RhoA (67B9) Rabbit mAb 2117S from Cell Signaling Technology

Product Specs
ItemRhoA (67B9) Rabbit mAb
CompanyCell Signaling Technology
Price $339.00 Inquire
Catalog Number2117S
Quantity100 µl
ApplicationsW, W-S, IHC-P, IF-IC
ReactivityH, M, R, Mk, B
TargetRhoA
IsotypeIgG
HostRabbit
NCBI Gene AliasesARH12, ARHA, EDFAOB, RHO12, RHOH12
NCBI Full Gene Nameras homolog family member A
Clone67B9
Molecular Weight21
ClonalityMonoclonal
Research AreaCytoskeletal Signaling

Questions and Answers

Can this antibody be used to study RhoA signaling in cancer cells?

Yes, the RhoA (67B9) Rabbit mAb has been utilized in various studies to investigate RhoA signaling pathways in cancer cells. For instance, it was employed in the analysis of the RhoA/ROCK signaling pathway's involvement in hypersensitivity reactions induced by paclitaxel injection, highlighting its role in vascular hyperpermeability and inflammation ().

Is this antibody effective for Western blot applications?

The RhoA (67B9) Rabbit mAb has been shown to work effectively in Western blot applications, as evidenced by its use in multiple studies, including those examining the mutational landscape of cutaneous T cell lymphoma and Sézary syndrome, where it was used to detect total RhoA protein levels ().

What species can this antibody be used with?

This antibody is reactive with several species, including human, mouse, rat, bovine, and non-human primates, making it versatile for various experimental models in cell biology research.

Are there any specific applications where this antibody has been cited?

The RhoA (67B9) Rabbit mAb has been cited in studies focusing on endothelial cell integrity and inflammation, as well as in investigations of RhoA's role in cancer cell invasion and metastasis, indicating its relevance in both basic and applied research contexts (, ).

Cell Signaling Technology

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Phone: 978-867-2388
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Company Profile

Website: http://www.cellsignal.com/

Website: Technical Support

(1) E- and N-cadherin drive hepatic polarity and lumen elongation via opposing effects on RhoA activityJ Cell BiolAugust 3, 2026Junya Hayase, Li Yang, Yu-Heng Zhou, Kangji Wang, Cheng-Ran Xu, Erfei Biand anti-N-cadherin (D4R1H, 13116), anti-catenin δ-1/p120-catenin (D7S2M, 59854), anti-RhoA (67B9, 2117), anti-RhoB (D1J9V, 63876), anti-RhoC (D40E4, 3430), anti-ROCK1 (E2G4N, 28999), anti-ROCK2 (E5T5P, 47012),

(2) Rnd3 regulates lung cancer cell invasion and migration independently of ROCK1 signaling via alpha 5 integrin modulationLife Science AllianceMay 1, 2026Noemi Garcia Garcia, Thanh Ha Vy Nguyen, Dane Richey, Emily F Cox, Jon Coca Juaristi, Cody Ashby, Analiz Rodriguez, Katie R Ryan(Invitrogen). Primary antibodies used in this study were as follows: Rnd3 (3664), ROCK1 (4035), RhoA (2117) pMLC2 (3671), pCofilin (3313), Cofilin (5175), alpha 5 (4705), alpha V (4711), beta 1 (9699), beta

(3) RhoB supports rubella infection and impairs endothelial barrier integrity through downstream ROCK signalingCell Commun SignalApril 27, 2026Igor Kovacevic, Marie Müller, Leonie Mair, Vivien Henschke, Annkatrin Kowalski, Jes-Niels Boeckel, Karolin Kropf, Guido Posern, Uta Reibetanz, Claudia ClausSanta Cruz Biotechnology), rabbit anti-GAPDH D16H11 XP (#5174S, Cell Signaling Technology), anti-RhoA (67B9) rabbit mAb, (#2117, Cell Signaling Technology) and anti-RhoB (D1J9V) rabbit mAb (#63876, Cell Signaling Technology) were

(4) Gastrodin alleviates neuronal damage in epileptic cell models by targeting P2RY12 to inhibit microglial hyperactivationPLoS OneApril 17, 2026Aiyuan Cai, Zilong Li, Ran Liu, Hailong Huang, Ping Liu, Ruizhong Zhang, Jing Xiao, Yuanhong Lin, Qingpeng Hu, Haixia Wuthen added: P2RY12 antibody (dilution ratio 1:1000), RhoA antibody (Cell Signaling Technology, USA, 2117, dilution ratio 1:1000), ROCK antibody (Cell Signaling Technology, USA, 4035, dilution ratio 1:1000),

(5) Proteomic Profiling Reveals How Physiological Media Reshape Cancer Cell Proteomes and Signaling NetworksMolecular & Cellular ProteomicsApril 15, 2026Colin Zenge, Brittany Q. Pham, Ki Hong Nam, Elana Apfelbaum, Heeseon An, Alban Ordureau(Cell Signaling Technology, 9234S), 4EBP1 (Cell Signaling Technology, 9644T), RhoA (Cell Signaling Technology, 2117T), UMPS (ProteinTech Group, 14830-1-AP), UCK2 (ProteinTech Group, 10511-1-AP), DHODH (ProteinTech Group,

(6) Protocol to identify covalent inhibitors targeting RhoA Cys16STAR ProtocApril 14, 2026Tin-Yan Koo, Chloe See-Hang Ho, Hillary Yui-Yan Yip, Clive Yik-Sham ChungRESOURCE,SOURCE,IDENTIFIER Antibodies,Antibodies,Antibodies ,, RhoA (67B9) Rabbit mAb(Dilution 1:1000 for WB),Cell Signaling Technology,Cat# 2117S; RRID:AB_10693922 Anti-GFP (D5.1) XP®(Dilution 1:1000 for WB),Cell Signaling Technology,Cat# 2956S;

(7) Macrophage Migration Inhibitory Factor (MIF)-CD74 Signaling Pathway Mediates Trabecular Meshwork Dysfunction in GlaucomabioRxivMarch 24, 2026Monu Monu, Lal Krishan Kumar, Prince Kumar, Gulab Zode, Pawan Kumar SinghNFκB (#6956), pSTAT3 (#9145), STAT3 (#9139), RIP3K (#10188), pMLKL (#18640), MLKL (#14993), RhoA (#2117), ROCK1 (#4035), pMLC (#3674), MLC (#3672), MIF (#75038), CD74 (#77274), Blimp-1 (#9115) (Cell Signaling Technology

(8) MRCKα Is a Suppressor of GEF-H1/RhoA/MRTF Signaling in Tubular CellsCellsMarch 2, 2026Veroni S. Sri Theivakadadcham, Qinghong Dan, Brian Wu, Shruthi Venugopal, Vida Maksimoska, Aysegul Yucel-Polat, Andras Kapus, Katalin SzásziIrvine, CA, USA). The following antibodies were obtained from Cell Signaling Technology: RhoA (Cat# 2117S, RRID: AB_10693922), Phospho-Myosin Light Chain 2 (Thr18/Ser19) (E2J8F0) (Cat# 95777, RRID:AB_3677547),

(9) Magnesium ions facilitate osteogenic differentiation and intervertebral fusion via m6A methylation of RhoA mRNAJournal of Orthopaedic TranslationMarch 1, 2026Haocheng Xu, Linli Li, Fan Zhang, Minghao Shao, Chenyan Li, Yitong Xue, Dachuan Li, Zhidi Lin, Zhaoyang Gong, Jiongdong Wu, et al.were incubated overnight at 4 °C with primary antibodies: anti-RhoA (1:200; Cell Signaling Technology, 2117S), anti-METTL3 (1:200; Cell Signaling Technology, 86132S), and anti-Runx2 (1:200; Cell Signaling Technology,

(10) PRRSV-2 impedes lysosomes from eliminating secondary infected bacteriaPLOS PathogensFebruary 27, 2026Zifang Zheng, Xue Ling, Shuang Qiao, Jie Wu, Shuangquan Zhang, Xiao Liu, Yang Li, Caiyun Xie, Zhiqian Ma, Xuyang Guo, et al.Agricultural Sciences, Lanzhou, China). Antibodies and chemicals Anti-RhoA monoclonal antibody (#2117) was purchased from Cell Signaling Technology, Anti-Smurf1 (sc-100616) was purchased from Santa Cruz Biotechnology

(11) Chemomechanical remodeling of glucocorticoid-sensitive fibroblasts for multimodal synergistic therapy of skin fibrosisCell Reports MedicineFebruary 17, 2026Yifei Lu, Peng Yang, Weiming Gou, Yangping Wang, Li Ran, Lin Shi, Yiming Qin, Jingyuan Li, Ning Zhang, Dongdong Xue, et al.AB_2924220 anti-HDAC2,Abcam,Cat# ab32117; RRID: AB_732777 anti-RhoA,Cell Signaling Technology,Cat# 2117; RRID: AB_10693922 anti-Vinculin,Cell Signaling Technology,Cat# 13901; RRID: AB_2728768 anti-COL1A1,Cell Signaling Technology

(12) Cell jamming transition is regulated by mitochondrial pyruvate transport and endocytosisbioRxivFebruary 13, 2026Alexandra Bermudez, Zoe Latham, Johnny Diaz, Weihong Yan, Jerry Chen, Dapeng Bi, Andrew Goldstein, Jimmy K Hu, Neil Y.C. LinE-cadherin (Abcam, ab11512), YAP (Novus Biologicals, NB110-58358), RhoA (Cell Signaling Technology, 2117T), Rac-1 GTP (NewEast Biosciences, 26903), or EEA1 (BD Biosciences, 610456). After washing three times

(13) Kaempferol Alleviates Glucocorticoid-Induced Osteonecrosis of the Femoral Head by Modulating Macrophage M1/M2 Polarization Through RhoA/ROCK-Mediated Mitophagy ActivationBiomedicinesFebruary 9, 2026Yuankai Zhang, Yan Zhao, Shangqing Zhang, Tian Lei, Bocheng Xiang, Xin Zhang, Kai Nan, Lihong Fan(Abcam, ab23707), anti-P62 (CST, 5114T), anti-LC3B (Abcam, Waltham, MA, USA, Ab192890), anti-RhoA (CST, 2117T), anti-Parkin (CST, 32833T), and anti-ROCK (Abcam, ab45171). 2.6. RAW264.7 Cells Conditioned Medium

(14) TTBK2‐Driven Ciliogenesis Is Required for Intrinsic Neuronal Regeneration After Spinal Cord InjuryCNS Neuroscience & TherapeuticsJanuary 24, 2026Renfeng Zhang, Su Pan, Zhenwei Tian, Haorui Du, Jintao Wang, Xiaoyu Yang, Zhiping Qi1:200), mouse anti‐GLI‐1/GLI1 (C‐1) (santa sc‐515751, 1:500), RhoA (67B9) rabbit mAb (Cell Signaling, 2117, 1:1000), chicken anti‐MAP2 (MAP2) (Abcam, ab5392, 1:1000), rabbit anti‐PSD95 (Cell Signaling, 3450,

(15) The therapeutic potential and mechanisms of targeting the PTBP1/Nogo-A/NgR axis in PTSD induced by single prolonged stress in miceExperimental & Molecular MedicineJanuary 21, 2026Bing-Yao Liu, Xing-Dong Chen, Hui-Lin Liu, Si-Wei Wang, Qian-Zhong Song, Hui Cheng, Sen Li, Hai-Yan Wang, Xiu-Min Lu, Yong-Tang Wanganti-GAP-43 (1:1,000, CST, 8945S), anti-Nogo-A (1:1,000, Abcam, ab47085), anti-RhoA (1:1,000, CST, 2117S), anti-ROCK2 (1:1,000, CST, 9029S), anti-β-actin (1:7,000, Sigma, A1978) and anti-GAPDH (1:7,000, CST,

(16) Oxypeucedanin attenuates neuropathic pain in male mice via inhibiting lysophosphatidic acid receptor signalingiScienceJanuary 16, 2026Jiejia Li, Wenting Tang, Liyun Wang, Yipeng Gu, Wenhui You, Wenxin Yang, Yanlong Huang, Xinyue Yu, Ruiyang Zhu, Yue Xu, et al.RRID:AB_447619), ROCK1(Cell Signaling Technology Cat# 28999, RRID:AB_3096125), RhoA(Cell Signaling Technology Cat# 2117, RRID:AB_10693922), p-MYPT1(Thr696)(Cell Signaling Technology Cat# 5163, RRID:AB_10691830) and internal

(17) Improved protein binder design using β-pairing targeted RFdiffusionNature CommunicationsJanuary 10, 2026Isaac Sappington, Martin Toul, David S. Lee, Stephanie A. Robinson, Inna Goreshnik, Clara McCurdy, Tung Ching Chan, Nic Buchholz, Buwei Huang, Dionne Vafeados, et al.(Thr202/Tyr204) (Cell Signaling Technology, #9101) 1:10,000 dilution, and either S6 (Cell Signaling Technology, #2117) at 1:1000 dilution or H3 (Cell Signaling Technology, #9715) at 1:5000 dilution as a loading control.

(18) RSPO4 exerts tumor suppression through antagonizing canonical and non-canonical Wnt signalingInternational Journal of Biological SciencesJanuary 1, 2026Zhenfang Du, Lili Li, Xingsheng Shu, Chen Li, Qian Tao(#9251S), Phospho-p44/42 MAPK (Erk1/2) (Thr202/Tyr204) (#9101), p44/42 MAPK (Erk1/2) (#9102), RhoA (67B9) (#2117), Src (#2108), phospho-Src Family (Tyr416) (D49G4) (#6943), phospho-c-Jun (Ser63) II (#9261) and E-cadherin

(19) Context-dependent inhibitory roles of RhoA in 3D invasive cell migration within the extracellular matrixCell ReportsDecember 23, 2025Wakiko Iwata, Yoshihiro Adachi, Junior J. West, Andrew J. Ewald, Yi Zheng, Laura D. Wood, Robert A. Anders, Hiromi Sesaki, Miho Iijima(IPFL00010, Millipore). The membranes were incubated with primary antibodies against RHOA (1:1000 dilution, 2117, Cell Signaling), GAPDH (1:2000 dilution, MA5–15738, Thermo Fisher Scientific), RHOB (1:1000 dilution,

(20) CHI3L1 promotes cell division through activation of RhoA in lung cancer cellsCell Communication and SignalingDecember 17, 2025Ji Eun Yu, Jung-Hyun Shim, In Jun Yeo, Dong Ju Son, Jaesuk Yun, Key-Hwan Lim, Hanseul Park, Yoon Seok Roh, Sang-Bae Han, Jin Tae HongDallas, TX), anti-Aurora B (dilution 1:1000; #ab3609, Abcam, Cambridge, UK), anti-RhoA (dilution 1:1000; #2117, Cell Signaling, Boston, MA), anti-Ect2 (dilution 1:500; #sc-514750, Santa Cruz), anti-α-tubulin (dilution

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RhoA (67B9) Rabbit mAb

RhoA (67B9) Rabbit mAb from Cell Signaling Technology

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Cell Signaling Technology

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RhoA (67B9) Rabbit mAb from Cell Signaling Technology

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