RhoA (67B9) Rabbit mAb 2117S from Cell Signaling Technology

Product Specs
ItemRhoA (67B9) Rabbit mAb
CompanyCell Signaling Technology
Price $339.00 Inquire
Catalog Number2117S
Quantity100 µl
ApplicationsW, W-S, IHC-P, IF-IC
ReactivityH, M, R, Mk, B
TargetRhoA
IsotypeIgG
HostRabbit
NCBI Gene AliasesARH12, ARHA, EDFAOB, RHO12, RHOH12
NCBI Full Gene Nameras homolog family member A
Clone67B9
Molecular Weight21
ClonalityMonoclonal
Research AreaCytoskeletal Signaling

Questions and Answers

Can this antibody be used to study RhoA signaling in cancer cells?

Yes, the RhoA (67B9) Rabbit mAb has been utilized in various studies to investigate RhoA signaling pathways in cancer cells. For instance, it was employed in the analysis of the RhoA/ROCK signaling pathway's involvement in hypersensitivity reactions induced by paclitaxel injection, highlighting its role in vascular hyperpermeability and inflammation ().

Is this antibody effective for Western blot applications?

The RhoA (67B9) Rabbit mAb has been shown to work effectively in Western blot applications, as evidenced by its use in multiple studies, including those examining the mutational landscape of cutaneous T cell lymphoma and Sézary syndrome, where it was used to detect total RhoA protein levels ().

What species can this antibody be used with?

This antibody is reactive with several species, including human, mouse, rat, bovine, and non-human primates, making it versatile for various experimental models in cell biology research.

Are there any specific applications where this antibody has been cited?

The RhoA (67B9) Rabbit mAb has been cited in studies focusing on endothelial cell integrity and inflammation, as well as in investigations of RhoA's role in cancer cell invasion and metastasis, indicating its relevance in both basic and applied research contexts (, ).

Cell Signaling Technology

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Phone: 978-867-2388
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Company Profile

Website: http://www.cellsignal.com/

Website: Technical Support

(21) RHOA regulates mitochondria-ER contact sites through modulation of the VAPB/PTPIP51 tetherNat CommunDecember 14, 2025Zheng Yang, Shintaro Nakajima, Hsiuchen Chen, Yogaditya Chakrabarty, Huibao Feng, David C. ChanVPS13D (Proteintech, 29387-1-AP) (WB: 1:500), DRP1 (ABCAM, ab184247) (WB: 1:1000), RHOA (Cell Signaling, 2117S) (WB: 1:500), CUL3 (Proteintech, 11107-1-AP) (WB: 1:2000), BACURD3 (Proteintech, 27279-1-AP) (WB: 1:1000),

(22) Laetiporus sulphureus Mycelial Extract Promotes Melanogenesis via p38 MAPK-Mediated Activation of β-Catenin/MITF and Rho Family Proteins in B16F10 CellsJ Microbiol BiotechnolDecember 9, 2025So Jung Park, Hyeok Jin Choi, Jeong Won Choi, Gyeong Eun Im, Youngki Park, Kyoung Tae Lee, Jin Boo JeongC3 botulinum toxin substrate 1 (Rac 1, cat. no. 4651), Ras homolog family member A (RhoA, cat. no. 2117), and β-actin (5125) (all from Cell Signaling Technology, USA); tyrosinase (cat. no. sc-20035) from

(23) α-Parvin regulation of cell re-arrangement is critical for ureteric bud branching morphogenesisbioRxivDecember 8, 2025Xinyu Dong, Fabian Bock, Ali Hashmi, Nada Bulus, Glenda Mernaugh, Gema Bolas, Shensen Li, Wanying Zhu, Meiling Melzer, Kyle Brown, et al.,Cell Signaling,4970 Mouse monoclonal anti-β-Actin,Cell Signaling,3700 Rabbit monoclonal anti-RhoA,Cell Signaling,2117 Rabbit polyclonal anti-Cdc42,Cell Signaling,2462 Rabbit monoclonal anti-phospho-cofilin,Cell Signaling,3313 Rabbit

(24) The mechanisms by which RhoA activity and associated synaptic effects are controlled by the DISC1 scaffolding-like proteinBiological PsychiatryDecember 6, 2025Kathryn J. Bjornson, Michael E. Cahill,Santa Cruz Biotechnology,"Cat# sc-166740, RRID:AB_2059900", Antibody,Anti-RhoA antibody,Cell Signaling Technology,"Cat# 2117, RRID:AB_10693922", Antibody,Anti-AF6/afadin antibody,Cell Signaling Technology,"Cat# 13531, RRID:AB_2798249", Antibody,Anti-GFP

(25) Systematic Evaluation of GAPs and GEFs Identifies a Targetable Dependency for Hematopoietic MalignanciesCancer DiscoveryDecember 2, 2025Pu Zhang, Zhendong Cao, Xiangyu Pan, Yuqiao Liu, Cynthia Castro, Won Jun Kim, Takeshi Fujino, Jennifer Lewis, Jahan Rahman, Sanam Shahid, et al.,Cell Signaling Technology,"Cat# 4877, RRID:AB_2233307" Rhoa (67B9) Rabbit mAb,Cell Signaling Technology,"Cat# 2117, RRID:AB_10693922" APC-CD3,BD Biosciences,CAT#340440: RRID:AB_400513 BV605-CD8,Biolegend,CAT#344741;

(26) Systematic evaluation of GAPs and GEFs identifies a targetable dependency for hematopoietic malignanciesCancer DiscovDecember 2, 2025Pu Zhang, Zhendong Cao, Xiangyu Pan, Yuqiao Liu, Cynthia Castro, Won Jun Kim, Takeshi Fujino, Jennifer Lewis, Jahan Rahman, Sanam Shahid, et al.,Cell Signaling Technology,"Cat# 4877, RRID:AB_2233307" Rhoa (67B9) Rabbit mAb,Cell Signaling Technology,"Cat# 2117, RRID:AB_10693922" APC-CD3,BD Biosciences,CAT#340440: RRID:AB_400513 BV605-CD8,Biolegend,CAT#344741;

(27) KSR1 is a scaffold for the Hippo signaling pathwayCommun BiolDecember 1, 2025Samar Sayedyahossein, Mohammed Rizwan Babu Sait, Zhigang Li, Riddhi Banerjee, Andy Tran, Louise Thines, Mehdi Karimi, Mehrnoosh Bahmani, Naomi Mishan, Pooya Borzou, et al.#1",WB:1/1000 phosphoPaxillinY118,"Cell Signaling Technology, #69363, E9U9F, #1",IF: 1/100 RhoA,"Cell Signaling Technology, #2117, 67B9, #6",WB:1/1000 panTEAD,"Cell Signaling Technology, #13295, D3F7L, #1",WB:1/1000 β-tubulin,"Millipore,

(28) Galectin-9 regulates dendritic cell polarity and uropod contraction by modulating RhoA activityJournal of Cell BiologyNovember 3, 2025Guus A. Franken, Harry Warner, Jorge Cuenca-Escalona, Isabel F. Stehle, Vince P.A. van Reijmersdal, Sophie E. Klomp, Koert Schreurs, Andrea Rodgers-Furones, Rohit Rajesh Gokhale, Manon Vullings, et al.human serum supplemented with primary antibodies against RhoA (1:300, #sc-418; Santa Cruz and 1:200, #2117S; Cell Signaling), GEF-H1 (1:600, #GTX125893; GeneTex), and CD44 (1:500, #8E2F3; Novus Biologicals) for

(29) Targeting TRPV4 to restore glymphatic system function and alleviate cerebral edema in ischemic strokeBrain PathologyNovember 1, 2025Yongchuan Li, Haiping Zhou, Jiaxin Xie, Mingjia Yu, Guanyu Ye, Yuzhen Zhang, Zhentong Li, Kunxue Zhang, Jingwen Wu, Sheng Xiao, et al.anti‐MMP9 (1:3000, Proteintech, Cat # 10375‐2‐AP), and anti‐RhoA (1:1000, Cell Signaling Technology, Cat # 2117 T). After incubating the membrane with anti‐rabbit horseradish peroxidase‐conjugated secondary antibodies

(30) SIRT7 drives energy metabolic shifts in endometriosis via interaction with TUFM and Rhoa/Rock/Akt pathway activationCell Mol Life SciOctober 30, 2025Huaying Zhang, Jiahao Chen, Mengjie Yang, Xinyu Ding, Guolin Chai, Ruofan Huang, Dianchao Lin, Zhixiong Huang, Qionghua Chen(Cell Signaling Technology, Cat# 13116, RRID: AB_2687616), and anti-RhoA (Cell Signaling Technology, Cat# 2117, RRID: AB_10693922) antibodies. For immunoprecipitation experiments, approximately 10% of the cellular

(31) Integrin α8‐Mediated Pericyte Morphogenesis Controls Blood‐Brain Barrier IntegrityAdvanced ScienceOctober 14, 2025Chang‐Xiong Gong, Lin‐Lin Hu, Ling Jiang, Pei‐Xia Shi, Shuang Zhang, Yuan Zhao, Bing‐Qiao Wang, Xiao‐Feng Cheng, Cheng‐Kang He, Sen Lin, et al.(CST),8505,1:1000 Phospho‐Myosin Light Chain 2 (Thr18/Ser19) antibody (E2J8F),CST,95777,1:1000 RhoA (67B9) antibody,CST,2117,1:1000 SMAD2/3 antibody,CST,3102,1:1000 "p‐SMAD2/SMAD3 (Ser465, Ser467, Ser423, Ser425) polyclonal

(32) G Protein-Coupled Estrogen Receptor Regulates Mesenchymal Stem Cell Mechanotransduction and DifferentiationCellular and Molecular BioengineeringOctober 11, 2025Hao Wang, Ofra Ben Ben Menachem-Zidon, Ashish Pandey, Yue Xiao, Nanzhong Deng, Xiaojie Shi, Amparo Ruiz, Yi Ye, Haogang Caiantibodies against Phospho-RHOA (Ser188) (Invitrogen, PA5-105763, 1:1000), RhoA (Cell Signaling Technology, 2117, 1:1000), and GAPDH (Cell Signaling Technology, 97166, 1:1000). After washes with TBST, membranes were

(33) Skeletal muscle Rac1 mediates exercise training adaptations towards muscle glycogen resynthesis and protein synthesis☆Redox BiologyOctober 1, 2025Steffen H. Raun, Carlos Henriquez-Olguín, Emma Frank, Farina Schlabs, Nanna Just Hahn, Jonas Roland Knudsen, Mona S. Ali, Nicoline R. Andersen, Lisbeth L.V. Møller, Jonathan Davey, et al.BSA RhoGDIa,Cell Signaling Technology,#2564,1:1000 in 2 % skim milk RhoA,Cell Signaling Technology,#2117,1:1000 in 2 % skim milk CDC42,Cell Signaling Technology,#2462,1:1000 in 3 % BSA p-P38 MAPK T180/Y182,Cell Signaling Technology

(34) Pyrin inflammasome-driven erosive arthritis caused by unprenylated RHO GTPase signalingEMBO molecular medicineOctober 1, 2025Akula MK, Gilis E, Hertens P, Vande Walle L, Sze M, Coudenys J, Incik Y, Khan O, Bergo MO, Elewaut D, et al.1/1000); anti-RAC1 (05-389, Millipore, 1/1000); anti-CDC42 (2462S, Cell Signaling, 1/1000); anti-RHOA (2117S, Cell Signaling, 1/1000); anti-NLRP3 (AG-20B-0014-C100, Adipogen, 1/1000); and anti-Actin (sc-47778,

(35) Local Growth Hormone Facilitates Aging of the Colon Epithelial MicroenvironmentAging cellOctober 1, 2025Chesnokova V, Zonis S, Ainsworth R, Apaydin T, Valencia CW, Greiner EC, Barrett R, Kettenbach AN, Melmed S.(active) β‐catenin (S45), E‐cadherin, cMyc, and RhoA from Cell Signaling (cat#190807, #3195, #5605, and #2117, respectively); Twist2 from Santa Cruz Biotechnology (cat#sc‐81417) or from Lifespan Biosciences (cat#LS‐C416907);

(36) ARHGAP10 is a novel microtubule-associated protein that regulates the resorption activity of osteoclastsJournal of Biological ChemistryOctober 1, 2025Laura Jentschel, Anne Blangy, Guillaume Bompardα-tubulin (YOL1/34, sc-5330, 1:2000), Cell Signaling Technology Myc-Tag (71D10, 2278, 1:2000), RhoA (67B9, 2117, 1:1000), BD Biosciences His (F24–796, 552565, 1:10,000) and Abnova Cdc42 (M152, MAB1376, 1:500). Secondary

(37) Cellular responses to short-term intraocular pressure elevation in a porcine eye explant modelExperimental Eye ResearchOctober 1, 2025Kelsey Ritter-Gordy, Sarah Quillen, Mary E. Pease, Thomas V. Johnson, Bryce Chiang, Harry A. Quigley, Elizabeth C. Kimball7",Rb,Western,1:1000 p-Smad2/3,Abcam,"Ab254407, LOT # 10015952–2",Rb,Western,1:1000 RhoA,Cell Signaling,"2117, LOT # 6",Rb,Western,1:1000 RhoA,Proteintech,"10749–1-AP, LOT # 00130140",Rb,IHC,1:500 ROCK 1,Invitrogen,"PA5–22262,

(38) Mechano-crosstalk between living and artificial cellsNature communicationsSeptember 29, 2025Yu X, Mukwaya V, Wang L, Zhao W, Mann S, Dou H.Ezrin/Radixin/Moesin Rabbit pAb (ABclonal, A21093, 1:250 dilution); RhoA (67B9) Rabbit mAb (Cell Signaling, 2117S, 1:500); Anti-rabbit IgG (H + L), F(ab’) 2 Fragment (Alexa Fluor ® 647 Conjugate, Cell Signaling, 4414S,

(39) Lipoprotein(a)/CD36 Interaction Drives IL-6/RhoA-GTP Signaling and miRNA Epigenetic Regulation in Coronary Artery SpasmPharmaceuticals (Basel)September 16, 2025Yen-Kuang Lin, Tsung-Han Hsieh, Chi-Tai Yeh, Vijesh Kumar Yadav, Iat-Hang Fong, Kuang-Tai Kuo, Nicholas G. Kounis, Patrick Hu, Ming-Yow Hung#ab134120, Lot #CD801209), GAPDH (Abcam, Cat #ab9484, Lot #GAP2203), RhoA (Cell Signaling Technology, Cat #2117), RhoA-GTP (Cat #8820), ROCK1 (Cat #4035), ROCK2 (Cat #9029), t-MBS (Cat #2634), and p-MBS (Cat #3040).

(40) Butyric acid and valeric acid attenuate stress-induced ferroptosis and depressive-like behaviors by suppressing hippocampal neuroinflammationJournal of Translational MedicineSeptember 2, 2025Xiaoying Ma, Weibo Shi, Zhen Wang, Shujin Li, Rufei Ma, Weihao Zhu, Lin Wu, Xiaowei Feng, Bin Cong, Yingmin Lireceptor 41 (GPR41, 1:1000, Huabio, Hangzhou, China), Ras homologue family member A (RhoA, 1:1000, 2117S, CST, MA, US), Rho-associated coiled-coil containing protein kinase 1 (Rock1, 1:1000, ET1609-53, Huabio,

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RhoA (67B9) Rabbit mAb

RhoA (67B9) Rabbit mAb from Cell Signaling Technology

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Cell Signaling Technology

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RhoA (67B9) Rabbit mAb from Cell Signaling Technology

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