42)

Reviews

STEP Antibody (23E5) - BSA Free from Novus Biologicals, a Bio-Techne Brand

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